REGULATED mRNA STABILITY

A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation

1986 • 4,200 citations

Identification of a common nucleotide sequence in the 3'-untranslated region of mRNA molecules specifying inflammatory mediators.

1986 • 1,591 citations

Induction of c-fos gene and protein by growth factors precedes activation of c-myc

1984 • 1,463 citations

Platelet-derived growth factor induces rapid but transient expression of the c-fos gene and protein

1984 • 949 citations

A unique cap(m7GpppXm)-dependent influenza virion endonuclease cleaves capped RNAs to generate the primers that initiate viral RNA transcription

1981 • 703 citations

Cytoplasmic protein binds in vitro to a highly conserved sequence in the 5' untranslated region of ferritin heavy- and light-subunit mRNAs.

1988 • 684 citations

The c-fos transcript is targeted for rapid decay by two distinct mRNA degradation pathways.

1989 • 601 citations

A stem-loop in the 3′ untranslated region mediates iron-dependent regulation of transferrin receptor mRNA stability in the cytoplasm

1988 • 565 citations

Effect of protein synthesis inhibitors on growth factor activation of c-fos, c-myc, and actin gene transcription.

1986 • 548 citations

A specific mRNA binding factor regulates the iron-dependent stability of cytoplasmic transferrin receptor mRNA

1989 • 511 citations

Enhanced Transcription of c- myc in Bursal Lymphoma Cells Requires Continuous Protein Synthesis

1985 • 469 citations

Regulation of human histone gene expression: kinetics of accumulation and changes in the rate of synthesis and in the half-lives of individual histone mRNAs during the HeLa cell cycle.

1983 • 452 citations

Unpolymerized tubulin modulates the level of tubulin mRNAs

1981 • 392 citations

Oxidation-Reduction and the Molecular Mechanism of a Regulatory RNA-Protein Interaction

1989 • 387 citations

The poly(A)-poly(A)-binding protein complex is a major determinant of mRNA stability in vitro.

1989 • 373 citations

A Protein of Molecular Weight 78,000 Bound to the Polyadenylate Region of Eukaryotic Messenger RNAs

1973 • 347 citations

Autoregulated instability of β-tubulin mRNAs by recognition of the nascent amino terminus of βtubulin

1988 • 345 citations

Cell-cycle regulation of yeast histone mRNA

1981 • 336 citations

Poly(A) shortening and degradation of the 3' A+U-rich sequences of human c-myc mRNA in a cell-free system.

1988 • 324 citations

Normal stoichiometry of histone dimer sets is necessary for high fidelity of mitotic chromosome transmission

1986 • 322 citations

Rapid Cytoplasmic Turnover of c-myc mRNA: Requirement of the 3′ Untranslated Sequences

1987 • 302 citations

Histone mRNA concentrations are regulated at the level of transcription and mRNA degradation.

1983 • 298 citations

Changes in histone gene dosage alter transcription in yeast.

1988 • 275 citations

The Role of the Poly(A) Sequence in Mammalian Messenger RN

1981 • 254 citations

The stem-loop structure at the 3' end of histone mRNA is necessary and sufficient for regulation of histone mRNA stability.

1987 • 238 citations

GM-CSF and oncogene mRNA stabilities are independently regulated in trans in a mouse monocytic tumor

1988 • 227 citations

Posttranscriptional mechanisms are responsible for accumulation of truncated c-myc RNAs in murine plasma cell tumors

1985 • 227 citations

Autoregulation of tubulin expression is achieved through specific degradation of polysomal tubulin mRNAs

1987 • 206 citations

Increased rate of degradation of c-myc mRNA in interferon-treated Daudi cells.

1985 • 203 citations

Multiple regulatory steps control histone mRNA concentrations

1988 • 199 citations

The fos Oncogene

1987 • 196 citations

Consequences of frameshift mutations at the immunoglobulin heavy chain locus of the mouse.

1985 • 193 citations

Globin mRNA Species Containing Poly(A) Segments of Different Lengths

1976 • 183 citations

H4 histone messenger RNA decay in cell-free extracts initiates at or near the 3′ terminus and proceeds 3′ to 5′

1986 • 179 citations

Truncation of exon 1 from the c-myc gene results in prolonged c-myc mRNa stability.

1985 • 172 citations

Regulation of c-myc mRNA Stability In Vitro by a Labile Destabilizer with an Essential Nucleic Acid Component

1989 • 172 citations

Cell cycle regulation of mouse H3 histone mRNA metabolism.

1984 • 165 citations

Periodic transcription of yeast histone genes

1982 • 160 citations

Aberrant c-myc RNAs of Burkitt's lymphoma cells have longer half-lives.

1985 • 152 citations

Further evidence of transcriptional and translational control of histone messenger RNA during the HeLa S3 cycle

1975 • 145 citations

Autoregulated changes in stability of polyribosome-bound beta-tubulin mRNAs are specified by the first 13 translated nucleotides.

1988 • 141 citations

Effect of iron chelators on the transferrin receptor in K562 cells.

1984 • 134 citations

Transcriptional regulation by iron of the gene for the transferrin receptor.

1986 • 131 citations

Is apparent autoregulatory control of tubulin synthesis nontranscriptionally regulated?

1983 • 125 citations

Multiple determinants of eukaryotic mRNA stability.

1989 • 118 citations

Regulation of human histone gene expression: transcriptional and posttranscriptional control in the coupling of histone messenger RNA stability with DNA replication

1987 • 111 citations

An analysis of the rate of metallothionein mRNA POLY(A)-shortening using RNA blot hybridization

1985 • 108 citations

Autoregulation of tubulin synthesis in enucleated cells

1985 • 106 citations

Rapid reversible changes in the rate of histone gene transcription and histone mRNA levels in mouse myeloma cells.

1984 • 100 citations

Histone genes: Not so simple after all

1984 • 97 citations

Regulation of human histone gene expression during the HeLa cell cycle requires protein synthesis.

1984 • 91 citations

Retention of autoregulatory control of tubulin synthesis in cytoplasts: demonstration of a cytoplasmic mechanism that regulates the level of tubulin expression.

1985 • 86 citations

Selective degradation of mRNA: the role of short-lived proteins in differential destabilization of insulin-induced creatine phosphokinase and myosin heavy chain mRNAs during rat skeletal muscle L6 cell differentiation.

1988 • 70 citations

Translational stability of native and deadenylylated rabbit globin mRNA injected into HeLa cells.

1981 • 70 citations

Sequences controlling histone H4 mRNA abundance.

1987 • 68 citations

Removal of an mRNA destabilizing element correlates with the increased oncogenicity of proto-oncogene fos.

1989 • 63 citations

On the Translational Control of Histone Synthesis

1974 • 59 citations

Substrate specificity of the exonuclease activity that degrades H4 histone mRNA.

1987 • 58 citations

Increased histone mRNA levels during inhibition of protein synthesis

1983 • 50 citations

Sequence determinants of c-myc mRNA turn-over: influence of 3' and 5' non-coding regions.

1988 • 37 citations