The formins: active scaffolds that remodel the cytoskeleton

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

1997 • 71,835 citations

Rho GTPases in cell biology

2002 • 4,662 citations

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

Cellular Motility Driven by Assembly and Disassembly of Actin Filaments

2003 • 4,038 citations

A homochiral metal–organic porous material for enantioselective separation and catalysis

2000 • 3,832 citations

Focal Contacts as Mechanosensors

2001 • 1,390 citations

The Interaction between N-WASP and the Arp2/3 Complex Links Cdc42-Dependent Signals to Actin Assembly

1999 • 1,332 citations

Actin Dynamics Control SRF Activity by Regulation of Its Coactivator MAL

2003 • 1,286 citations

The Rho family GTPases RhoA, Racl , and CDC42Hsregulate transcriptional activation by SRF

1995 • 1,280 citations

Guanine nucleotide exchange factors for Rho GTPases: turning on the switch

2002 • 1,225 citations

Cooperation between mDia1 and ROCK in Rho-induced actin reorganization

1999 • 884 citations

Activation of Cardiac Gene Expression by Myocardin, a Transcriptional Cofactor for Serum Response Factor

2001 • 883 citations

p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin

1997 • 819 citations

Wnt/Frizzled Activation of Rho Regulates Vertebrate Gastrulation and Requires a Novel Formin Homology Protein Daam1

2001 • 807 citations

Mechanism of filopodia initiation by reorganization of a dendritic network

2003 • 761 citations

Role of Formins in Actin Assembly: Nucleation and Barbed-End Association

2002 • 740 citations

Autoinhibition and activation mechanisms of the Wiskott–Aldrich syndrome protein

2000 • 739 citations

Signal-Regulated Activation of Serum Response Factor Is Mediated by Changes in Actin Dynamics

1999 • 656 citations

Bni1p, a Yeast Formin Linking Cdc42p and the Actin Cytoskeleton During Polarized Morphogenesis

1997 • 654 citations

A Conserved Binding Motif Defines Numerous Candidate Target Proteins for Both Cdc42 and Rac GTPases

1995 • 625 citations

[30] Prediction and analysis of coiled-coil structures

1996 • 574 citations

mDia mediates Rho-regulated formation and orientation of stable microtubules

2001 • 566 citations

Assembly and mechanosensory function of focal contacts

2001 • 548 citations

An actin nucleation mechanism mediated by Bni1 and Profilin

2002 • 475 citations

WW and SH3 domains, two different scaffolds to recognize proline‐rich ligands

2001 • 474 citations

Formins direct Arp2/3-independent actin filament assembly to polarize cell growth in yeast

2001 • 472 citations

Negative Regulation of Fibroblast Motility by Ena/VASP Proteins

2000 • 460 citations

ROCK and Dia have opposing effects on adherens junctions downstream of Rho

2002 • 452 citations

The Mouse Formin mDia1 Is a Potent Actin Nucleation Factor Regulated by Autoinhibition

2003 • 430 citations

cdc12p, a Protein Required for Cytokinesis in Fission Yeast, Is a Component of the Cell Division Ring and Interacts with Profilin

1997 • 415 citations

Nonsyndromic Deafness DFNA1 Associated with Mutation of a Human Homolog of the Drosophila Gene diaphanous

1997 • 409 citations

diaphanous is required for cytokinesis in Drosophila and shares domains of similarity with the products of the limb deformity gene

1994 • 408 citations

Yeast formins regulate cell polarity by controlling the assembly of actin cables

2001 • 396 citations

Diaphanous-Related Formins Bridge Rho GTPase and Src Tyrosine Kinase Signaling

2000 • 379 citations

Role of Actin Polymerization and Adhesion to Extracellular Matrix in Rac- and Rho-induced Cytoskeletal Reorganization

1997 • 378 citations

In mouse brain profilin I and profilin II associate with regulators of the endocytic pathway and actin assembly

1998 • 353 citations

Coordination of microtubules and the actin cytoskeleton by the Rho effector mDia1

2000 • 350 citations

The fission yeast cytokinesis formin Cdc12p is a barbed end actin filament capping protein gated by profilin

2003 • 337 citations

Formin-2, polyploidy, hypofertility and positioning of the meiotic spindle in mouse oocytes

2002 • 323 citations

Identification of a Carboxyl-terminal Diaphanous-related Formin Homology Protein Autoregulatory Domain

2001 • 322 citations

Isolation and characterization of fission yeast mutants defective in the assembly and placement of the contractile actin ring

1996 • 311 citations

Bni1p and Bnr1p: downstream targets of the Rho family small G-proteins which interact with profilin and regulate actin cytoskeleton in Saccharomyces cerevisiae

1997 • 309 citations

Myosin V orientates the mitotic spindle in yeast

2000 • 301 citations

Mother Cell–Specific HO Expression in Budding Yeast Depends on the Unconventional Myosin Myo4p and Other Cytoplasmic Proteins

1996 • 299 citations

Bni1p implicated in cytoskeletal control is a putative target of Rho1p small GTP binding protein in Saccharomyces cerevisiae.

