ERM proteins and merlin: integrators at the cell cortex

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

1994 • 63,397 citations

A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor

1993 • 1,376 citations

Alteration in a new gene encoding a putative membrane-organizing protein causes neuro-fibromatosis type 2

1993 • 1,360 citations

The Interaction between N-WASP and the Arp2/3 Complex Links Cdc42-Dependent Signals to Actin Assembly

1999 • 1,332 citations

Rho-Kinase Phosphorylates COOH-terminal Threonines of Ezrin/Radixin/Moesin (ERM) Proteins and Regulates Their Head-to-Tail Association

1998 • 849 citations

ERM family members as molecular linkers between the cell surface glycoprotein CD44 and actin-based cytoskeletons.

1994 • 790 citations

Structural and Evolutionary Relationships among Protein Tyrosine Phosphatase Domains

2001 • 694 citations

A kinase-regulated PDZ-domain interaction controls endocytic sorting of the β2-adrenergic receptor

1999 • 673 citations

Regulation mechanism of ERM (ezrin/radixin/moesin) protein/plasma membrane association: possible involvement of phosphatidylinositol turnover and Rho-dependent signaling pathway.

1996 • 601 citations

Structure of the ERM Protein Moesin Reveals the FERM Domain Fold Masked by an Extended Actin Binding Tail Domain

2000 • 594 citations

Ezrin/Radixin/Moesin (ERM) Proteins Bind to a Positively Charged Amino Acid Cluster in the Juxta-Membrane Cytoplasmic Domain of CD44, CD43, and ICAM-2

1998 • 592 citations

The β2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange

1998 • 582 citations

Identification of EBP50: A PDZ-containing Phosphoprotein that Associates with Members of the Ezrin-Radixin-Moesin Family

1997 • 582 citations

The NF2 tumor suppressor gene product, merlin, mediates contact inhibition of growth through interactions with CD44

2001 • 546 citations

The FERM domain: a unique module involved in the linkage of cytoplasmic proteins to the membrane

1998 • 530 citations

An Apical PDZ Protein Anchors the Cystic Fibrosis Transmembrane Conductance Regulator to the Cytoskeleton

1998 • 472 citations

Cortical Actin Organization: Lessons from ERM (Ezrin/Radixin/Moesin) Proteins

1999 • 464 citations

cAMP-mediated inhibition of the epithelial brush border Na ⁺ /H ⁺ exchanger, NHE3, requires an associated regulatory protein

1997 • 426 citations

Ezrin is concentrated in the apical microvilli of a wide variety of epithelial cells whereas moesin is found primarily in endothelial cells

1993 • 426 citations

Direct Interaction of the Rho GDP Dissociation Inhibitor with Ezrin/Radixin/Moesin Initiates the Activation of the Rho Small G Protein

1997 • 424 citations

Ezrin self-association involves binding of an N-terminal domain to a normally masked C-terminal domain that includes the F-actin binding site.

1995 • 422 citations

Direct Binding of the Na–H Exchanger NHE1 to ERM Proteins Regulates the Cortical Cytoskeleton and Cell Shape Independently of H+ Translocation

2000 • 407 citations

A C-terminal motif found in the β ₂ -adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na ⁺ /H ⁺ exchanger regulatory factor family of PDZ proteins

1998 • 406 citations

Ezrin has a COOH-terminal actin-binding site that is conserved in the ezrin protein family.

1994 • 395 citations

Rapid phosphorylation and reorganization of ezrin and spectrin accompany morphological changes induced in A-431 cells by epidermal growth factor.

1989 • 385 citations

Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumors

1998 • 381 citations

Structural basis of the membrane-targeting and unmasking mechanisms of the radixin FERM domain

2000 • 380 citations

ERM-Merlin and EBP50 Protein Families in Plasma Membrane Organization and Function

2000 • 375 citations

F-actin binding site masked by the intramolecular association of vinculin head and tail domains

1995 • 371 citations

ERM proteins in cell adhesion and membrane dynamics

1999 • 364 citations

Perturbation of cell adhesion and microvilli formation by antisense oligonucleotides to ERM family members.

