Rho GTPases and leucocyte-induced endothelial remodelling

Calcium's Role in Mechanotransduction during Muscle Development

2014 • 14,293 citations

Lipid rafts and signal transduction

2000 • 6,079 citations

Cell Migration: Integrating Signals from Front to Back

2003 • 4,755 citations

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase)

1996 • 2,843 citations

Leukocyte-endothelial cell recognition: Three (or more) steps to specificity and diversity

1991 • 2,806 citations

Rho GTPases and their effector proteins

2000 • 1,941 citations

ROCKs: multifunctional kinases in cell behaviour

2003 • 1,866 citations

Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice

1995 • 1,810 citations

Rho and Rac Take Center Stage

2004 • 1,797 citations

Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes

1989 • 1,715 citations

FRET imaging

2003 • 1,690 citations

Rho-stimulated contractility drives the formation of stress fibers and focal adhesions.

1996 • 1,614 citations

ERM proteins and merlin: integrators at the cell cortex

2002 • 1,301 citations

Blockade of RAGE–amphoterin signalling suppresses tumour growth and metastases

2000 • 1,200 citations

PECAM-1 is required for transendothelial migration of leukocytes.

1993 • 1,134 citations

Leukocyte rolling and extravasation are severely compromised in P selectin-deficient mice

1993 • 1,058 citations

Characterization of caveolin-rich membrane domains isolated from an endothelial-rich source: implications for human disease.

1994 • 912 citations

Control of vascular permeability by polymorphonuclear leukocytes in inflammation

1981 • 850 citations

Leukocyte–endothelial-cell interactions in leukocyte transmigration and the inflammatory response

2003 • 798 citations

The Small GTPases Rho and Rac Are Required for the Establishment of Cadherin-dependent Cell–Cell Contacts

1997 • 772 citations

Rho family proteins: coordinating cell responses

2001 • 763 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 725 citations

Adhesion of human basophils, eosinophils, and neutrophils to interleukin 1-activated human vascular endothelial cells: contributions of endothelial cell adhesion molecules.

1991 • 675 citations

Developing Lymph Nodes Collect CD4 + CD3 − LTβ + Cells That Can Differentiate to APC, NK Cells, and Follicular Cells but Not T or B Cells

1997 • 654 citations

JAM-1 is a ligand of the β2 integrin LFA-1 involved in transendothelial migration of leukocytes

2002 • 636 citations

Regulation mechanism of ERM (ezrin/radixin/moesin) protein/plasma membrane association: possible involvement of phosphatidylinositol turnover and Rho-dependent signaling pathway.

1996 • 601 citations

Dynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent leukocytes

2002 • 581 citations

The Pattern Recognition Receptor (RAGE) Is a Counterreceptor for Leukocyte Integrins

2003 • 556 citations

Susceptibility to Infection and Altered Hematopoiesis in Mice Deficient in Both P- and E-Selectins

1996 • 534 citations

Integrins Regulate Rac Targeting by Internalization of Membrane Domains

2004 • 533 citations

CD99 plays a major role in the migration of monocytes through endothelial junctions

2002 • 497 citations

Two-photon tissue imaging: seeing the immune system in a fresh light

2002 • 482 citations

Glycation, Inflammation, and RAGE

2003 • 476 citations

Roles of Rho-family GTPases in cell polarisation and directional migration

2003 • 467 citations

Rho and Rac but not Cdc42 regulate endothelial cell permeability

2001 • 462 citations

Focal adhesion kinase suppresses Rho activity to promote focal adhesion turnover

2000 • 454 citations

Hematopoietic Progenitor Cell Rolling in Bone Marrow Microvessels: Parallel Contributions by Endothelial Selectins and Vascular Cell Adhesion Molecule 1

1998 • 453 citations

ROCK and Dia have opposing effects on adherens junctions downstream of Rho

2002 • 452 citations

Leukocyte extravasation: chemokine transport and presentation by the endothelium

2002 • 446 citations

Protein Glycation

2004 • 428 citations

Locomotion of monocytes on endothelium is a critical step during extravasation

2004 • 428 citations

Direct Interaction of the Rho GDP Dissociation Inhibitor with Ezrin/Radixin/Moesin Initiates the Activation of the Rho Small G Protein

1997 • 424 citations

Rho-family GTPases in cadherin-mediated cell — cell adhesion

2001 • 424 citations

Neutrophils Emigrate from Venules by a Transendothelial Cell Pathway in Response to FMLP

