Polypyrimidine tracts and their binding proteins: Regulatory sites for posttranscriptional modulation of gene expression

A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation

1986 • 4,200 citations

Identification of a common nucleotide sequence in the 3'-untranslated region of mRNA molecules specifying inflammatory mediators.

1986 • 1,591 citations

Splicing of Messenger RNA Precursors

1987 • 919 citations

Regulation of Lymphokine Messenger RNA Stability by a Surface-Mediated T Cell Activation Pathway

1989 • 910 citations

Structure of E. coli Glutaminyl-tRNA Synthetase Complexed with tRNA ^Gln and ATP at 2.8 Å Resolution

1989 • 888 citations

TRANSCRIPTION TERMINATION AND THE REGULATION OF GENE EXPRESSION

1986 • 811 citations

Arginine-Mediated RNA Recognition: the Arginine Fork

1991 • 757 citations

ALTERNATIVE SPLICING IN THE CONTROL OF GENE EXPRESSION

1989 • 701 citations

RNA-binding proteins as developmental regulators.

1989 • 679 citations

Crystal structure of the RNA-binding domain of the U1 small nuclear ribonucleoprotein A

1990 • 622 citations

Cloning and domain structure of the mammalian splicing factor U2AF

1992 • 566 citations

Internal initiation of translation mediated by the 5′ leader of a cellular mRNA

1991 • 554 citations

Two distinct destabilizing elements in the c-fos message trigger deadenylation as a first step in rapid mRNA decay.

1991 • 546 citations

Stepwise assembly of a pre-mRNA splicing complex requires U-snRNPs and specific intron sequences

1985 • 524 citations

Nucleotide sequences in Xenopus 5S DNA required for transcription termination

1981 • 515 citations

Identification of an AUUUA-Specific Messenger RNA Binding Protein

1989 • 515 citations

An A + U-rich element RNA-binding factor regulates c-myc mRNA stability in vitro.

1991 • 484 citations

Cap-independent translation of encephalomyocarditis virus RNA: structural elements of the internal ribosomal entry site and involvement of a cellular 57-kD RNA-binding protein.

1990 • 428 citations

Poly(A) elongation during Xenopus oocyte maturation is required for translational recruitment and is mediated by a short sequence element.

1989 • 412 citations

Intron sequences involved in lariat formation during pre-mRNA splicing

1985 • 402 citations

Ro small cytoplasmic ribonucleoproteins are a subclass of La ribonucleoproteins: further characterization of the Ro and La small ribonucleoproteins from uninfected mammalian cells.

1981 • 384 citations

Identification, purification, and biochemical characterization of U2 small nuclear ribonucleoprotein auxiliary factor.

1989 • 375 citations

Precursor molecules of both human 5S ribosomal RNA and transfer RNAs are bound by a cellular protein reactive with anti-La Lupus antibodies

1982 • 363 citations

Identification and purification of a 62,000-dalton protein that binds specifically to the polypyrimidine tract of introns.

1989 • 349 citations

Oligopyrimidine tract at the 5' end of mammalian ribosomal protein mRNAs is required for their translational control.

1991 • 342 citations

Function of the mammalian La protein: evidence for its action in transcription termination by RNA polymerase III.

1989 • 340 citations

Characterization and molecular cloning of polypyrimidine tract-binding protein: a component of a complex necessary for pre-mRNA splicing.

1991 • 338 citations

Binding of the Drosophila Sex-lethal gene product to the alternative splice site of transformer primary transcript

1990 • 333 citations

Control of doublesex Alternative Splicing by transformer and transformer-2 in Drosophila

1991 • 333 citations

Poly(A) addition during maturation of frog oocytes: distinct nuclear and cytoplasmic activities and regulation by the sequence UUUUUAU.

1989 • 332 citations

The organization of 3' splice-site sequences in mammalian introns.

1989 • 310 citations

hnRNP 1, the polyprimidine tract-binding protein: distinct nuclear localization and association with hnRNAs

1992 • 299 citations

An inducible cytoplasmic factor (AU-B) binds selectively to AUUUA multimers in the 3' untranslated region of lymphokine mRNA.

1991 • 293 citations

Oligonucleotide sequence signaling transcriptional termination of vaccinia virus early genes.

1987 • 280 citations

REGULATED mRNA STABILITY

1990 • 279 citations

An ordered pathway of snRNP binding during mammalian pre-mRNA splicing complex assembly.

1987 • 272 citations

A cellular protein that binds to the 5'-noncoding region of poliovirus RNA: implications for internal translation initiation.

1989 • 271 citations

A 32-kilodalton protein binds to AU-rich domains in the 3' untranslated regions of rapidly degraded mRNAs.