1994 • 347 citations

The Nf2 Tumor Suppressor, Merlin, Functions in Rac-Dependent Signaling

2001 • 344 citations

A gene family consisting of ezrin, radixin and moesin Its specific localization at actin filament/plasma membrane association sites

1992 • 334 citations

The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho

2000 • 325 citations

Association of Ezrin with Intercellular Adhesion Molecule-1 and -2 (ICAM-1 and ICAM-2)

1998 • 325 citations

Identification of a Carboxyl-terminal Diaphanous-related Formin Homology Protein Autoregulatory Domain

2001 • 322 citations

Ezrin, a plasma membrane–microfilament linker, signals cell survival through the phosphatidylinositol 3-kinase/Akt pathway

1999 • 319 citations

Stabilizing Infrastructure of Cell Membranes

1985 • 317 citations

Ezrin Is an Effector of Hepatocyte Growth Factor–mediated Migration and Morphogenesis in Epithelial Cells

1997 • 317 citations

Ezrin is a cyclic AMP-dependent protein kinase anchoring protein

1997 • 309 citations

Rho- and Rac-dependent Assembly of Focal Adhesion Complexes and Actin Filaments in Permeabilized Fibroblasts: An Essential Role for Ezrin/Radixin/Moesin Proteins

1997 • 303 citations

Purification of an 80,000-dalton protein that is a component of the isolated microvillus cytoskeleton, and its localization in nonmuscle cells.

1983 • 294 citations

Ezrin is a downstream effector of trafficking PKC-integrin complexes involved in the control of cell motility

2001 • 287 citations

Peptide binding consensus of the NHE‐RF‐PDZ1 domain matches the C‐terminal sequence of cystic fibrosis transmembrane conductance regulator (CFTR)

1998 • 278 citations

Morphogenic Effects of Ezrin Require a Phosphorylation-Induced Transition from Oligomers to Monomers at the Plasma Membrane

2000 • 274 citations

p21-activated Kinase Links Rac/Cdc42 Signaling to Merlin

2002 • 271 citations

Exclusion of CD43 from the Immunological Synapse Is Mediated by Phosphorylation-Regulated Relocation of the Cytoskeletal Adaptor Moesin

2001 • 270 citations

NHE3 Kinase A Regulatory Protein E3KARP Binds the Epithelial Brush Border Na+/H+ Exchanger NHE3 and the Cytoskeletal Protein Ezrin

1998 • 269 citations

Activation of ERM proteins in vivo by Rho involves phosphatidyl-inositol 4-phosphate 5-kinase and not ROCK kinases

1999 • 255 citations

Merlin Phosphorylation by p21-activated Kinase 2 and Effects of Phosphorylation on Merlin Localization

2002 • 255 citations

Loss of glomerular foot processes is associated with uncoupling of podocalyxin from the actin cytoskeleton

2001 • 254 citations

cDNA cloning and sequencing of the protein-tyrosine kinase substrate, ezrin, reveals homology to band 4.1.

1989 • 253 citations

Moesin: a member of the protein 4.1-talin-ezrin family of proteins.

1991 • 250 citations

ERM-Dependent Movement of CD43 Defines a Novel Protein Complex Distal to the Immunological Synapse

2001 • 247 citations

Rho-dependent and -independent activation mechanisms of ezrin/radixin/moesin proteins: an essential role for polyphosphoinositides in vivo

2002 • 240 citations

A novel PKC-regulated mechanism controls CD44–ezrin association and directional cell motility

2002 • 239 citations

Moesin Interacts with the Cytoplasmic Region of Intercellular Adhesion Molecule-3 and Is Redistributed to the Uropod of T Lymphocytes during Cell Polarization

