The virtuoso of versatility: POU proteins that flex to fit 1 1Edited by P. Wright

Intrinsically unstructured proteins: re-assessing the protein structure-function paradigm

1999 • 2,867 citations

Comparative Genomics of the Eukaryotes

2000 • 1,688 citations

Coupling of Local Folding to Site-Specific Binding of Proteins to DNA

1994 • 1,382 citations

SMART: a web-based tool for the study of genetically mobile domains

2000 • 1,298 citations

Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1

1990 • 1,211 citations

A tissue-specific transcription factor containing a homeodomain specifies a pituitary phenotype

1988 • 998 citations

Crystal structure of an engrailed homeodomain-DNA complex at 2.8 Å resolution: A framework for understanding homeodomain-DNA interactions

1990 • 996 citations

Expression of a large family of POU-domain regulatory genes in mammalian brain development

1989 • 828 citations

The pituitary-specific transcription factor GHF-1 is a homeobox-containing protein

1988 • 771 citations

The POU domain: a large conserved region in the mammalian pit-1, oct-1, oct-2, and Caenorhabditis elegans unc-86 gene products.

1988 • 750 citations

A lymphoid-specific protein binding to the octamer motif of immunoglobulin genes

1986 • 740 citations

Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex

1999 • 733 citations

The ubiquitous octamer-binding protein Oct-1 contains a POU domain with a homeo box subdomain.

1988 • 670 citations

Correct transcription of an immunoglobulin κ gene requires an upstream fragment containing conserved sequence elements

1984 • 669 citations

Architecture of RNA Polymerase II and Implications for the Transcription Mechanism

2000 • 615 citations

The unc-86 gene product couples cell lineage and cell identity in C. elegans

1990 • 606 citations

Structure of the 5' ends of immunoglobulin genes: a novel conserved sequence.

1984 • 564 citations

Mutations that lead to reiterations in the cell lineages of C. elegans

1981 • 530 citations

Mechanisms of cooperativity and allosteric regulation in proteins

1990 • 514 citations

[25] Ribbons

1997 • 511 citations

Crystal structure of the Oct-1 POU domain bound to an octamer site: DNA recognition with tethered DNA-binding modules

1994 • 506 citations

The redox/DNA repair protein, Ref-1, is essential for early embryonic development in mice.

1996 • 499 citations

Allosteric effects of DNA on transcriptional regulators

1998 • 488 citations

POU domain family values: flexibility, partnerships, and developmental codes.

1997 • 481 citations

Identification of redox/repair protein Ref-1 as a potent activator of p53.

1997 • 479 citations

Protein-DNA contacts in the structure of a homeodomain-DNA complex determined by nuclear magnetic resonance spectroscopy in solution.

1990 • 460 citations

Composite co-activator ARC mediates chromatin-directed transcriptional activation

1999 • 429 citations

The B-cell-specific Oct-2 protein contains POU box- and homeo box-type domains.

1988 • 429 citations

The POU-specific domain of Pit-1 is essential for sequence-specific, high affinity DNA binding and DNA-dependent Pit-1—Pit-1 interactions

1990 • 403 citations

The POU domain: versatility in transcriptional regulation by a flexible two-in-one DNA-binding domain.

1995 • 391 citations

OBF-1, a novel B cell-specific coactivator that stimulates immunoglobulin promoter activity through association with octamer-binding proteins

1995 • 374 citations

Structural Features of Protein−Nucleic Acid Recognition Sites

1999 • 337 citations

The C. elegans cell lineage and differentiation gene unc-86 encodes a protein with a homeodomain and extended similarity to transcription factors

1988 • 334 citations

The POU domain is a bipartite DNA-binding structure

1988 • 304 citations

A B-cell coactivator of octamer-binding transcription factors

1995 • 301 citations

Interaction of cell-type-specific nuclear proteins with immunoglobulin VH promoter region sequences

1986 • 298 citations

Evidence of DNA: protein interactions that mediate HSV-1 immediate early gene activation by VP16.

1988 • 289 citations

Sp1 binds to promoter sequences and activates herpes simplex virus ‘immediate-early’ gene transcription in vitro

1985 • 289 citations

Signal-specific co-activator domain requirements for Pit-1 activation

1998 • 284 citations

TATA-binding protein-independent initiation: YY1, TFIIB, and RNA polymerase II direct basal transcription on supercoiled template DNA

1994 • 275 citations

Cloning, Functional Characterization, and Mechanism of Action of the B-Cell-Specific Transcriptional Coactivator OCA-B

1995 • 273 citations

A novel B cell-derived coactivator potentiates the activation of immunoglobulin promoters by octamer-binding transcription factors

1992 • 272 citations

The DNA binding specificity of the bipartite POU domain and its subdomains.

1992 • 268 citations

Oct-2, although not required for early B-cell development, is critical for later B-cell maturation and for postnatal survival.