1991 • 268 citations

Cap-Binding Proteins of Eukaryotic Messenger RNA: Functions in Initiation and Control of Translation

1988 • 266 citations

Characterization of cDNAs encoding the polypyrimidine tract-binding protein.

1991 • 257 citations

Cap recognition and the entry of mRNA into the protein synthesis initiation cycle

1988 • 256 citations

Biochemical characterization of U2 snRNP auxiliary factor: an essential pre-mRNA splicing factor with a novel intranuclear distribution.

1991 • 255 citations

In vitro translation of poliovirus RNA: utilization of internal initiation sites in reticulocyte lysate

1984 • 239 citations

Transient translational silencing by reversible mRNA deadenylation

1992 • 239 citations

Affinity Chromatography of Splicing Complexes: U2, U5, and U4 + U6 Small Nuclear Ribonucleoprotein Particles in the Spliceosome

1986 • 238 citations

Human Gene Encoding the 78,000-Dalton Glucose-Regulated Protein and Its Pseudogene: Structure, Conservation, and Regulation

1988 • 236 citations

GM-CSF and oncogene mRNA stabilities are independently regulated in trans in a mouse monocytic tumor

1988 • 227 citations

The adenosine-uridine binding factor recognizes the AU-rich elements of cytokine, lymphokine, and oncogene mRNAs.

1991 • 222 citations

Functional analysis of the internal translation initiation site of foot-and-mouth disease virus

1990 • 202 citations

The RNA binding protein La influences both the accuracy and the efficiency of RNA polymerase III transcription in vitro.

1989 • 202 citations

Positive Control of Pre-mRNA Splicing in Vitro

1992 • 199 citations

Specific binding of a basic peptide from HIV-1 Rev.

1992 • 197 citations

Sequence-specific adenylations and deadenylations accompany changes in the translation of maternal messenger RNA after fertilization of Spisula oocytes

1983 • 190 citations

Structural and functional analysis of the ribosome landing pad of poliovirus type 2: in vivo translation studies

1991 • 185 citations

Nucleotide sequence of a major messenger RNA for a 21 kilodalton polypeptide that is under translational control in mouse tumor cells

1988 • 183 citations

Evidence for instability of mRNAs containing AUUUA motifs mediated through translation-dependent assembly of a > 20S degradation complex.

1992 • 181 citations

Specific and stable intron-factor interactions are established early during in vitro pre-mRNA splicing

1985 • 180 citations

Characterization of the multigene family encoding the mouse S16 ribosomal protein: strategy for distinguishing an expressed gene from its processed pseudogene counterparts by an analysis of total genomic DNA.

1985 • 179 citations

Translation of poliovirus rna in vitro: Changes in cleavage pattern and initiation sites by ribosomal salt wash

1979 • 178 citations

A maternal tail of poly(a): The long and the short of it

1992 • 177 citations

Mechanism of interferon action: Identification of a RNA binding domain within the N-terminal region of the human RNA-dependent P1/eIF-2α protein kinase

1992 • 170 citations

Translational control by cytoplasmic polyadenylation during Xenopus oocyte maturation: characterization of cis and trans elements and regulation by cyclin/MPF.

1990 • 165 citations

Purification and characterization of a transcription termination factor from vaccinia virions.

1987 • 164 citations

Translation of poliovirus RNA: role of an essential cis-acting oligopyrimidine element within the 5' nontranslated region and involvement of a cellular 57-kilodalton protein

1991 • 155 citations

Interaction between VA RNA and the lupus antigen La: formation of a ribonucleoprotein particle in vitro.

1982 • 154 citations

Alpha-tropomyosin mutually exclusive exon selection: competition between branchpoint/polypyrimidine tracts determines default exon choice.

1991 • 146 citations

Glucocorticoids selectively inhibit translation of ribosomal protein mRNAs in P1798 lymphosarcoma cells.

1987 • 145 citations

Maturation-specific polyadenylation: in vitro activation by p34cdc2 and phosphorylation of a 58-kD CPE-binding protein.

1991 • 144 citations

Maturation-specific polyadenylation and translational control: diversity of cytoplasmic polyadenylation elements, influence of poly(A) tail size, and formation of stable polyadenylation complexes.

1990 • 144 citations

Transcription of vaccinia virus early genes by enzymes isolated from vaccinia virions terminates downstream of a regulatory sequence

1986 • 139 citations

Interaction of a cellular 57-kilodalton protein with the internal translation initiation site of foot-and-mouth disease virus

1991 • 135 citations

U-rich sequence-binding proteins (URBPs) interacting with a 20-nucleotide U-rich sequence in the 3' untranslated region of c-fos mRNA may be involved in the first step of c-fos mRNA degradation.

