Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a

1997 • 4,870 citations

In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2

2004 • 4,416 citations

BRAFE600-associated senescence-like cell cycle arrest of human naevi

2005 • 2,054 citations

The p53 pathway: positive and negative feedback loops

2005 • 1,899 citations

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

2005 • 1,893 citations

Restoration of p53 function leads to tumour regression in vivo

2007 • 1,723 citations

Senescent fibroblasts promote epithelial cell growth and tumorigenesis: A link between cancer and aging

2001 • 1,584 citations

Senescence in premalignant tumours

2005 • 1,394 citations

Intrinsic tumour suppression

2004 • 1,267 citations

Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice.

1995 • 1,223 citations

Oncogene-induced senescence as an initial barrier in lymphoma development

2005 • 1,153 citations

IKKβ Couples Hepatocyte Death to Cytokine-Driven Compensatory Proliferation that Promotes Chemical Hepatocarcinogenesis

2005 • 1,125 citations

Identification and Validation of Oncogenes in Liver Cancer Using an Integrative Oncogenomic Approach

2006 • 1,044 citations

Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound

2002 • 1,025 citations

Principles of Tumor Suppression

2004 • 1,017 citations

Essential role for oncogenic Ras in tumour maintenance

1999 • 880 citations

Microarray analysis of replicative senescence

1999 • 741 citations

Sustained Loss of a Neoplastic Phenotype by Brief Inactivation of MYC

2002 • 639 citations

Second-generation shRNA libraries covering the mouse and human genomes

2005 • 616 citations

Tumor cell senescence in cancer treatment.

2003 • 598 citations

Probing tumor phenotypes using stable and regulated synthetic microRNA precursors

2005 • 522 citations

The pathological response to DNA damage does not contribute to p53-mediated tumour suppression

2006 • 380 citations

Cellular senescence in naevi and immortalisation in melanoma: a role for p16?

2006 • 375 citations

The role of regulatory T cells in the control of natural killer cells: relevance during tumor progression

2006 • 260 citations

TP53 and liver carcinogenesis

2003 • 242 citations

Ras Induces Vascular Smooth Muscle Cell Senescence and Inflammation in Human Atherosclerosis

2003 • 197 citations

Beta-glucan functions as an adjuvant for monoclonal antibody immunotherapy by recruiting tumoricidal granulocytes as killer cells.

2003 • 167 citations

Involvement of TRAIL and its receptors in viral hepatitis

2002 • 145 citations

p53-Dependent ICAM-1 overexpression in senescent human cells identified in atherosclerotic lesions

2005 • 105 citations

Generation and Analysis of Genetically Defined Liver Carcinomas Derived from Bipotential Liver Progenitors

2005 • 61 citations