A weak adaptive response to alkylation damage in Salmonella typhimurium

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Experiments in molecular genetics

1972 • 28,260 citations

Methods for detecting carcinogens and mutagens with the salmonella/mammalian-microsome mutagenicity test

1975 • 7,413 citations

REGULATION AND EXPRESSION OF THE ADAPTIVE RESPONSE TO ALKYLATING AGENTS

1988 • 645 citations

Nonenzymatic methylation of DNA by the intracellular methyl group donor S-adenosyl-L-methionine is a potentially mutagenic reaction.

1982 • 398 citations

Salmonella typhimurium LT2 strains which are r- m+ for all three chromosomally located systems of DNA restriction and modification

1983 • 294 citations

Adaptive response to alkylating agents involves alteration in situ of O6-methylguanine residues in DNA

1979 • 260 citations

The intracellular signal for induction of resistance to alkylating agents in E. coli

1986 • 222 citations

Suicide inactivation of the E. coli O6-methylguanine-DNA methyltransferase.

1982 • 178 citations

Characterisation and nucleotide sequence ofogt, the O⁶-alkyiguanine-DNA-alkyltransferase gene ofE.coli

1987 • 163 citations

Induction of resistance to alkylating agents in E. coli: the ada+ gene product serves both as a regulatory protein and as an enzyme for repair of mutagenic damage.

1984 • 162 citations

Nonenzymatic methylation of DNA by S-adenosylmethionine in vitro

1982 • 161 citations

Isolation and characterization of Escherichia coli K-12 mutants unable to induce the adaptive response to simple alkylating agents

1979 • 160 citations

Saccharomyces cerevisiae 3-methyladenine DNA glycosylase has homology to the AlkA glycosylase of E. coli and is induced in response to DNA alkylation damage.

1990 • 144 citations

Methyl phosphotriesters in alkylated DNA are repaired by the Ada regulatory protein ofE. coli

1985 • 139 citations

Molecular cloning of a gene which regulates the adaptive response to alkylating agents in Escherichia coli

1983 • 110 citations

Functional domains and methyl acceptor sites of the Escherichia coli ada protein.

1988 • 107 citations

Construction of an Escherichia coli K-12 ada deletion by gene replacement in a recD strain reveals a second methyltransferase that repairs alkylated DNA

1988 • 89 citations

Differences in mutagenic and recombinational DNA repair in enterobacteria.

1985 • 86 citations

Characterization of the major DNA repair methyltransferase activity in unadapted Escherichia coli and identification of a similar activity in Salmonella typhimurium

1989 • 60 citations

Functional sites of the Ada regulatory protein of Escherichia coli

1988 • 59 citations

Resistance to alkylation damage in Escherichia coli: Role of the Ada protein in induction of the adaptive response

1990 • 51 citations

Bacillus subtilis adaoperon encodes two DNA alkyltransferases

1990 • 51 citations

Cloning and characterization of the Salmonella typhimurium ada gene, which encodes O6-methylguanine-DNA methyltransferase

1991 • 48 citations

Expression of theogtgene in wild-type andadamutants ofE.coli

1989 • 44 citations

Response of S. cerevisiae to N-methyl-N′-nitro-N-nitrosoguanidine: mutagenesis, survival and DDR gene expression

1985 • 43 citations

Environmental mutagens that induce the adaptive response to alkylating agents in Escherichia coli

1991 • 43 citations

Resistance of Salmonella typhimurium TA 1535 to O⁶-guanine methylation and mutagenesis induced by low doses of N-methyl-N'-nitro-N-nitrosoguanidine: an apparent constitutive repair activity

1982 • 34 citations

The E. coli ogt gene

1990 • 29 citations

Comutagenic effects exerted by N-nitroso compounds

1979 • 25 citations

Adaptive response orMicrococcus luteusto alkylating chemlcals

1984 • 23 citations

Alkylation mutagenesis in Saccharomyces cerevisiae: lack of evidence for an adaptive response

1986 • 22 citations

Polyclonal antibodies against O6-methylguanine-DNA methyltransferase in adapted bacteria

1988 • 19 citations

Further studies on the induction of mutation in Haemophilus influenzae by N-methyl-N′-nitro-N-nitrosoguanidine: Lack of an inducible error-free repair system and the effect of exposure medium

1980 • 17 citations

An adaptive response to alkylating agents in Aspergillus nidulans

1988 • 11 citations

The Adaptive Response to Alkylation Damage

1989 • 9 citations

Methyl transferases induced during chemical adaptation ofM. luteus

1987 • 5 citations

Nitrosoguanidine-induced adaptive repair in Pseudomonas aeruginosa

1990 • 2 citations