Illuminating adhesion complexes in migrating cells: moving toward a bright future

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

Taking Cell-Matrix Adhesions to the Third Dimension

2001 • 2,940 citations

Force and focal adhesion assembly: a close relationship studied using elastic micropatterned substrates

2001 • 2,089 citations

Creating new fluorescent probes for cell biology

2002 • 1,928 citations

FOCAL ADHESIONS, CONTRACTILITY, AND SIGNALING

1996 • 1,900 citations

Stresses at the Cell-to-Substrate Interface during Locomotion of Fibroblasts

1999 • 1,253 citations

Molecular complexity and dynamics of cell-matrix adhesions

2001 • 1,091 citations

Total Internal Reflection Fluorescence Microscopy in Cell Biology

2001 • 913 citations

Adhesion assembly, disassembly and turnover in migrating cells – over and over and over again

2002 • 741 citations

Nascent Focal Adhesions Are Responsible for the Generation of Strong Propulsive Forces in Migrating Fibroblasts

2001 • 724 citations

Localized Rac Activation Dynamics Visualized in Living Cells

2000 • 667 citations

G Protein Signaling Events Are Activated at the Leading Edge of Chemotactic Cells

1998 • 626 citations

Interplay between Rac and Rho in the control of substrate contact dynamics

1999 • 623 citations

Dynamics and segregation of cell–matrix adhesions in cultured fibroblasts

2000 • 574 citations

Activation of Rac and Cdc42 Video Imaged by Fluorescent Resonance Energy Transfer-Based Single-Molecule Probes in the Membrane of Living Cells

2002 • 558 citations

Integrin Dynamics and Matrix Assembly

2000 • 459 citations

Molecular diversity of cell-matrix adhesions

1999 • 444 citations

Differential Dynamics of α5 Integrin, Paxillin, and α-Actinin during Formation and Disassembly of Adhesions in Migrating Cells

2001 • 439 citations

Physical State of the Extracellular Matrix Regulates the Structure and Molecular Composition of Cell-Matrix Adhesions

2000 • 402 citations

A micromachined device provides a new bend on fibroblast traction forces

1997 • 396 citations

Marching at the front and dragging behind

2001 • 358 citations

Fluorescent speckle microscopy, a method to visualize the dynamics of protein assemblies in living cells

1998 • 338 citations

Collective cell movement in primary melanoma explants: plasticity of cell-cell interaction, beta1-integrin function, and migration strategies.

2002 • 314 citations

Forces on adhesive contacts affect cell function

1998 • 271 citations

Rac recruits high-affinity integrin αvβ3 to lamellipodia in endothelial cell migration

2001 • 261 citations

Physical and biochemical regulation of integrin release during rear detachment of migrating cells

1998 • 260 citations

Dynamics of beta 1 integrin-mediated adhesive contacts in motile fibroblasts.

1992 • 222 citations

Fluorescence correlations, single molecule detection and large number screening Applications in biotechnology

1995 • 215 citations

The inner lives of focal adhesions

2002 • 206 citations

GIT1 functions in a motile, multi-molecular signaling complex that regulates protrusive activity and cell migration

2002 • 197 citations

Dissecting the link between stress fibres and focal adhesions by CALI with EGFP fusion proteins

2002 • 187 citations

Integrin dynamics on the tail region of migrating fibroblasts

1996 • 175 citations

Two‐photon image correlation spectroscopy and image cross‐correlation spectroscopy

2000 • 172 citations

Spatial and Temporal Analysis of Rac Activation during Live Neutrophil Chemotaxis

2002 • 167 citations

Solvent-Sensitive Dyes to Report Protein Conformational Changes in Living Cells

2003 • 156 citations

Fluorescence Correlation Spectroscopy Measures Molecular Transport in Cells

2001 • 131 citations

The composition and dynamics of cell-substratum adhesions in locomoting fish keratocytes

1997 • 130 citations

A fluorescent resonant energy transfer–based biosensor reveals transient and regional myosin light chain kinase activation in lamella and cleavage furrows

2002 • 119 citations

Visualizing muscle cell migration in situ

2000 • 106 citations

Live-cell monitoring of tyrosine phosphorylation in focal adhesions following microtubule disruption

2003 • 105 citations

Analysis of membrane protein cluster densities and sizes in situ by image correlation spectroscopy

1999 • 62 citations

Molecular mechanisms regulating the subcellular localization of p95-APP1 between the endosomal recycling compartment and sites of actin organization at the cell surface

2001 • 56 citations

Live-cell fluorescent biosensors for activated signaling proteins

2002 • 46 citations

Identification of a Novel Microtubule-Associated Protein that Regulates Microtubule Organization and Cytokinesis by Using a GFP-Screening Strategy

2002 • 18 citations