Crystal structure of the Oct-1 POU domain bound to an octamer site: DNA recognition with tethered DNA-binding modules

Accurate bond and angle parameters for X-ray protein structure refinement

1991 • 2,467 citations

Crystallographic R Factor Refinement by Molecular Dynamics

1987 • 1,982 citations

A graphics model building and refinement system for macromolecules

1978 • 1,858 citations

TRANSCRIPTION FACTORS: Structural Families and Principles of DNA Recognition

1992 • 1,411 citations

Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1

1990 • 1,211 citations

Sequence-specific recognition of double helical nucleic acids by proteins.

1976 • 1,123 citations

Resolution of phase ambiguity in macromolecular crystallography

1985 • 1,040 citations

A tissue-specific transcription factor containing a homeodomain specifies a pituitary phenotype

1988 • 998 citations

Crystal structure of an engrailed homeodomain-DNA complex at 2.8 Å resolution: A framework for understanding homeodomain-DNA interactions

1990 • 996 citations

On the attribution and additivity of binding energies

1981 • 902 citations

The Definition of Generalized Helicoidal Parameters and of Axis Curvature for Irregular Nucleic Acids

1988 • 895 citations

Transcriptional regulation

1991 • 893 citations

An efficient general-purpose least-squares refinement program for macromolecular structures

1987 • 871 citations

Expression of a large family of POU-domain regulatory genes in mammalian brain development

1989 • 828 citations

The pituitary-specific transcription factor GHF-1 is a homeobox-containing protein

1988 • 771 citations

The POU domain: a large conserved region in the mammalian pit-1, oct-1, oct-2, and Caenorhabditis elegans unc-86 gene products.

1988 • 750 citations

Crystal structure of a MATα2 homeodomain-operator complex suggests a general model for homeodomain-DNA interactions

1991 • 538 citations

A single amino acid can determine the DNA binding specificity of homeodomain proteins

1989 • 531 citations

Recognition of a DNA Operator by the Repressor of Phage 434: A View at High Resolution

1988 • 531 citations

Activation of Cell-Specific Expression of Rat Growth Hormone and Prolactin Genes by a Common Transcription Factor

1988 • 525 citations

Structure of the Lambda Complex at 2.5 Å Resolution: Details of the Repressor-Operator Interactions

1988 • 500 citations

DNA specificity of the bicoid activator protein is determined by homeodomain recognition helix residue 9

1989 • 487 citations

The structure of the Antennapedia homeodomain determined by NMR spectroscopy in solution: Comparison with prokaryotic repressors

1989 • 468 citations

POU-domain transcription factors: pou-er-ful developmental regulators.

1991 • 461 citations

Protein-DNA contacts in the structure of a homeodomain-DNA complex determined by nuclear magnetic resonance spectroscopy in solution.

1990 • 460 citations

The Oct-1 homoeodomain directs formation of a multiprotein-DNA complex with the HSV transactivator VP16

1989 • 434 citations

The POU-specific domain of Pit-1 is essential for sequence-specific, high affinity DNA binding and DNA-dependent Pit-1—Pit-1 interactions

1990 • 403 citations

A herpesvirus trans-activating protein interacts with transcription factor OTF-1 and other cellular proteins.

1988 • 381 citations

The C. elegans cell lineage and differentiation gene unc-86 encodes a protein with a homeodomain and extended similarity to transcription factors

1988 • 334 citations

The POU domain is a bipartite DNA-binding structure

1988 • 304 citations

DNA binding specificity of homeodomains

1991 • 300 citations

Refined 1.8 Å crystal structure of the λ repressor-operator complex

1992 • 299 citations

The DNA binding specificity of the bipartite POU domain and its subdomains.

1992 • 268 citations

The octamer-binding proteins form multi-protein--DNA complexes with the HSV alpha TIF regulatory protein.

1989 • 245 citations

Proposed acquisition of an animal protein domain by bacteria.

1992 • 244 citations

The winged-helix DNA-binding motif: Another helix-turn-helix takeoff

1993 • 242 citations

Mitotic Phosphorylation of the Oct-1 Homeodomain and Regulation of Oct-1 DNA Binding Activity

1991 • 237 citations

Regulation of transcription and cell identity by POU domain proteins

1991 • 233 citations

I-POU: a POU-domain protein that inhibits neuron-specific gene activation

1991 • 217 citations

Structure of a phage 434 Cro/DNA complex

1988 • 195 citations

OBP100 binds remarkably degenerate octamer motifs through specific interactions with flanking sequences.

1988 • 184 citations

Spacing and orientation of bipartite DNA-binding motifs as potential functional determinants for POU domain factors.

1993 • 164 citations

Differential Phosphorylation of the Transcription Factor Oct1 During the Cell Cycle

1991 • 145 citations

Solution structure of the POU-specific DNA-binding domain of Oct-1

1993 • 144 citations

Octamer transcription factors bind to two different sequence motifs of the immunoglobulin heavy chain promoter.

1989 • 139 citations

The phage 434 complex at 2.5 Å resolution

1991 • 139 citations

The oct-1 homeo domain contacts only part of the octamer sequence and full oct-1 DNA-binding activity requires the POU-specific domain.

1990 • 135 citations

The solution structure of the Oct-1 POU-specific domain reveals a striking similarity to the bacteriophage λ repressor DNA-binding domain

1993 • 133 citations

Twin of I-POU: A two amino acid difference in the I-POU homeodomain distinguishes an activator from an inhibitor of transcription

1992 • 113 citations

POU proteins bend DNA via the POU-specific domain.

1991 • 111 citations

Conserved Residues Make Similar Contacts in Two Repressor-Operator Complexes

1990 • 101 citations

Segments of the POU domain influence one another's DNA-binding specificity.

1992 • 99 citations

Octamer Transcription Factors 1 and 2 Each Bind to Two Different Functional Elements in the Immunoglobulin Heavy-Chain Promoter

1989 • 90 citations

NMR detection of hydration water in the intermolecular interface of a protein-DNA complex

1993 • 83 citations

Reaction of alkoxysilane coupling agents with dehydroxylated silica surfaces

1993 • 52 citations

Biochemical characterization of the Oct-2 POU domain with implications for bipartite DNA recognition

1992 • 40 citations

Octamer transcription factors 1 and 2 each bind to two different functional elements in the immunoglobulin heavy-chain promoter.

1989 • 38 citations

Improving multiple isomorphous replacement phasing by heavy-atom refinement using solvent-flattened phases

1992 • 25 citations