Widespread adaptive response against environmental methylating agents in microorganisms

Biomass Burning in the Tropics: Impact on Atmospheric Chemistry and Biogeochemical Cycles

1990 • 2,558 citations

Carcinogens are Mutagens: A Simple Test System Combining Liver Homogenates for Activation and Bacteria for Detection

1973 • 2,275 citations

The Phylogeny of Prokaryotes

1980 • 1,457 citations

Transcriptional Regulator of Oxidative Stress-Inducible Genes: Direct Activation by Oxidation

1990 • 869 citations

Mammalian O6-alkylguanine-DNA alkyltransferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents.

1990 • 736 citations

REGULATION AND EXPRESSION OF THE ADAPTIVE RESPONSE TO ALKYLATING AGENTS

1988 • 645 citations

INDUCIBLE DNA REPAIR SYSTEMS

1985 • 586 citations

Improved detection of helix-turn-helix DNA-binding motifs in protein sequences

1990 • 526 citations

Nonenzymatic methylation of DNA by the intracellular methyl group donor S-adenosyl-L-methionine is a potentially mutagenic reaction.

1982 • 398 citations

soxR, a locus governing a superoxide response regulon in Escherichia coli K-12

1990 • 341 citations

Methyl Chloride Transferase: a Carbocation Route for Biosynthesis of Halometabolites

1990 • 263 citations

Mammalian synthesis of nitrite, nitrate, nitric oxide, and N-nitrosating agents

1988 • 243 citations

Inducible repair of O-alkylated DNA pyrimidines in Escherichia coli.

1984 • 223 citations

The intracellular signal for induction of resistance to alkylating agents in E. coli

1986 • 222 citations

Structure of streptozotocin

1967 • 221 citations

Active site and complete sequence of the suicidal methyltransferase that counters alkylation mutagenesis.

1985 • 221 citations

GENERAL MICROBIOLOGY OF recA: Environmental and Evolutionary Significance

1990 • 190 citations

Repair of alkylated DNA in Escherichia coli. Physical properties of O6-methylguanine-DNA methyltransferase.

1982 • 172 citations

Induction of resistance to alkylating agents in E. coli: the ada+ gene product serves both as a regulatory protein and as an enzyme for repair of mutagenic damage.

1984 • 162 citations

Nonenzymatic methylation of DNA by S-adenosylmethionine in vitro

1982 • 161 citations

Escherichia coli mutants deficient in 3-methyladenine-DNA glycosylase

1980 • 146 citations

Saccharomyces cerevisiae 3-methyladenine DNA glycosylase has homology to the AlkA glycosylase of E. coli and is induced in response to DNA alkylation damage.

1990 • 144 citations

Methyl phosphotriesters in alkylated DNA are repaired by the Ada regulatory protein ofE. coli

1985 • 139 citations

Screening of microorganisms for nitrosation catalysis at pH 7 and kinetic studies on nitrosamine formation from secondary amines by E. coli strains

1985 • 123 citations

Nitrosamine Formation by Denitrifying and Non-denitrifying Bacteria: Implication of Nitrite Reductase and Nitrate Reductase in Nitrosation Catalysis

1988 • 113 citations

Adaptive response of escherichia coli to alkylation damage

1988 • 108 citations

Functional domains and methyl acceptor sites of the Escherichia coli ada protein.

1988 • 107 citations

Isolation and structure of a cDNA expressing a mammalian 3-methyladenine-DNA glycosylase.

1990 • 104 citations

Dialkylnitrosamine bioactivation and carcinogenesis

1980 • 99 citations

Bacterially catalysed N-nitrosation reactions and their relative importance in the human stomach

1987 • 97 citations

Chromatographic methods for the study of amines from biological material

1961 • 97 citations

Cloning and expression in Escherichia coli of a gene for an alkylbase DNA glycosylase from Saccharomyces cerevisiae; a homologue to the bacterial alkA gene.

1990 • 84 citations

Carbamyl Phosphate

1963 • 77 citations

A common mechanism for repair of O6-methylguanine and O6-ethylguanine in DNA

1982 • 76 citations

Identification and preliminary characterization of an O6-methylguanine DNA repair methyltransferase in the yeast Saccharomyces cerevisiae.

1990 • 68 citations

Characterization of the major DNA repair methyltransferase activity in unadapted Escherichia coli and identification of a similar activity in Salmonella typhimurium

1989 • 60 citations

Bacterial catalysis of nitrosation: involvement of the nar operon of Escherichia coli

1988 • 60 citations

Structure and expression of the alkB gene of Escherichia coli related to the repair of alkylated DNA.

