Ultrastructural Localization of Platelet Endothelial Cell Adhesion Molecule (PECAM-1, CD31) in Vascular Endothelium

Leukocyte-endothelial adhesion molecules

1994 • 2,567 citations

Leukocyte-endothelial adhesion molecules

1994 • 1,884 citations

Cold Spring Harbor Symposia on Quantitative Biology.

1989 • 1,160 citations

PECAM-1 is required for transendothelial migration of leukocytes.

1993 • 1,134 citations

Molecular and cellular properties of PECAM-1 (endoCAM/CD31): a novel vascular cell-cell adhesion molecule.

1991 • 719 citations

The biology of PECAM-1.

1997 • 669 citations

A novel endothelial-specific membrane protein is a marker of cell-cell contacts.

1992 • 637 citations

Involvement of endothelial PECAM-1/CD31 in angiogenesis.

1997 • 539 citations

Involvement of Platelet-Endothelial Cell Adhesion Molecule-1 in Neutrophil Recruitment in Vivo

1993 • 468 citations

Heterogeneity of the Angiogenic Response Induced in Different Normal Adult Tissues by Vascular Permeability Factor/Vascular Endothelial Growth Factor

2000 • 421 citations

Neutrophils Emigrate from Venules by a Transendothelial Cell Pathway in Response to FMLP

1998 • 415 citations

EndoCAM: a novel endothelial cell-cell adhesion molecule.

1990 • 409 citations

Signal Transduction Pathways Mediated by PECAM-1

2003 • 380 citations

A human endothelial cell-restricted, externally disposed plasmalemmal protein enriched in intercellular junctions.

1989 • 365 citations

Monoclonal antibodies specific for endothelial cells of mouse blood vessels. Their application in the identification of adult and embryonic endothelium.

1994 • 315 citations

Targeted recycling of PECAM from endothelial surface-connected compartments during diapedesis

2003 • 302 citations

Platelet endothelial cell adhesion molecule-1 (PECAM-1 / CD31): alternatively spliced, functionally distinct isoforms expressed during mammalian cardiovascular development

1994 • 301 citations

Altered vascular permeability and early onset of experimental autoimmune encephalomyelitis in PECAM-1–deficient mice

2002 • 290 citations

Vesiculo-vacuolar organelles and the regulation of venule permeability to macromolecules by vascular permeability factor, histamine, and serotonin.

1996 • 280 citations

The vesiculo-vacuolar organelle (VVO): a distinct endothelial cell structure that provides a transcellular pathway for macromolecular extravasation

1996 • 266 citations

Altered vascular permeability and early onset of experimental autoimmune encephalomyelitis in PECAM-1–deficient mice

2002 • 261 citations

Migration of monocytes across endothelium and passage through extracellular matrix involve separate molecular domains of PECAM-1.

1995 • 240 citations

Receptor-mediated cellular entry of nuclear localizing anti-DNA antibodies via myosin 1.

1997 • 235 citations

Involvement of human PECAM-1 in angiogenesis and in vitro endothelial cell migration

2002 • 206 citations

Migration of leukocytes across endothelium and beyond: molecules involved in the transmigration and fate of monocytes

1999 • 204 citations

Spatial and temporal relationships between cadherins and PECAM-1 in cell-cell junctions of human endothelial cells.

1994 • 196 citations

The role of PECAM-1 (CD31) in leukocyte emigration: studies in vitro and in vivo

1995 • 183 citations

Pathways of Macromolecular Extravasation Across Microvascular Endothelium in Response to VPF/VEGF and Other Vasoactive Mediators

1999 • 180 citations

The unfolding tale of PECAM‐1

2003 • 174 citations

Immunoelectron Microscopic Characterization of Human Dermal Lymphatic Microvascular Endothelial Cells: Differential Expression of CD31, CD34, and Type IV Collagen with Lymphatic Endothelial Cells vs Blood Capillary Endothelial Cells in Normal Human Skin, Lymphangioma, and Hemangioma In Situ

1998 • 165 citations

A New Role for Platelet-Endothelial Cell Adhesion Molecule-1 (CD31): Inhibition of TCR-Mediated Signal Transduction

1999 • 154 citations

Platelet endothelial cell adhesion molecule-1 signaling inhibits the activation of human platelets

2002 • 150 citations

The Role of PECAM‐1 in Vascular Cell Biology^a

1994 • 148 citations

Activation-dependent changes in human platelet PECAM-1: phosphorylation, cytoskeletal association, and surface membrane redistribution.