1998 • 415 citations

Localized Stabilization of Microtubules by Integrin- and FAK-Facilitated Rho Signaling

2004 • 404 citations

Shear forces promote lymphocyte migration across vascular endothelium bearing apical chemokines

2001 • 398 citations

ELECTRON MICROGRAPHIC OBSERVATIONS ON THE EMIGRATION OF LEUCOCYTES

1960 • 388 citations

Characterization of E-selectin-deficient mice: Demonstration of overlapping function of the endothelial selectins

1994 • 384 citations

The formins: active scaffolds that remodel the cytoskeleton

2003 • 370 citations

Role of the cytoskeleton during leukocyte responses

2004 • 348 citations

Endothelial cell cytosolic free calcium regulates neutrophil migration across monolayers of endothelial cells.

1993 • 340 citations

α4-integrin-VCAM-1 binding mediates G protein–independent capture of encephalitogenic T cell blasts to CNS white matter microvessels

2001 • 330 citations

Cell–cell adhesion and signalling

2002 • 327 citations

Function of Rho family proteins in actin dynamics during phagocytosis and engulfment

2000 • 326 citations

Intercellular adhesion molecule 1 (ICAM-1) has a central role in cell-cell contact-mediated immune mechanisms.

1988 • 312 citations

Caveolae and Caveolins in the Cardiovascular System

2004 • 310 citations

Targeted recycling of PECAM from endothelial surface-connected compartments during diapedesis

2003 • 302 citations

Lymphocyte Migration Through Brain Endothelial Cell Monolayers Involves Signaling Through Endothelial ICAM-1 Via a Rho-Dependent Pathway

1999 • 299 citations

ICAM-1-Coupled Cytoskeletal Rearrangements and Transendothelial Lymphocyte Migration Involve Intracellular Calcium Signaling in Brain Endothelial Cell Lines

2000 • 296 citations

Real-Time Imaging of Vascular Endothelial-Cadherin During Leukocyte Transmigration Across Endothelium

2001 • 287 citations

Lung epithelial cell lines in coculture with human pulmonary microvascular endothelial cells: development of an alveolo-capillary barrier in vitro

2004 • 279 citations

The Vesiculo–Vacuolar Organelle (VVO): A New Endothelial Cell Permeability Organelle

2001 • 271 citations

Monocyte Adhesion and Spreading on Human Endothelial Cells Is Dependent on Rho-regulated Receptor Clustering

1999 • 269 citations

ICAM-1 Signaling Pathways Associated with Rho Activation in Microvascular Brain Endothelial Cells

1998 • 252 citations

Signaling in Leukocyte Transendothelial Migration

2004 • 252 citations

Dynamin at the actin–membrane interface

2003 • 241 citations

PECAM-1: old friend, new partners

2003 • 239 citations

Lovastatin inhibits brain endothelial cell Rho‐mediated lymphocyte migration and attenuates experimental autoimmune encephalomyelitis

2003 • 231 citations

Endothelial Cell E- and P-Selectin and Vascular Cell Adhesion Molecule-1 Function as Signaling Receptors

1998 • 230 citations

VCAM-1-mediated Rac signaling controls endothelial cell-cell contacts and leukocyte transmigration

2003 • 229 citations

Neutrophil attractant/activation protein‐1 (interleukin‐8) induces in vitro neutrophil migration by haptotactic mechanism

1993 • 215 citations

Role of Src-induced Dynamin-2 Phosphorylation in Caveolae-mediated Endocytosis in Endothelial Cells

2004 • 211 citations

Vascular-endothelial-cadherin modulates endothelial monolayer permeability

1999 • 209 citations

Endothelial Cells Proactively Form Microvilli-Like Membrane Projections upon Intercellular Adhesion Molecule 1 Engagement of Leukocyte LFA-1

2003 • 207 citations

An anti-platelet-endothelial cell adhesion molecule-1 antibody inhibits leukocyte extravasation from mesenteric microvessels in vivo by blocking the passage through the basement membrane.