1986 • 58 citations

Resistance to alkylation damage in Escherichia coli: Role of the Ada protein in induction of the adaptive response

1990 • 51 citations

Bacillus subtilis adaoperon encodes two DNA alkyltransferases

1990 • 51 citations

Adaptive response of Bacillus subtilis to N-methyl-N'-nitro-N-nitrosoguanidine

1983 • 50 citations

Cloning and characterization of the Salmonella typhimurium ada gene, which encodes O6-methylguanine-DNA methyltransferase

1991 • 48 citations

Formation of 8-methylguanine as a result of DNA alkylation by methyl radicals generated during horseradish peroxidase-catalyzed oxidation of methylhydrazine.

1990 • 46 citations

Positive and negative regulation of transcription by a cleavage product of Ada protein

1990 • 45 citations

Expression of theogtgene in wild-type andadamutants ofE.coli

1989 • 44 citations

Environmental mutagens that induce the adaptive response to alkylating agents in Escherichia coli

1991 • 43 citations

Response of S. cerevisiae to N-methyl-N′-nitro-N-nitrosoguanidine: mutagenesis, survival and DDR gene expression

1985 • 43 citations

Expression of the ada gene of Escherichia coli in response to alkylating agents

1988 • 41 citations

Expression of DNA damage-inducible genes of Escherichia coli upon treatment with methylating, ethylating and propylating agents

1989 • 37 citations

Bacillus subtilisgene coding for constitutiveO⁶-methylguanine-DNA alkyttransferase

1989 • 37 citations

Mutagenesis and repair of DNA damage caused by nitrogen mustard, N,N′-bis(2-chloroethyl)-N-nitrosourea (BCNU), streptozotocin, and mitomycin C in E. coli

1986 • 36 citations

Resistance of Salmonella typhimurium TA 1535 to O⁶-guanine methylation and mutagenesis induced by low doses of N-methyl-N'-nitro-N-nitrosoguanidine: an apparent constitutive repair activity

1982 • 34 citations

Mutagenicity of dimethylnitrosamine and diethylnitrosamine for Saccharomyces in an in vitro hydroxylation system

1971 • 32 citations

Ability of various alkylating agents to induce adaptive and SOS responses: A study with lacZ fusion

1985 • 30 citations

The E. coli ogt gene

1990 • 29 citations

A weak adaptive response to alkylation damage in Salmonella typhimurium

1991 • 29 citations

Assessment of the genotoxic effects of methyl chloride in human lymphoblasts

1985 • 29 citations

DNA alterations induced by the carbon-centered radical derived from the oxidation of 2-phenylethylhydrazine

1989 • 25 citations

Comutagenic effects exerted by N-nitroso compounds

1979 • 25 citations

Activation of Ada protein as a transcriptional regulator by direct alkylation with methylating agents.

1988 • 25 citations

Cloning and expression of the Bacillus subtilis methyltransferase gene in Escherichia coli ada− cells

1989 • 24 citations

Alkylation mutagenesis in Saccharomyces cerevisiae: lack of evidence for an adaptive response

1986 • 22 citations

Polyclonal antibodies against O6-methylguanine-DNA methyltransferase in adapted bacteria

1988 • 19 citations

Active site amino acid sequence of the bovineO⁶-methylguanine-DNA methyltransferase

1990 • 19 citations

Potent induction of the adaptive response by a weak mutagen, methyl iodide, in Escherichia coli☆

1987 • 17 citations

Induction of the alkylation-inducible aidB gene of Escherichia coli by anaerobiosis

1989 • 14 citations

DNA repair mechanisms affecting cytotoxicity by streptozotocin in E. coli

1989 • 14 citations

Adaptive response induction by bacterial catalysis of nitrosation

1990 • 13 citations

Mechanisms and Consequences of DNA Damage Processing

1989 • 13 citations

Two classes of Bacillus subtilis mutants deficient in the adaptive response to simple alkylating agents

1986 • 13 citations

Cloning of Micrococcus luteus 3-methyladenine-DNA glycosylase genes in Escherichia coli

1986 • 11 citations

An adaptive response to alkylating agents in Aspergillus nidulans

1988 • 11 citations

Adaptive responses to genotoxic damage: Bacterial strategies to prevent ‐mutation and cell death

1987 • 10 citations

Gene expression in E. coli after treatment with streptozotocin

1988 • 10 citations

A constitutive O6-methylguanine-DNA methyltransferase of Rhizobium meliloti

1990 • 7 citations

DNA glycosylase enzymes induced during chemical adaptation ofM. luteus

1987 • 6 citations

Formation of methylurea from methylamine and carbamyl phosphate: A possible environmental hazard

1980 • 5 citations

Methyl transferases induced during chemical adaptation ofM. luteus

1987 • 5 citations