Chromosomal instability, telomere shortening, and inactivation of p21WAF1/CIP1 in dysplastic nodules of hepatitis B virus-associated multistep hepatocarcinogenesis

Estimating the world cancer burden: Globocan 2000

2001 • 3,781 citations

Primary carcinoma of the liver.A study of 100 cases among 48,900 necropsies

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DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

2005 • 2,633 citations

A DNA damage checkpoint response in telomere-initiated senescence

2003 • 2,600 citations

BRAFE600-associated senescence-like cell cycle arrest of human naevi

2005 • 2,054 citations

Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets

2006 • 1,129 citations

Terminology of nodular hepatocellular lesions

1995 • 1,105 citations

The production of micronuclei from chromosome aberrations in irradiated cultures of human lymphocytes

1976 • 816 citations

Bypass of Senescence After Disruption of p21 ^CIP1/WAF1 Gene in Normal Diploid Human Fibroblasts

1997 • 797 citations

The HUman MicroNucleus Project—An international collaborative study on the use of the micronucleus technique for measuring DNA damage in humans

1999 • 609 citations

DNA damage and repair in telomeres: relation to aging.

1995 • 326 citations

Balancing instability: dual roles for telomerase and telomere dysfunction in tumorigenesis

2002 • 240 citations

Impact of large regenerative, low grade and high grade dysplastic nodules in hepatocellular carcinoma development

2003 • 194 citations

Telomeres and chromosome instability

2006 • 172 citations

Up-Regulation of Telomere-Binding Proteins, TRF1, TRF2, and TIN2 Is Related to Telomere Shortening during Human Multistep Hepatocarcinogenesis

2005 • 145 citations

Dysplastic nodules frequently develop into hepatocellular carcinoma in patients with chronic viral hepatitis and cirrhosis

2005 • 142 citations

Telomere shortening and inactivation of cell cycle checkpoints characterize human hepatocarcinogenesis

2007 • 142 citations

Hepatic Precancerous Lesions and Small Hepatocellular Carcinoma

2007 • 125 citations

Dysplastic nodules and hepatocarcinogenesis

2002 • 104 citations

Induction of aneuploidy by increasing chromosomal instability during dedifferentiation of hepatocellular carcinoma

2004 • 99 citations

Molecular Changes in Hepatocellular Dysplastic Nodules on Microdissected Liver Biopsies

2000 • 81 citations

Telomere Crisis, the Driving Force in Cancer Cell Evolution

1997 • 70 citations

Telomere shortening and telomerase reactivation in dysplastic nodules of human hepatocarcinogenesis

2003 • 70 citations

Chromosomal instability and human hepatocarcinogenesis.

2003 • 67 citations

An early lesion in hepatic carcinogenesis: Loss of heterozygosity in human cirrhotic livers and dysplastic nodules at the 1p36-p34 region

2001 • 66 citations

In vivo micronucleus test using mouse hepatocytes

1989 • 66 citations

Chromosomal Alterations in Hepatocellular Nodules by Comparative Genomic Hybridization: High-Grade Dysplastic Nodules Represent Early Stages of Hepatocellular Carcinoma

2002 • 62 citations

Increased chromosomal alterations and micronuclei formation in human hepatoma HepG2 cells transfected with the hepatitis B virus HBX gene

2002 • 50 citations

Hepatitis B Virus–Associated Multistep Hepatocarcinogenesis: A Stepwise Increase in Allelic Alterations

2008 • 40 citations

Detection of micronuclei formation and nuclear anomalies in regenerative nodules of human cirrhotic livers and relationship to hepatocellular carcinoma

2004 • 33 citations

Quantitative Assessment of hTERT mRNA Expression in Dysplastic Nodules of HBV-Related Hepatocarcinogenesis

2006 • 30 citations

Frequency and DNA content of micronuclei in rat parenchymal liver cells during experimental hepatocarcinogenesis

1993 • 21 citations