1996 • 198 citations

Adhesion molecules in autoimmune disease

1996 • 194 citations

Initiation and Transduction of Stretch-induced RhoA and Rac1 Activation through Caveolae

2003 • 191 citations

Soluble Domain 1 of Platelet–Endothelial Cell Adhesion Molecule (PECAM) Is Sufficient to Block Transendothelial Migration In Vitro and In Vivo

1997 • 184 citations

Lymphocyte Migration Through Monolayers of Endothelial Cell Lines Involves VCAM-1 Signaling Via Endothelial Cell NADPH Oxidase

2000 • 173 citations

Identification of Proteases Involved in the Proteolysis of Vascular Endothelium Cadherin during Neutrophil Transmigration

2003 • 171 citations

A two-step adhesion cascade for T cell/endothelial cell interactions under flow conditions.

1994 • 168 citations

Polarized Distribution of Endogenous Rac1 and RhoA at the Cell Surface

1999 • 165 citations

L- and P-selectins, but not CD49d (VLA-4) integrins, mediate monocyte initial attachment to TNF-alpha-activated vascular endothelium under flow in vitro.

1996 • 157 citations

Monoclonal Antibodies to the Leukocyte Membrane CD18 Glycoprotein Complex and to Intercellular Adhesion Molecule-1 Inhibit Leukocyte-Endothelial Adhesion in Rabbits

1991 • 153 citations

Caveolae — from ultrastructure to molecular mechanisms

2003 • 148 citations

T-cell interaction with ICAM-1/ICAM-2 double-deficient brain endothelium in vitro: the cytoplasmic tail of endothelial ICAM-1 is necessary for transendothelial migration of T cells

2003 • 143 citations

Adherent neutrophils activate endothelial myosin light chain kinase: role in transendothelial migration

1998 • 143 citations

Neutrophils from MMP-9- or neutrophil elastase-deficient mice show no defect in transendothelial migration under flow in vitro

2002 • 138 citations

Eosinophil trafficking to sites of allergic inflammation

2001 • 135 citations

Intercellular Adhesion Molecule (ICAM)-1, But Not ICAM-2, Activates RhoA and Stimulates c-fos and rhoA Transcription in Endothelial Cells

2002 • 132 citations

Endothelial Myosin Light Chain Kinase Regulates Neutrophil Migration Across Human Umbilical Vein Endothelial Cell Monolayer

1998 • 131 citations

Cdc42-dependent Modulation of Tight Junctions and Membrane Protein Traffic in Polarized Madin-Darby Canine Kidney Cells

2001 • 130 citations

Sites of Ca2+ wave initiation move with caveolae to the trailing edge of migrating cells

2002 • 127 citations

Mac-1, but Not LFA-1, Uses Intercellular Adhesion Molecule-1 to Mediate Slow Leukocyte Rolling in TNF-α-Induced Inflammation

2003 • 123 citations

A Molecular Sensor Detects Signal Transduction from Caveolae in Living Cells

2002 • 122 citations

VCAM-1 signals during lymphocyte migration: role of reactive oxygen species

2002 • 121 citations

Ultrastructural studies define soluble macromolecular, particulate, and cellular transendothelial cell pathways in venules, lymphatic vessels, and tumor‐associated microvessels in man and animals

2002 • 121 citations

The p38 Mitogen-Activated Protein Kinase Mediates Cytoskeletal Remodeling in Pulmonary Microvascular Endothelial Cells Upon Intracellular Adhesion Molecule-1 Ligation

2001 • 117 citations

Role of α ₄ Integrin and VCAM-1 in CD18-Independent Neutrophil Migration Across Mouse Cardiac Endothelium

2002 • 108 citations

Interferon‐β stabilizes barrier characteristics of brain endothelial cells in vitro

2004 • 105 citations

Localization of RhoA GTPase to Endothelial Caveolae-Enriched Membrane Domains

1998 • 104 citations

Lymphocyte adhesion-dependent calcium signaling in human endothelial cells.

1995 • 103 citations

Calcium mobilization and Rac1 activation are required for VCAM-1 (vascular cell adhesion molecule-1) stimulation of NADPH oxidase activity

2004 • 103 citations

Migration of Human Hematopoietic Progenitor Cells Across Bone Marrow Endothelium Is Regulated by Vascular Endothelial Cadherin

2002 • 100 citations

Neutrophil-Induced Changes in the Biomechanical Properties of Endothelial Cells: Roles of ICAM-1 and Reactive Oxygen Species

2000 • 100 citations

Stimulated neutrophils induce myosin light chain phosphorylation and isometric tension in endothelial cells

1997 • 99 citations

Shear-dependent Eosinophil Transmigration on Interleukin 4–stimulated Endothelial Cells

