Inhibition of Experimental Liver Cirrhosis in Mice by Telomerase Gene Delivery

Telomeres shorten during ageing of human fibroblasts

1990 • 5,530 citations

Extension of Life-Span by Introduction of Telomerase into Normal Human Cells

1998 • 4,845 citations

A simplified system for generating recombinant adenoviruses

1998 • 3,179 citations

Creation of human tumour cells with defined genetic elements

1999 • 2,333 citations

Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA

1997 • 2,086 citations

TRF2 Protects Human Telomeres from End-to-End Fusions

1998 • 1,679 citations

THE STABILITY OF BROKEN ENDS OF CHROMOSOMES IN ZEA MAYS

1941 • 1,586 citations

The Cellular Basis of Hepatic Fibrosis -- Mechanisms and Treatment Strategies

1993 • 1,444 citations

Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice

1999 • 1,326 citations

Essential role of mouse telomerase in highly proliferative organs

1998 • 1,256 citations

Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells

1998 • 1,206 citations

Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span

1998 • 1,001 citations

p53 Deficiency Rescues the Adverse Effects of Telomere Loss and Cooperates with Telomere Dysfunction to Accelerate Carcinogenesis

1999 • 969 citations

Developmental and tissue-specific regulation of mouse telomerase and telomere length.

1995 • 686 citations

Telomere length dynamics in human lymphocyte subpopulations measured by flow cytometry

1998 • 561 citations

Telomerase, Cell Immortality, and Cancer

1994 • 405 citations

Evidence for a Critical Telomere Length in Senescent Human Fibroblasts

1995 • 391 citations

Complete hepatic regeneration after somatic deletion of an albumin-plasminogen activator transgene

1991 • 387 citations

Short Dysfunctional Telomeres Impair Tumorigenesis in the INK4aΔ2/3 Cancer-Prone Mouse

1999 • 373 citations

Book Review Ethical Problems in Dialysis and Transplantation (Developments in Nephrology. Vol. 33.) Edited by Carl M. Kjellstrand and John B. Dossetor. 235 pp., illustrated. Boston, Kluwer Academic, 1992. $108.50. 0-7923-1625-8

1993 • 329 citations

Is Cirrhosis of the Liver Experimentally Produced by Cc14 An Adequate Model of Human Cirrhosis?

1983 • 320 citations

Telomerase activity in human liver tissues: comparison between chronic liver disease and hepatocellular carcinomas.

1995 • 313 citations

Activation of telomerase in a human tumor.

1994 • 289 citations

Progressive Telomere Shortening in Aplastic Anemia

1998 • 271 citations

Transforming growth factors beta 1 and beta 2 are differentially expressed in fibrotic liver disease.

1991 • 266 citations

The morphology of cirrhosis: definition, nomenclature, and classification.

1977 • 243 citations

Regulation of signal transduction during liver regeneration

1996 • 228 citations

Neonatal bleeding in transgenic mice expressing urokinase-type plasminogen activator

1990 • 223 citations

Transforming growth factor—beta 1 (TGF-β1) and TGF-β1 receptors in normal, cirrhotic, and neoplastic human livers

1995 • 219 citations

Block in Anaphase Chromosome Separation Caused by a Telomerase Template Mutation

1997 • 204 citations

Pathogenesis of Liver Fibrosis

1997 • 176 citations

Progressive telomere shortening and telomerase reactivation during hepatocellular carcinogenesis

1997 • 174 citations

Telomerase activity and telomere length in hepatocellular carcinoma and chronic liver disease

1997 • 160 citations

Severe growth defect in mouse cells lacking the telomerase RNA component

1998 • 159 citations

Telomere Shortening in Chronic Liver Diseases

1995 • 142 citations

Telomerase in human development and cancer

1997 • 139 citations

The roles of telomeres and telomerase in cell life span

1996 • 137 citations

Telomere shortening associated with disease evolution patterns in myelodysplastic syndromes.

1994 • 130 citations

Role of transforming growth factor ? type II receptor in hepatic fibrosis: Studies of human chronic hepatitis C and experimental fibrosis in rats

1999 • 107 citations

Telomere stability is frequently impaired in high-risk groups of patients with myelodysplastic syndromes.

1999 • 99 citations

Telomere length in human liver diseases

1996 • 85 citations

Differential regulation of extracellular matrix synthesis during liver regeneration after partial hepatectomy in rats

1999 • 83 citations

Relationship between hepatocyte proliferative activity and liver functional reserve in human cirrhosis

1996 • 76 citations

Immunosenescence in HIV Pathogenesis

1997 • 73 citations

Relationship between hepatocyte proliferative activity and liver functional reserve in human cirrhosis

1996 • 72 citations

Changes in Telomerase Activity and Telomere Length during Human T Lymphocyte Senescence

1997 • 67 citations

Organ variation in the mutagenicity of MeIQ in Big Blue® lacI transgenic mice

1996 • 55 citations

Quantitation of telomerase activity in hepatocellular carcinoma: A possible aid for a prediction of recurrent diseases in the remnant liver

1998 • 51 citations

Effects of TGF‐βs in the Liver: Cell Proliferation and Fibrogenesis

2007 • 40 citations

The telomere and telomerase: how Do they interact?

2000 • 37 citations

Factors in recent reductions in liver cirrhosis deaths.

1991 • 35 citations

Liver cirrhosis

1998 • 34 citations

Chromosomal Instability and Telomere Length Variations during the Life Span of Human Fibroblast Clones

1997 • 31 citations

Changes in liver cirrhosis death rates in different countries in relation to per capita alcohol consumption and Alcoholics Anonymous membership.

1998 • 28 citations

Telomerase activity and telomere length in human hepatocellular carcinoma

1998 • 28 citations

Telomerase is strongly activated in hepatocellular carcinoma but not in chronic hepatitis and cirrhosis

1998 • 27 citations

Increased CD4⁺ T‐Lymphocyte Senescence Fraction in Advanced Human Immunodeficiency Virus Type 1 Infection

1999 • 26 citations

DOES INCREASED SPENDING ON ALCOHOLISM TREATMENT LEAD TO LOWER CIRRHOSIS DEATH RATES?

1996 • 17 citations

[Telomere length and telomerase activity in hepatocellular carcinoma].

1998 • 4 citations