1997 • 238 citations

Interdomain binding mediates tumor growth suppression by the NF2 gene product

1997 • 234 citations

Mutagenesis of the Phosphatidylinositol 4,5-Bisphosphate (Pip2) Binding Site in the Nh2-Terminal Domain of Ezrin Correlates with Its Altered Cellular Distribution

2000 • 234 citations

ICAM-2 redistributed by ezrin as a target for killer cells

1996 • 233 citations

Phosphorylation of Moesin by Rho-associated Kinase (Rho-kinase) Plays a Crucial Role in the Formation of Microvilli-like Structures

1998 • 229 citations

CD95 (APO-1/Fas) linkage to the actin cytoskeleton through ezrin in human T lymphocytes: a novel regulatory mechanism of the CD95 apoptotic pathway

2000 • 217 citations

Nf2 gene inactivation in arachnoidal cells is rate-limiting for meningioma development in the mouse

2002 • 214 citations

Protein Kinase C-θ Phosphorylation of Moesin in the Actin-binding Sequence

1998 • 213 citations

A new 82-kD barbed end-capping protein (radixin) localized in the cell-to-cell adherens junction: purification and characterization.

1989 • 211 citations

Association of the Myosin-binding Subunit of Myosin Phosphatase and Moesin: Dual Regulation of Moesin Phosphorylation by Rho-associated Kinase and Myosin Phosphatase

1998 • 210 citations

Ezrin oligomers are major cytoskeletal components of placental microvilli: a proposal for their involvement in cortical morphogenesis.

1995 • 208 citations

Platelet-Derived Growth Factor Receptor Association with Na⁺/H⁺ Exchanger Regulatory Factor Potentiates Receptor Activity

2000 • 206 citations

Phosphorylation of Threonine 558 in the Carboxyl-terminal Actin-binding Domain of Moesin by Thrombin Activation of Human Platelets

1995 • 205 citations

The Nf2 tumor suppressor gene product is essential for extraembryonic development immediately prior to gastrulation.

1997 • 202 citations

Identification of a phosphatidylinositol‐4,5‐bisphosphate‐binding domain in the N‐terminal region of ezrin

1995 • 198 citations

The Carboxyl-terminal Region of EBP50 Binds to a Site in the Amino-terminal Domain of Ezrin That Is Masked in the Dormant Molecule

1998 • 194 citations

The Membrane-Microfilament Linker Ezrin Is Involved in the Formation of the Immunological Synapse and in T Cell Activation

2001 • 189 citations

Identification and functional analysis of the ezrin-binding site in the hyaluronan receptor, CD44

1998 • 188 citations

CD43 Interacts With Moesin and Ezrin and Regulates Its Redistribution to the Uropods of T Lymphocytes at the Cell-Cell Contacts

1998 • 188 citations

RhoA-Dependent Phosphorylation and Relocalization of ERM Proteins into Apical Membrane/Actin Protrusions in Fibroblasts

1998 • 183 citations

Immunofluorescence detection of ezrin/radixin/moesin (ERM) proteins with their carboxyl-terminal threonine phosphorylated in cultured cells and tissues Application of a novel fixation protocol using trichloroacetic acid (TCA) as a fixative

1999 • 175 citations

The protein-tyrosine kinase substrate, p81, is homologous to a chicken microvillar core protein.

1986 • 173 citations

Merlin differentially associates with the microtubule and actin cytoskeleton

1998 • 171 citations

Normal Development of Mice and Unimpaired Cell Adhesion/Cell Motility/Actin-based Cytoskeleton without Compensatory Up-regulation of Ezrin or Radixin in Moesin Gene Knockout

1999 • 170 citations

Moesin, ezrin, and p205 are actin-binding proteins associated with neutrophil plasma membranes.

1995 • 169 citations

Radixin is a novel member of the band 4.1 family.