2001 • 98 citations

Endothelial Rho and Rho kinase regulate neutrophil migration via endothelial myosin light chain phosphorylation

2002 • 97 citations

Illuminating adhesion complexes in migrating cells: moving toward a bright future

2003 • 95 citations

Myosin Light Chain Phosphorylation in Neutrophil-Stimulated Coronary Microvascular Leakage

2002 • 95 citations

E‐selectin and ICAM‐1 are incorporated into detergent‐insoluble membrane domains following clustering in endothelial cells

2002 • 80 citations

Platelet endothelial cell adhesion molecule‐1 modulates endothelial cell motility through the small G‐protein Rho

2003 • 78 citations

Caveolae and Vesiculo-Vacuolar Organelles in Bovine Capillary Endothelial Cells Cultured with VPF/VEGF on Floating Matrigel-collagen Gels

1999 • 78 citations

Divergent Effects of Platelet-Endothelial Cell Adhesion Molecule-1 and β3 Integrin Blockade on Leukocyte Transmigration In Vivo

2000 • 77 citations

Molecular mechanisms underlying IL-4-induced leukocyte recruitment in vivo: a critical role for the alpha 4 integrin.

1999 • 75 citations

Membrane dynamics in phagocytosis

2001 • 75 citations

Rho regulates association of both the ERM family and vinculin with the plasma membrane in MDCK cells

1997 • 75 citations

Differential movements of VE-cadherin and PECAM-1 during transmigration of polymorphonuclear leukocytes through human umbilical vein endothelium

2002 • 71 citations

The Role of E-Selectin, P-Selectin, and Very Late Activation Antigen-4 in T Lymphocyte Migration to Dermal Inflammation

2002 • 69 citations

Lung Microvascular and Arterial Endothelial Cells Differ in Their Responses to Intercellular Adhesion Molecule-1 Ligation

2002 • 69 citations

Molecular Mechanisms Underlying IL-4-Induced Leukocyte Recruitment In Vivo: A Critical Role for the α4 Integrin

1999 • 67 citations

Lipid Raft Localization of Cell Surface E-Selectin Is Required for Ligation-Induced Activation of Phospholipase Cγ

2003 • 66 citations

Modulation of Endocytic Traffic in Polarized Madin-Darby Canine Kidney Cells by the Small GTPase RhoA

1999 • 65 citations

Selective Alterations in Biosynthetic and Endocytic Protein Traffic in Madin-Darby Canine Kidney Epithelial Cells Expressing Mutants of the Small GTPase Rac1

2000 • 63 citations

Ultrastructural Localization of Platelet Endothelial Cell Adhesion Molecule (PECAM-1, CD31) in Vascular Endothelium

2004 • 63 citations

Identification of Fer Tyrosine Kinase Localized on Microtubules as a Platelet Endothelial Cell Adhesion Molecule-1 Phosphorylating Kinase in Vascular Endothelial Cells

2003 • 62 citations

Human and Murine High Endothelial Venule Cells Phagocytose Apoptotic Leukocytes

1997 • 57 citations

VCAM-1 is more effective than MAdCAM-1 in supporting eosinophil rolling under conditions of shear flow

2000 • 54 citations

Scanning Electron Microscopic Studies on the Route of Neutrophil Extravasation in the Mouse after Exposure to the Chemotactic Peptide N-fonnyl-Methionyl-Leucyl-Phenylalanine (fMLP).

1999 • 42 citations

Signal-dependent distribution of cell surface P-selectin in clathrin-coated pits affects leukocyte rolling under flow

2003 • 39 citations

Measuring actin dynamics in endothelial cells

1998 • 25 citations

Smooth Muscle Cells Influence Monocyte Response to LDL as well as Their Adhesion and Transmigration in a Coculture Model of the Arterial Wall

2001 • 19 citations

HUVEC take up opsonized zymosan particles and secrete cytokines IL-6 and IL-8 in vitro

2003 • 17 citations

Stable lymphocyte contact induces remodeling of endothelial cell matrix receptor complexes

2002 • 12 citations

CD44, α4 integrin, and fucoidin receptor-mediated phagocytosis of apoptotic leukocytes

2003 • 12 citations

An increase in endothelial intracellular calcium and F-actin precedes the extravasation of interleukin-2-activated lymphocytes.

1998 • 8 citations

An Increase in Endothelial Intracellular Calcium and F‐Actin Precedes the Extravasation of Interleukin‐2‐Activated Lymphocytes

1998 • 6 citations