1993 • 265 citations

Crystal Structure of the MATa1/MATα2 Homeodomain Heterodimer Bound to DNA

1995 • 260 citations

Nuclear factor III, a novel sequence-specific DNA-binding protein from HeLa cells stimulating adenovirus DNA replication

1986 • 256 citations

The VP16 accessory protein HCF is a family of polypeptides processed from a large precursor protein

1993 • 241 citations

Targeted deletion of the mouse POU domain gene Brn-3a causes selective loss of neurons in the brainstem and trigeminal ganglion, uncoordinated limb movement, and impaired suckling.

1996 • 237 citations

Mitotic Phosphorylation of the Oct-1 Homeodomain and Regulation of Oct-1 DNA Binding Activity

1991 • 237 citations

Crystal structure of the yeast MATα2/MCM1/DNA ternary complex

1998 • 231 citations

Structure of Pit-1 POU domain bound to DNA as a dimer: unexpected arrangement and flexibility.

1997 • 205 citations

Model of forebrain regionalization based on spatiotemporal patterns of POU‐III homeobox gene expression, birthdates, and morphological features

1995 • 202 citations

Cocrystal structure of YY1 bound to the adeno-associated virus P5 initiator

1996 • 187 citations

Oct-1 and Oct-2 potentiate functional interactions of a transcription factor with the proximal sequence element of small nuclear RNA genes.

1992 • 179 citations

Sequence-specific interactions between cellular DNA-binding proteins and the adenovirus origin of DNA replication.

1987 • 169 citations

Spacing and orientation of bipartite DNA-binding motifs as potential functional determinants for POU domain factors.

1993 • 164 citations

Targeting TBP to a non-TATA box cis-regulatory element: a TBP-containing complex activates transcription from snRNA promoters through the PSE.

1993 • 160 citations

Secondary structure determination for the Antennapedia homeodomain by nuclear magnetic resonance and evidence for a helix-turn-helix motif.

1988 • 151 citations

Solution structure of the POU-specific DNA-binding domain of Oct-1

1993 • 144 citations

The B cell coactivator Bob1 shows DNA sequence-dependent complex formation with Oct-1/Oct-2 factors, leading to differential promoter activation.

1996 • 138 citations

Oct-1 POU domain-DNA interactions: cooperative binding of isolated subdomains and effects of covalent linkage.

1996 • 136 citations

The solution structure of the Oct-1 POU-specific domain reveals a striking similarity to the bacteriophage λ repressor DNA-binding domain

1993 • 133 citations

Activation of octamer-containing promoters by either octamer-binding transcription factor 1 (OTF-1) or OTF-2 and requirement of an additional B-cell-specific component for optimal transcription of immunoglobulin promoters.

1990 • 117 citations

The Cellular C1 Factor of the Herpes Simplex Virus Enhancer Complex Is a Family of Polypeptides

1995 • 109 citations

Recruitment of Octamer Transcription Factors to DNA by Glucocorticoid Receptor

1998 • 101 citations

Pit-1 binding to specific DNA sites as a monomer or dimer determines gene-specific use of a tyrosine-dependent synergy domain.

1995 • 101 citations

Linker length and composition influence the flexibility of Oct-1 DNA binding

1997 • 97 citations

The HCF repeat is an unusual proteolytic cleavage signal.

1995 • 94 citations

The novel coactivator C1 (HCF) coordinates multiprotein enhancer formation and mediates transcription activation by GABP

2000 • 91 citations

The Large Subunit of Basal Transcription Factor SNAP_c Is a Myb Domain Protein That Interacts with Oct-1

1998 • 90 citations

Sequence-specific DNA binding of the B-cell-specific coactivator OCA-B.

1996 • 89 citations

Regulation of JC virus by the POU-domain transcription factor Tst-1: implications for progressive multifocal leukoencephalopathy.

1993 • 89 citations

Crystal structure of an OCA-B peptide bound to an Oct-1 POU domain/octamer DNA complex: specific recognition of a protein-DNA interface

1999 • 88 citations

Differential positive control by Oct-1 and Oct-2: activation of a transcriptionally silent motif through Oct-1 and VP16 corecruitment.

