Intravenous infusion of a replication-selective adenovirus (ONYX-015) in cancer patients: safety, feasibility and biological activity

Integrins αvβ3 and αvβ5 promote adenovirus internalization but not virus attachment

1993 • 2,182 citations

Phosphatidylinositol-3-OH kinase direct target of Ras

1994 • 1,923 citations

Liposome mediated depletion of macrophages: mechanism of action, preparation of liposomes and applications

1994 • 1,752 citations

An Adenovirus Mutant That Replicates Selectively in p53- Deficient Human Tumor Cells

1996 • 1,735 citations

Clinical Implications of the p53 Tumor-Suppressor Gene

1993 • 1,341 citations

A controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer

2000 • 1,092 citations

Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses

1995 • 1,048 citations

Experimental Therapy of Human Glioma by Means of a Genetically Engineered Virus Mutant

1991 • 994 citations

ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents

1997 • 945 citations

Administration of an adenovirus containing the human CFTR cDNA to the respiratory tract of individuals with cystic fibrosis

1994 • 829 citations

Stepwise dismantling of adenovirus 2 during entry into cells

1993 • 810 citations

An efficient and flexible system for construction of adenovirus vectors with insertions or deletions in early regions 1 and 3.

1994 • 743 citations

Gene Therapy for Cancer: What Have We Done and Where Are We Going?

1997 • 635 citations

Ablation of E2A in recombinant adenoviruses improves transgene persistence and decreases inflammatory response in mouse liver.

1994 • 627 citations

MHC class I-cestricted cytotoxic T lymphocytes to viral antigens destroy hepatocytes in mice infected with E1-deleted recombinant adenoviruses

1994 • 619 citations

Cellular and humoral immune responses to adenoviral vectors containing factor IX gene: tolerization of factor IX and vector antigens allows for long-term expression.

1995 • 599 citations

Prostate attenuated replication competent adenovirus (ARCA) CN706: a selective cytotoxic for prostate-specific antigen-positive prostate cancer cells.

1997 • 589 citations

Innate Immune Mechanisms Dominate Elimination of Adenoviral Vectors FollowingIn VivoAdministration

1997 • 497 citations

Rho Family GTPases Bind to Phosphoinositide Kinases

1995 • 469 citations

Induction of chemosensitivity in human lung cancer cells in vivo by adenovirus-mediated transfer of the wild-type p53 gene.

1994 • 465 citations

The liposome-mediated macrophage ‘suicide’ technique

1989 • 455 citations

A phase I study of Onyx-015, an E1B attenuated adenovirus, administered intratumorally to patients with recurrent head and neck cancer.

2000 • 426 citations

Adenovirus proteins from both E1B reading frames are required for transformation of rodent cells by viral infection and DNA transfection

1987 • 394 citations

Activation of phosphoinositide 3-kinase activity by Cdc42Hs binding to p85.

1994 • 392 citations

Replication of ONYX-015, a Potential Anticancer Adenovirus, Is Independent of p53 Status in Tumor Cells

1998 • 356 citations

The route of administration is a major determinant of the transduction efficiency of rat tissues by adenoviral recombinants.

1995 • 339 citations

A Novel Three-Pronged Approach to Kill Cancer Cells Selectively: Concomitant Viral, Double Suicide Gene, and Radiotherapy

1998 • 337 citations

Assessment of Recombinant Adenoviral Vectors for Hepatic Gene Therapy

1993 • 310 citations

p53 and DNA polymerase α compete for binding to SV40 T antigen

1987 • 291 citations

Long–term hepatic adenovirus–mediated gene expression in mice following CTLA4Ig administration

1995 • 281 citations

Human papillomavirus E6 proteins bind p53 in vivo and abrogate p53-mediated repression of transcription.

1992 • 272 citations

Depletion and repopulation of macrophages in spleen and liver of rat after intravenous treatment with liposome-encapsulated dichloromethylene diphosphonate

1990 • 269 citations

Upregulation of class I major histocompatibility complex antigens by interferon gamma is necessary for T-cell-mediated elimination of recombinant adenovirus-infected hepatocytes in vivo.

