Alterations in the Polypyrimidine Sequence Affect the in vitro Splicing Reactions Catalyzed by HeLa cell-Free Preparations

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Efficientin vitrosynthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter

1984 • 6,459 citations

Organization and Expression of Eucaryotic Split Genes Coding for Proteins

1981 • 4,730 citations

A catalogue of splice junction sequences

1982 • 3,861 citations

SPLICING OF MESSENGER RNA PRECURSORS

1986 • 1,233 citations

Oligonucleotide-Directed Mutagenesis: A Simple Method Using Two Oligonucleotide Primers and a Single-Stranded DNA Template

1984 • 947 citations

Stepwise assembly of a pre-mRNA splicing complex requires U-snRNPs and specific intron sequences

1985 • 524 citations

Nucleotide sequences from the adenovirus-2 genome.

1982 • 345 citations

A minimal intron length but no specific internal sequence is required for splicing the large rabbit β-globin intron

1984 • 328 citations

The 3′ Splice Site of Pre-Messenger RNA Is Recognized by a Small Nuclear Ribonucleoprotein

1985 • 310 citations

A protein associated with small nuclear ribonucleoprotein particles recognizes the 3′ splice site of premessenger RNA

1986 • 283 citations

A protein that specifically recognizes the 3′ splice site of mammalian pre-mRNA introns is associated with a small nuclear ribonucleoprotein

1986 • 274 citations

A versatile primer for DNA sequencing in the M13mp2 cloning system

1980 • 241 citations

Role of the 3′ splice site consensus sequence in mammalian pre-mRNA splicing

1985 • 184 citations

Presplicing complex formation requires two proteins and U2 snRNP.

1988 • 117 citations

Pre-mRNA splicing by complementation with purified human UI, U2, U4/U6 and U5 snRNPs

1988 • 112 citations

Effect of mutations at the lariat branch acceptor site on β-globin pre-mRNA splicing in vitro

1986 • 111 citations

The role of the polypyrimidine stretch at the SV40 early pre-mRNA 3′ splice site in alternative splicing.

1988 • 105 citations

Alternative RNA Splicing Generates Transcripts Encoding a Thorax-Specific Isoform of Drosophila melanogaster Myosin Heavy Chain

1986 • 103 citations

Developmental variations in the splicing pattern of transcripts from the Drosophila gene encoding myosin alkali light chain result in different carboxyl-terminal amino acid sequences.

1985 • 101 citations

Abnormally spliced messenger RNA in erythroid cells from patients with β+ thalassemia and monkey cells expressing a cloned β+-thalassemic gene

1982 • 91 citations

Differential processing of RNA transcribed from the single-copy Drosophila myosin heavy chain gene produces four mRNAs that encode two polypeptides.

1986 • 76 citations

RNA splicing products formed with isolated fractions from HeLa cells are associated with fast-sedimenting complexes.

1986 • 75 citations

Purification of a RNA debranching activity from HeLa cells.

1987 • 63 citations

Isolation and characterization of two fractions from HeLa cells required for mRNA splicing in vitro.

1985 • 51 citations

mRNA precursor splicing in vivo: sequence requirements determined by deletion analysis of an intervening sequence.

1985 • 36 citations

In vitro formation of a lariat structure containing a G2'-5'G linkage.

1987 • 34 citations