1993 • 88 citations

The POU domains of the Oct1 and Oct2 transcription factors mediate specific interaction with TBP

1994 • 88 citations

A Yeast Type II Topoisomerase Selected for Resistance to Quinolones

1995 • 86 citations

POU Domain Factors of the Brn-3 Class Recognize Functional DNA Elements Which Are Distinctive, Symmetrical, and Highly Conserved in Evolution

1997 • 84 citations

SNAPc: a core promoter factor with a built-in DNA-binding damper that is deactivated by the Oct-1 POU domain

1999 • 72 citations

The Oct-1 POU-Specific Domain Can Stimulate Small Nuclear RNA Gene Transcription by Stabilizing the Basal Transcription Complex SNAP_c

1996 • 70 citations

Coactivator OBF-1 Makes Selective Contacts with Both the POU-Specific Domain and the POU Homeodomain and Acts as a Molecular Clamp on DNA

1998 • 69 citations

Combinatorial codes in signaling and synergy: lessons from pituitary development

1999 • 66 citations

Interaction of Oct-1 with TFIIB

1995 • 64 citations

Oct2 Transactivation from a Remote Enhancer Position Requires a B-Cell-Restricted Activity

1992 • 63 citations

Mechanisms for Flexibility in DNA Sequence Recognition and VP16-Induced Complex Formation by the Oct-1 POU Domain

1995 • 62 citations

The Oct-1 POU domain stimulates adenovirus DNA replication by a direct interaction between the viral precursor terminal protein-DNA polymerase complex and the POU homeodomain.

1994 • 55 citations

The Oct-1 POU domain activates snRNA gene transcription by contacting a region in the SNAP_c largest subunit that bears sequence similarities to the Oct-1 coactivator OBF-1

1998 • 55 citations

Pit-1: Clinical Aspects

1996 • 52 citations

OCA-B Is a Functional Analog of VP16 but Targets a Separate Surface of the Oct-1 POU Domain

1997 • 51 citations

Class III POU Genes of Zebrafish Are Predominantly Expressed in the Central Nervous System

1996 • 51 citations

Highly Cooperative Homodimerization Is a Conserved Property of Neural POU Proteins

1998 • 51 citations

Concerted Activity of Host Cell Factor Subregions in Promoting Stable VP16 Complex Assembly and Preventing Interference by the Acidic Activation Domain

1997 • 47 citations

Gene structure and characterization of the murine homologue of the B cell-specific transcriptional coactivator OBF-1 [published erratum appears in Nucleic Acids Res 1996 Jun 15;24(12):2462]

1996 • 47 citations

The Herpes Simplex Virus VP16-induced Complex: Mechanisms of Combinatorial Transcriptional Regulation

1998 • 46 citations

Histone H2B Gene Transcription during Xenopus Early Development Requires Functional Cooperation between Proteins Bound to the CCAAT and Octamer Motifs

1992 • 46 citations

Oct-1 POU and octamer DNA co-operate to recognise the Bob-1 transcription co-activator via induced folding

1999 • 45 citations

Functional Interaction between Oct-1 and Retinoid X Receptor

1999 • 42 citations

Crossing the Line between RNA Polymerases: Transcription of Human snRNA Genes by RNA Polymerases II and III

1998 • 37 citations

Mechanisms of cooperativity and allosteric regulation in proteins

1990 • 37 citations

Solution structure of the Oct-1 POU homeodomain determined by NMR and restrained molecular dynamics

1995 • 35 citations

The Role of POU Domain Proteins in the Regulation of Mammalian Pituitary and Nervous System Development

1999 • 34 citations

Oct2 transactivation from a remote enhancer position requires a B-cell-restricted activity.

1992 • 32 citations

Both Oct-1 and Oct-2A contain domains which can activate the ubiquitously expressed U2 snRNA genes.

1991 • 31 citations

Characterization of Sequence-Specific DNA Binding by the Transcription Factor Oct-1

2000 • 31 citations

Structural flexibility in transcription complex formation revealed by protein–DNA photocrosslinking

1997 • 30 citations

Histone H2B gene transcription during Xenopus early development requires functional cooperation between proteins bound to the CCAAT and octamer motifs.

1992 • 29 citations

Analysis of homeodomain function by structure-based design of a transcription factor.

1995 • 29 citations

Transcription factors and the control of inner ear development

1997 • 28 citations

A negative electrostatic determinant mediates the association between the Escherichia coli trp repressor and its operator DNA

1994 • 24 citations

Cell fate specification and differentiation in the nervous system ofCaenorhabditis elegans

1996 • 20 citations

Mutation of the Oct-1 POU-specific recognition helix leads to altered DNA binding and influences enhancement of adenovirus DNA replication

1995 • 18 citations

Secondary structure of the oct‐3 POU homeodomain as determined by ¹H‐¹⁵N NMR spectroscopy

1993 • 17 citations

Characterisation of the adenovirus preterminal protein and its interaction with the POU homeodomain of NFIII (Oct-1)

1999 • 16 citations

B-Cell Coactivator OBF-1 Exhibits Unusual Transcriptional Properties and Functions in a DNA-Bound Oct-1-Dependent Fashion

1999 • 10 citations

The POU-domain factor Brn-3.0 recognizes characteristic sites in the herpes simplex virus genome

1997 • 8 citations

OCA-B Is a Functional Analog of VP16 but Targets a Separate Surface of the Oct-1 POU Domain

1998 • 4 citations

Deleted Work

1955 • 0 citations