1991 • 167 citations

The Neurofibromatosis-2 homologue, Merlin, and the tumor suppressor expanded function together in Drosophila to regulate cell proliferation and differentiation

2000 • 161 citations

Neurofibromatosis 2 tumour suppressor schwannomin interacts with βII-spectrin

1998 • 155 citations

Identification of a Novel Member of the Chloride Intracellular Channel Gene Family (CLIC5) That Associates with the Actin Cytoskeleton of Placental Microvilli

2000 • 155 citations

Distinct cellular and subcellular patterns of expression imply distinct functions for the Drosophila homologues of moesin and the neurofibromatosis 2 tumor suppressor, merlin.

1996 • 153 citations

C-Terminal Threonine Phosphorylation Activates ERM Proteins to Link the Cell's Cortical Lipid Bilayer to the Cytoskeleton

1998 • 147 citations

Regulation of F-Actin Binding to Platelet Moesin In Vitro by Both Phosphorylation of Threonine 558 and Polyphosphatidylinositides

1999 • 145 citations

Structural Analysis of Drosophila Merlin Reveals Functional Domains Important for Growth Control and Subcellular Localization

1998 • 144 citations

Characterization of Human Palladin, a Microfilament-associated Protein

2001 • 144 citations

Schwann cell hyperplasia and tumors in transgenic mice expressing a naturally occurring mutant NF2 protein

1999 • 139 citations

Unexpected Effects of FERM Domain Mutations on Catalytic Activity of Jak3

2001 • 139 citations

Ezrin NH2-terminal domain inhibits the cell extension activity of the COOH-terminal domain.

1995 • 135 citations

Regulation of the Neurofibromatosis Type 2 Tumor Suppressor Protein, Merlin, by Adhesion and Growth Arrest Stimuli

1998 • 130 citations

A heparin-binding protein involved in inhibition of smooth-muscle cell proliferation

1988 • 127 citations

Interaction of radixin with Rho small G protein GDP/GTP exchange protein Dbl

1998 • 120 citations

Ezrin Interacts with Focal Adhesion Kinase and Induces Its Activation Independently of Cell-matrix Adhesion

2001 • 120 citations

Ezrin function is required for ROCK-mediated fibroblast transformation by the Net and Dbl oncogenes

2000 • 116 citations

Ezrin links syndecan-2 to the cytoskeleton

2000 • 116 citations

Structural Basis for Neurofibromatosis Type 2

2002 • 115 citations

Signal complex regulation of renal transport proteins: NHERF and regulation of NHE3 by PKA

2000 • 114 citations

A Dual Involvement of the Amino-terminal Domain of Ezrin in F- and G-actin Binding

1997 • 112 citations

Homotypic and heterotypic interaction of the neurofibromatosis 2 tumor suppressor protein merlin and the ERM protein ezrin

1999 • 108 citations

Heterotypic and homotypic associations between ezrin and moesin, two putative membrane-cytoskeletal linking proteins.

1993 • 107 citations

Molecular dissection of radixin: distinct and interdependent functions of the amino- and carboxy-terminal domains.

1995 • 106 citations

The Cytoplasmic Tail of L-selectin Interacts with Members of the Ezrin-Radixin-Moesin (ERM) Family of Proteins

2002 • 103 citations

Hierarchy of Merlin and Ezrin N- and C-terminal Domain Interactions in Homo- and Heterotypic Associations and Their Relationship to Binding of Scaffolding Proteins EBP50 and E3KARP

2001 • 102 citations

Merlin: the neurofibromatosis 2 tumor suppressor

1999 • 101 citations

Janus Kinases and Focal Adhesion Kinases Play in the 4.1 Band: A Superfamily of Band 4.1 Domains Important for Cell Structure and Signal Transduction

1998 • 95 citations

Interdomain Interactions of Radixin in Vitro

1995 • 93 citations

Interdomain Interaction of Merlin Isoforms and Its Influence on Intermolecular Binding to NHE-RF

