Telomerase does not counteract telomere shortening but protects mitochondrial function under oxidative stress

A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

1995 • 6,950 citations

Extension of Life-Span by Introduction of Telomerase into Normal Human Cells

1998 • 4,845 citations

Mitochondria, Oxidants, and Aging

2005 • 4,115 citations

A survey of telomerase activity in human cancer

1997 • 2,747 citations

A DNA damage checkpoint response in telomere-initiated senescence

2003 • 2,600 citations

Oxidative stress shortens telomeres

2002 • 2,362 citations

Mitochondrial Signaling

2004 • 831 citations

Mitochondrial Dysfunction Accounts for the Stochastic Heterogeneity in Telomere-Dependent Senescence

2007 • 696 citations

Accumulation of single-strand breaks is the major cause of telomere shortening in human fibroblasts

2000 • 532 citations

Chronic oxidative stress compromises telomere integrity and accelerates the onset of senescence in human endothelial cells

2004 • 484 citations

Telomerase modulates expression of growth-controlling genes and enhances cell proliferation

2003 • 435 citations

Telomerase contributes to tumorigenesis by a telomere length-independent mechanism

2002 • 427 citations

Conditional telomerase induction causes proliferation of hair follicle stem cells

2005 • 418 citations

Preferential Accumulation of Single-Stranded Regions in Telomeres of Human Fibroblasts

1998 • 414 citations

Human cell senescence as a DNA damage response

2004 • 403 citations

Quantitative PCR-Based Measurement of Nuclear and Mitochondrial DNA Damage and Repair in Mammalian Cells

2014 • 372 citations

Antioxidants Inhibit Nuclear Export of Telomerase Reverse Transcriptase and Delay Replicative Senescence of Endothelial Cells

2004 • 370 citations

Telomerase reverse transcriptase promotes cardiac muscle cell proliferation, hypertrophy, and survival

2001 • 285 citations

Quantitative PCR-Based Measurement of Nuclear and Mitochondrial DNA Damage and Repair in Mammalian Cells

2008 • 271 citations

Hydrogen Peroxide Triggers Nuclear Export of Telomerase Reverse Transcriptase via Src Kinase Family-Dependent Phosphorylation of Tyrosine 707

2003 • 256 citations

hTERT associates with human telomeres and enhances genomic stability and DNA repair

2003 • 242 citations

Mitochondrial hTERT exacerbates free‐radical‐mediated mtDNA damage

2004 • 241 citations

Age-dependent telomere shortening is slowed down by enrichment of intracellular vitamin C via suppression of oxidative stress

1998 • 237 citations

Cutting Edge: Telomerase Activation in Human T Lymphocytes Does Not Require Increase in Telomerase Reverse Transcriptase (hTERT) Protein But Is Associated with hTERT Phosphorylation and Nuclear Translocation

2001 • 235 citations

Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.

2005 • 204 citations

Mitochondrial localization of telomerase as a determinant for hydrogen peroxide-induced mitochondrial DNA damage and apoptosis

2006 • 192 citations

The Catalytic Subunit of Telomerase Is Expressed in Developing Brain Neurons and Serves a Cell Survival-Promoting Function

2000 • 189 citations

The Catalytic Subunit of Telomerase Protects Neurons Against Amyloid β‐Peptide‐Induced Apoptosis

2000 • 174 citations

Cellular and Gene Expression Responses Involved in the Rapid Growth Inhibition of Human Cancer Cells by RNA Interference-mediated Depletion of Telomerase RNA

2005 • 156 citations

Inhibition of telomerase increases the susceptibility of human malignant glioblastoma cells to cisplatin-induced apoptosis

1998 • 155 citations

Overexpression of Telomerase Confers Growth Advantage, Stress Resistance, and Enhanced Differentiation of ESCs Toward the Hematopoietic Lineage

2005 • 147 citations

Mitochondria-to-nucleus stress signaling in mammalian cells: Nature of nuclear gene targets, transcription regulation, and induced resistance to apoptosis

2005 • 144 citations

hTERT: a novel endogenous inhibitor of the mitochondrial cell death pathway

2006 • 143 citations

Stochastic Variation in Telomere Shortening Rate Causes Heterogeneity of Human Fibroblast Replicative Life Span

2004 • 135 citations

Ectopic Expression of the Catalytic Subunit of Telomerase Protects against Brain Injury Resulting from Ischemia and NMDA-Induced Neurotoxicity

2004 • 134 citations

Involvement of hTERT in apoptosis induced by interference with Bcl-2 expression and function

2005 • 132 citations

Genes and pathways downstream of telomerase in melanoma metastasis

2006 • 126 citations

Immunodetection of human telomerase reverse-transcriptase (hTERT) re-appraised: nucleolin and telomerase cross paths

2006 • 120 citations

Ribozyme cleavage of telomerase mRNA sensitizes breast epithelial cells to inhibitors of topoisomerase.

2001 • 117 citations

Telomere dysfunction alters the chemotherapeutic profile of transformed cells

2001 • 112 citations

The genome-wide expression response to telomerase deletion in Saccharomyces cerevisiae

2002 • 98 citations

TERT suppresses apoptotis at a premitochondrial step by a mechanism requiring reverse transcriptase activity and 14‐3‐3 protein binding ability

2003 • 94 citations

Telomerase inhibition by siRNA causes senescence and apoptosis in Barrett's adenocarcinoma cells: mechanism and therapeutic potential

2005 • 93 citations

DNA supercoiling suppresses real-time PCR: a new approach to the quantification of mitochondrial DNA damage and repair

2007 • 92 citations

The retrograde response links metabolism with stress responses, chromatin-dependent gene activation, and genome stability in yeast aging

2005 • 89 citations

Death receptor signaling regulatory function for telomerase: hTERT abolishes TRAIL-induced apoptosis, independently of telomere maintenance

2004 • 78 citations

Expression of mTert in primary murine cells links the growth-promoting effects of telomerase to transforming growth factor-β signaling

2006 • 71 citations

DNA base excision repair activities and pathway function in mitochondrial and cellular lysates from cells lacking mitochondrial DNA

2004 • 56 citations

Cross-talk between Bcr-Abl tyrosine kinase, protein kinase C and telomerase—a potential reason for resistance to Glivec in chronic myelogenous leukaemia

2003 • 25 citations

Telomere dysfunction results in enhanced organismal sensitivity to the alkylating agent N-methyl-N-nitrosourea.

2003 • 23 citations

Effectors of mammalian telomere dysfunction: a comparative transcriptome analysis using mouse models

2005 • 14 citations