1996 • 284 citations

Elongation factor 1α, translation and the cytoskeleton

1995 • 273 citations

Disruption of the Diaphanous-Related Formin Drf1 Gene Encoding mDia1 Reveals a Role for Drf3 as an Effector for Cdc42

2003 • 262 citations

Asymmetric Loading of Kar9 onto Spindle Poles and Microtubules Ensures Proper Spindle Alignment

2003 • 254 citations

A Human Homologue of the Drosophila melanogaster diaphanous Gene Is Disrupted in a Patient with Premature Ovarian Failure: Evidence for Conserved Function in Oogenesis and Implications for Human Sterility

1998 • 251 citations

Altered phosphorylation and activation of PP60c-src during fibroblast mitosis

1988 • 249 citations

Roles of the fission yeast formin for3p in cell polarity, actin cable formation and symmetric cell division

2001 • 249 citations

Protein elongation factor EEF1A2 is a putative oncogene in ovarian cancer

2002 • 246 citations

Mechanism of Formin-Induced Nucleation of Actin Filaments

2002 • 238 citations

The essential role of profilin in the assembly of actin for microspike formation

1998 • 237 citations

Association of p60c-src with endosomal membranes in mammalian fibroblasts.

1992 • 233 citations

RhoD regulates endosome dynamics through Diaphanous-related Formin and Src tyrosine kinase

2003 • 223 citations

Localization and anchoring of mRNA in budding yeast

1999 • 219 citations

Analysis of RhoA-binding Proteins Reveals an Interaction Domain Conserved in Heterotrimeric G Protein β Subunits and the Yeast Response Regulator Protein Skn7

1998 • 208 citations

A Formin Homology Protein and a Profilin Are Required for Cytokinesis and Arp2/3-Independent Assembly of Cortical Microfilaments in C. elegans

2002 • 208 citations

'Formins': proteins deduced from the alternative transcripts of the limb deformity gene

1990 • 201 citations

LIM kinase and Diaphanous cooperate to regulate serum response factor and actin dynamics

2002 • 197 citations

FH proteins as cytoskeletal organizers

1998 • 195 citations

Rho3 of Saccharomyces cerevisiae, Which Regulates the Actin Cytoskeleton and Exocytosis, Is a GTPase Which Interacts with Myo2 and Exo70

1999 • 194 citations

Differential Usage of Signal Transduction Pathways Defines Two Types of Serum Response Factor Target Gene

2001 • 193 citations

Actin cable dynamics in budding yeast

2002 • 192 citations

The Diaphanous-related Formin mDia1 Controls Serum Response Factor Activity through its Effects on Actin Polymerization

2002 • 188 citations

Coordination of cell polarization and migration by the Rho family GTPases requires Src tyrosine kinase activity

2001 • 184 citations

Regulating the actin cytoskeleton during vesicular transport

2002 • 182 citations

Interactions of Elongation Factor 1α with F-Actin and β-Actin mRNA: Implications for Anchoring mRNA in Cell Protrusions

2002 • 174 citations

Contingent Phosphorylation/Dephosphorylation Provides a Mechanism of Molecular Memory in WASP

2003 • 173 citations

Evolutionary conservation of microtubule-capture mechanisms

2002 • 168 citations

Distinct Actions and Cooperative Roles of ROCK and mDia in Rho Small G Protein-induced Reorganization of the Actin Cytoskeleton in Madin–Darby Canine Kidney Cells

1999 • 165 citations

FH3, A Domain Found in Formins, Targets the Fission Yeast Formin Fus1 to the Projection Tip During Conjugation

1998 • 161 citations

Formins: intermediates in signal-transduction cascades that affect cytoskeletal reorganization

2002 • 160 citations

Cappuccino, a Drosophila maternal effect gene required for polarity of the egg and embryo, is related to the vertebrate limb deformity locus.

1995 • 159 citations

Control of Mitotic Spindle Position by the Saccharomyces cerevisiae Formin Bni1p

1999 • 154 citations

Dynamic Localization and Function of Bni1p at the Sites of Directed Growth in Saccharomyces cerevisiae

2001 • 153 citations

Phosphorylation of the WASP-VCA Domain Increases Its Affinity for the Arp2/3 Complex and Enhances Actin Polymerization by WASP

2003 • 149 citations

Rho1 Directs Formin-Mediated Actin Ring Assembly during Budding Yeast Cytokinesis

2002 • 148 citations

Polarized growth and organelle segregation in yeast

2003 • 147 citations

A Novel Neural Wiskott-Aldrich Syndrome Protein (N-Wasp) Binding Protein, Wish, Induces Arp2/3 Complex Activation Independent of Cdc42

2001 • 147 citations

Actin dynamics in growth cones

1991 • 145 citations

Identification of a Novel Family of Targets of PYK2 Related to Drosophila Retinal Degeneration B (rdgB) Protein

1999 • 139 citations

The Aspergillus nidulans sepA gene encodes an FH1/2 protein involved in cytokinesis and the maintenance of cellular polarity

1997 • 135 citations

Localization of a mammalian homolog of diaphanous, mDia1, to the mitotic spindle in HeLa cells

2001 • 124 citations

cyk-1: a C. elegans FH gene required for a late step in embryonic cytokinesis

1998 • 124 citations

Immunolocalization of the cellular src protein in interphase and mitotic NIH c-src overexpresser cells.