1992 • 137 citations

PECAM‐1 shedding during apoptosis generates a membrane‐anchored truncated molecule with unique signaling characteristics

2001 • 131 citations

Inhibition of antigen-receptor signaling by Platelet Endothelial Cell Adhesion Molecule-1 (CD31) requires functional ITIMs, SHP-2, and p56lck

2001 • 126 citations

Ultrastructural studies define soluble macromolecular, particulate, and cellular transendothelial cell pathways in venules, lymphatic vessels, and tumor‐associated microvessels in man and animals

2002 • 121 citations

Platelet endothelial cell adhesion molecule, PECAM‐1, modulates cell migration

1992 • 120 citations

Reinterpretation of endothelial cell gaps induced by vasoactive mediators in guinea‐fig, mouse and rat: many are transcellular pores

1997 • 120 citations

Ultrastructural Localization of the Vascular Permeability Factor/Vascular Endothelial Growth Factor (VPF/VEGF) Receptor-2 (FLK-1, KDR) in Normal Mouse Kidney and in the Hyperpermeable Vessels Induced by VPF/VEGF-expressing Tumors and Adenoviral Vectors

2000 • 119 citations

Inhibition of platelet endothelial cell adhesion molecule-1 synthesis and leukocyte transmigration in endothelial cells by the combined action of TNF-alpha and IFN-gamma.

1996 • 112 citations

Blockade of platelet endothelial cell adhesion molecule-1 protects against myocardial ischemia and reperfusion injury in cats.

1996 • 110 citations

Neutrophil platelet endothelial cell adhesion molecule-1 participates in neutrophil recruitment at inflammatory sites and is down-regulated after leukocyte extravasation.

1997 • 103 citations

Deletions in the cytoplasmic domain of platelet-endothelial cell adhesion molecule-1 (PECAM-1, CD31) result in changes in ligand binding properties

1994 • 100 citations

Different Pathways of Macromolecule Extravasation from Hyperpermeable Tumor Vessels

2000 • 100 citations

A novel leukocyte differentiation antigen: two monoclonal antibodies TM2 and TM3 define a 120-kd molecule present on neutrophils, monocytes, platelets, and activated lymphoblasts

1985 • 96 citations

VEGF-A Induces Angiogenesis, Arteriogenesis, Lymphangiogenesis, and Vascular Malformations

2002 • 94 citations

CD31/PECAM‐1‐driven chemokine‐independent transmigration of human T lymphocytes

1996 • 90 citations

Alternative Splicing of a Specific Cytoplasmic Exon Alters the Binding Characteristics of Murine Platelet/Endothelial Cell Adhesion Molecule-1 (PECAM-1)

1995 • 85 citations

Src Homology 2 Domain-Containing Protein-Tyrosine Phosphatases, SHP-1 and SHP-2, Are Required for Platelet Endothelial Cell Adhesion Molecule-1/CD31-Mediated Inhibitory Signaling

2001 • 79 citations

Antibody against murine PECAM-1 inhibits tumor angiogenesis in mice.

1999 • 74 citations

Association of murine CD31 with transmigrating lymphocytes following antigenic stimulation.

1992 • 74 citations

Biochemical Characterization of PECAM-1 (CD31 Antigen) on Human Platelets

1991 • 65 citations

PECAM-1–dependent neutrophil transmigration is independent of monolayer PECAM-1 signaling or localization

2003 • 64 citations

Tissue specific expression of alternatively spliced Murine PECAM-1 isoforms

1999 • 52 citations

Phenotype of Normal Cutaneous Microvasculature

1996 • 50 citations

Platelet/endothelial cell adhesion molecule-1 (PECAM-1) is localized over the entire plasma membrane of endothelial cells

1997 • 49 citations

Isolation and characterization of macrovascular and microvascular endothelial cells from human hearts

1994 • 48 citations

Tyrosine Residue in Exon 14 of the Cytoplasmic Domain of Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1/CD31) Regulates Ligand Binding Specificity

1997 • 45 citations

Transgenic Mice Expressing Different Levels of Soluble Platelet/Endothelial Cell Adhesion Molecule-IgG Display Distinct Inflammatory Phenotypes

1999 • 43 citations

Immunoelectron microscopic study of PECAM-1 expression on lymphatic endothelium of the human tongue

2001 • 20 citations

Ultrastructural and Morphometric Studies Related to Expression of the Cell Adhesion Molecule PECAM-1/CD31 in Developing Rat Lung

2000 • 16 citations

Immunoultrastructural Expression of ICAM-1 and PECAM-1 Occurs Prior to Structural Maturity of the Murine Blood-Brain Barrier

1998 • 14 citations

The use of anti-Pecam Reagents in the Control of Inflammation

1995 • 10 citations

TNFα Induces E-Selectin Expression and PECAM-1 (CD31) Redistribution in Extracutaneous Tissues

1993 • 9 citations