1999 • 89 citations

Soluble ezrin purified from placenta exists as stable monomers and elongated dimers with masked C-terminal ezrin-radixin-moesin association domains

1995 • 87 citations

Expression level, subcellular distribution and Rho-GDI binding affinity of merlin in comparison with ezrin/radixin/moesin proteins

1999 • 86 citations

The 2.7 Å Crystal Structure of the Activated FERM Domain of Moesin: An Analysis of Structural Changes on Activation^,

2001 • 86 citations

Isolation of Mutations in the Drosophila Homologues of the Human Neurofibromatosis 2 and Yeast CDC42 Genes Using a Simple and Efficient Reverse-Genetic Method

1997 • 85 citations

The neurofibromatosis 2 protein product merlin selectively binds F-actin but not G-actin, and stabilizes the filaments through a lateral association

2001 • 84 citations

Actin Activates a Cryptic Dimerization Potential of the Vinculin Tail Domain

2000 • 81 citations

Identification of Epi64, a Tbc/Rabgap Domain–Containing Microvillar Protein That Binds to the First PDZ Domain of Ebp50 and E3karp

2001 • 80 citations

Microvillus-specific Mr 75,000 plasma membrane protein of human choriocarcinoma cells.

1987 • 80 citations

Ezrin, radixin, and moesin are components of Schwann cell microvilli

2001 • 79 citations

Rho regulates association of both the ERM family and vinculin with the plasma membrane in MDCK cells

1997 • 75 citations

Radixin Is a Component of Hepatocyte Microvilli in Situ

1994 • 74 citations

Normal membrane localization and actin association of the NF2 tumor suppressor protein are dependent on folding of its N-terminal domain

2001 • 74 citations

Functional Analysis of the Neurofibromatosis Type 2 Protein by Means of Disease-Causing Point Mutations

2000 • 64 citations

Errata

1993 • 63 citations

Three determinants in ezrin are responsible for cell extension activity.

1997 • 63 citations

Neurofibromatosis 2: loss of merlin's protective spell

1996 • 62 citations

Interaction between two isoforms of the NF2 tumor suppressor protein, merlin, and between merlin and ezrin, suggests modulation of ERM proteins by merlin

2000 • 60 citations

The Properties of the Protein Tyrosine Phosphatase PTPMEG

1996 • 54 citations

The structure of the FERM domain of merlin, the neurofibromatosis type 2 gene product

2002 • 53 citations

The NF2 interactor, hepatocyte growth factor-regulated tyrosine kinase substrate (HRS), associates with merlin in the 'open' conformation and suppresses cell growth and motility

2001 • 52 citations

FERMing Up the Synapse

2001 • 48 citations

The neurofibromatosis 2 protein product merlin selectively binds F-actin but not G-actin, and stabilizes the filaments through a lateral association

2001 • 46 citations

Polarity and developmental regulation of two PDZ proteins in the retinal pigment epithelium.

2001 • 44 citations

Ezrin binding domain-deficient NHERF attenuates cAMP-mediated inhibition of Na⁺/H⁺exchange in OK cells

2001 • 42 citations

Structural conversion between open and closed forms of radixin: low-angle shadowing electron microscopy 1 1Edited by M. Moody

2001 • 36 citations

Identification of a 55-kDa Ezrin-Related Protein That Induces Cytoskeletal Changes and Localizes to the Nucleolus

1999 • 28 citations

A Systematic Screen for Dominant Second-Site Modifiers of Merlin/NF2 Phenotypes Reveals an Interaction With blistered/DSRF and scribbler

2001 • 24 citations

New functions for the NHERF family of proteins

2001 • 22 citations

The Na-H exchanger regulatory factor.

1998 • 20 citations

Comparative analysis of the Band 4.1/ezrin-related protein tyrosine phosphatase Pez from two Drosophila species: implications for structure and function

2001 • 9 citations