1990 • 120 citations

Characterization offus1ofSchizosaccharomyces pombe: a Developmentally Controlled Function Needed for Conjugation

1995 • 114 citations

Actin cytoskeleton: Are FH proteins local organizers?

1997 • 114 citations

Delphilin: a Novel PDZ and Formin Homology Domain-Containing Protein that Synaptically Colocalizes and Interacts with Glutamate Receptor δ2 Subunit

2002 • 109 citations

Bundling of actin filaments by elongation factor 1 alpha inhibits polymerization at filament ends.

1996 • 109 citations

Effect of capping protein on the kinetics of actin polymerization

1985 • 108 citations

FRL, a Novel Formin-Related Protein, Binds to Rac and Regulates Cell Motility and Survival of Macrophages

2000 • 104 citations

A Rho-dependent signaling pathway operating through myosin localizes β-actin mRNA in fibroblasts

2001 • 93 citations

The Cdc42p GTPase Is Involved in a G2/M Morphogenetic Checkpoint Regulating the Apical-Isotropic Switch and Nuclear Division in Yeast

1999 • 92 citations

The Formin/Diaphanous-related Protein, FHOS, Interacts with Rac1 and Activates Transcription from the Serum Response Element

2001 • 90 citations

mDia-interacting Protein Acts Downstream of Rho-mDia and Modifies Src Activation and Stress Fiber Formation

2001 • 85 citations

Movement of a cytokinesis factor cdc12p to the site of cell division

1999 • 82 citations

Rho Small G-Protein-Dependent Binding of mDia to an Src Homology 3 Domain-Containing IRSp53/BAIAP2

2000 • 80 citations

Gic2p May Link Activated Cdc42p to Components Involved in Actin Polarization, Including Bni1p and Bud6p (Aip3p)

2000 • 80 citations

Axon guidance: receptor complexes and signaling mechanisms

2002 • 80 citations

Interaction of Rho1p target Bni1p with F-actin-binding elongation factor 1α: implication in Rho1p-regulated reorganization of the actin cytoskeleton in Saccharomyces cerevisiae

1998 • 68 citations

Formin-2, a novel formin homology protein of the cappuccino subfamily, is highly expressed in the developing and adult central nervous system

2000 • 67 citations

Elongation Factor-1α Is a Novel Substrate of Rho-Associated Kinase

2000 • 66 citations

The chicken limb deformity gene encodes nuclear proteins expressed in specific cell types during morphogenesis.

1992 • 63 citations

SPIN90 (SH3 ProteinInteracting with Nck, 90 kDa), an Adaptor Protein That Is Developmentally Regulated during Cardiac Myocyte Differentiation

2001 • 52 citations

Interaction of Serum Response Factor (SRF) with the Elk-1 B Box Inhibits RhoA-Actin Signaling to SRF and Potentiates Transcriptional Activation by Elk-1

2002 • 51 citations

Phosphorylation of the Src substrate Sam68 by Cdc2 during mitosis

1997 • 51 citations

Identification and characterization of a protein containing formin homology (FH1/FH2) domains

1999 • 51 citations

Bni1p Regulates Microtubule-Dependent Nuclear Migration through the Actin Cytoskeleton in Saccharomyces cerevisiae

1999 • 50 citations

A variant limb deformity transcript expressed in the embryonic mouse limb defines a novel formin.

1992 • 47 citations

Distinct roles of profilin in cell morphological changes: microspikes, membrane ruffles, stress fibers, and cytokinesis

1999 • 46 citations

ForC, a novel type of formin family protein lacking an FH1 domain, is involved in multicellular development inDictyostelium discoideum

2003 • 41 citations

The social life of actin and microtubules: interaction versus cooperation

2001 • 35 citations

Molecular Interaction between Limb Deformity Proteins (Formins) and Src Family Kinases

1996 • 34 citations

GTPase Signalling: New Functions for Diaphanous-Related Formins

2003 • 21 citations

Nir2, a Novel Regulator of Cell Morphogenesis

2002 • 20 citations

Structure of AF3p21, a New Member of Mixed Lineage Leukemia (MLL) Fusion Partner Proteins-Implication for MLL-Induced Leukemogenesis

2001 • 18 citations

The sequence of a 24 152 bp segment from the left arm of chromosome XIV from Saccharomyces cerevisiae between the BNI1 and the POL2 genes

1996 • 4 citations