1992 • 135 citations

Translation of glucose-regulated protein 78/immunoglobulin heavy-chain binding protein mRNA is increased in poliovirus-infected cells at a time when cap-dependent translation of cellular mRNAs is inhibited.

1989 • 134 citations

Point mutations modify the response of poliovirus RNA to a translation initiation factor: A comparison of neurovirulent and attenuated strains

1988 • 128 citations

RNA polymerase: regulation of transcript elongation and termination

1991 • 127 citations

Simultaneous cytoplasmic redistribution of ribosomal protein L32 mRNA and phosphorylation of eukaryotic initiation factor 4E after mitogenic stimulation of Swiss 3T3 cells.

1990 • 120 citations

A U-rich tract enhances usage of an alternative 3′ splice site in yeast

1991 • 119 citations

La Antigen Recognizes and Binds to the 3′-Oligouridylate Tail of a Small RNA

1984 • 115 citations

Transcriptional and translational regulation of ribosomal protein formation during mouse myoblast differentiation.

1987 • 114 citations

The spliceosome assembly pathway in mammalian extracts.

1992 • 111 citations

The War Against the Interferon-induced dsRNA-Activated Protein Kinase: Can Viruses Win?

1992 • 105 citations

The role of the polypyrimidine stretch at the SV40 early pre-mRNA 3′ splice site in alternative splicing.

1988 • 105 citations

In vitro mutational analysis of cis-acting RNA translational elements within the poliovirus type 2 5' untranslated region

1991 • 103 citations

A regulatory cis element and a specific binding factor involved in the mitogenic control of murine ribosomal protein L32 translation.

1992 • 94 citations

Cooperation of Pre-mRNA Sequence Elements in Splice Site Selection

1992 • 90 citations

A Freeze-Frame View of Eukaryotic Transcription During Elongation and Capping of Nascent mRNA

1992 • 89 citations

The 5' untranslated region of mRNA for ribosomal protein S19 is involved in its translational regulation during Xenopus development.

1990 • 86 citations

Factor-dependent transcription termination by vaccinia virus RNA polymerase. Evidence that the cis-acting termination signal is in nascent RNA.

1988 • 84 citations

Expression of ribosomal protein genes and regulation of ribosome biosynthesis in Xenopus development

1989 • 80 citations

Ribosomal proteins are synthesized preferentially in cells commencing growth

1982 • 74 citations

RNA-protein interactions

1991 • 71 citations

Preferential stimulation of ribosomal protein synthesis by insulin and in the absence of ribosomal and messenger ribonucleic acid formation

1980 • 71 citations

Nuclear RNA-binding Proteins

1991 • 69 citations

Cloning and sequencing of PYBP, a pyrimidine-rich specific single strand DNA-binding protein

1991 • 69 citations

Sequences mediating the translation of mouse S16 ribosomal protein mRNA during myoblast differentiation and in vitro and possible control points for the in vitro translation.

1991 • 66 citations

Differential Regulation of Trypsinogen mRNA Translation: Full-Length mRNA Sequences Encoding Two Oppositely Charged Trypsinogen Isoenzymes in the Dog Pancreas

1985 • 63 citations

Specific interactions of HeLa cell proteins with proposed translation domains of the poliovirus 5' noncoding region

1992 • 54 citations

Murine polypyrimidine tract binding protein. Purification, cloning, and mapping of the RNA binding domain.

1991 • 54 citations

Rho-dependent transcription termination

1990 • 48 citations

The rat poly Pyrimidine Tract binding protein (PTB) interacts with a single-stranded DNA motif in a liver-specific enhancer

1992 • 44 citations

Discrete functional stages of vaccinia virus early transcription during a single round of RNA synthesis in vitro

1991 • 42 citations

A 62,000 molecular weight spliceosome protein crosslinks to the intron polypyrimidine tract

1990 • 33 citations

Detection of a cellular polypeptide associated with adenovirus-coded VA RNA using in vitro labeling of proteins cross-linked to RNA

1982 • 31 citations

Effects of decreased cytosine content on rho interaction with the rho-dependent terminator trp t' in Escherichia coli.

1992 • 31 citations

Alterations in the Polypyrimidine Sequence Affect the in vitro Splicing Reactions Catalyzed by HeLa cell-Free Preparations

1989 • 28 citations

Selection of Sequence elements that substitute for the standard AATAAA motif which signals 3′ processing and polyadenylation of late simian virus 40 mRNAs

1985 • 25 citations

A cytosine‐ over guanosine‐rich sequence in RNA activates rho‐dependent transcription termination

1991 • 24 citations

Isolation and sequence of the canine pancreatic phospholipase A2 gene

1990 • 12 citations