1995 • 258 citations

Elimination of mouse splenic macrophages correlates with increased susceptibility to experimental disseminated candidiasis.

1994 • 251 citations

Adenovirus Endocytosis via α _v Integrins Requires Phosphoinositide-3-OH Kinase

1998 • 249 citations

Region E3 of adenovirus: A cassette of genes involved in host immunosurveillance and virus-cell interactions

1991 • 249 citations

Recombinant IL–12 prevents formation of blocking IgA antibodies to recombinant adenovirus and allows repeated gene therapy to mouse lung

1995 • 246 citations

Strain related variations in adenovirally mediated transgene expression from mouse hepatocytes in vivo: comparisons between immunocompetent and immunodeficient inbred strains.

1995 • 244 citations

Adenovirus Endocytosis Requires Actin Cytoskeleton Reorganization Mediated by Rho Family GTPases

1998 • 244 citations

The impact of developmental stage, route of administration and the immune system on adenovirus-mediated gene transfer.

1994 • 217 citations

Neutralization of adenoviruses: kinetics, stoichiometry, and mechanisms

1988 • 213 citations

Enhancement of in vivo adenovirus-mediated gene transfer and expression by prior depletion of tissue macrophages in the target organ

1997 • 213 citations

Insertion of the adenoviral E3 region into a recombinant viral vector prevents antiviral humoral and cellular immune responses and permits long-term gene expression

1997 • 208 citations

Macrophage Subset Repopulation in the Spleen: Differential Kinetics After Liposome-Mediated Elimination

1989 • 206 citations

Gene Therapy on Trial

2000 • 195 citations

Replication-selective adenoviruses as oncolytic agents

2000 • 195 citations

Intravenous administration of ONYX-015, a selectively replicating adenovirus, induces antitumoral efficacy.

1999 • 190 citations

Expression of alpha v beta 5 integrin is necessary for efficient adenovirus-mediated gene transfer in the human airway

1995 • 188 citations

Rac GTPase interacts specifically with phosphatidylinositol 3-kinase

1996 • 186 citations

Early events in the interaction of adenoviruses with Hela cells

1970 • 182 citations

Kupffer cell depletion by liposome-delivered drugs: Comparative activity of intracellular clodronate, propamidine, and ethylenediaminetetraacetic acid

1996 • 170 citations

FK506 Immunosuppression to Control the Immune Reactions Triggered by First-Generation Adenovirus-Mediated Gene Transfer

1995 • 160 citations

Persistence of Replication-Deficient Adenovirus-Mediated Gene Transfer in Lungs of Immune-Deficient (nu/nu) Mice

1995 • 158 citations

Kupffer cell depletion by liposome-delivered drugs: Comparative activity of intracellular clodronate, propamidine, and ethylenediaminetetraacetic acid

1996 • 157 citations

Transient immune blockade prevents formation of neutralizing antibody to recombinant adenovirus and allows repeated gene transfer to mouse liver.

1996 • 136 citations

Circumventing the immune response to adenovirus-mediated gene therapy.

1996 • 131 citations

A phase I trial of recombinant human interleukin-6 in patients with myelodysplastic syndromes and thrombocytopenia

1995 • 128 citations

Gene Therapy for Hemophilia B: Host Immunosuppression Prolongs the Therapeutic Effect of Adenovirus-Mediated Factor IX Expression

1995 • 127 citations

The early region 1B 55-kilodalton oncoprotein of adenovirus relieves growth restrictions imposed on viral replication by the cell cycle

1997 • 127 citations

The Replicative Capacities of Large E1B-Null Group A and Group C Adenoviruses Are Independent of Host Cell p53 Status

1999 • 122 citations

Toxicological Comparison of E2a-Deleted and First-Generation Adenoviral Vectors Expressingα₁-Antitrypsin after Systemic Delivery

1998 • 118 citations

Cytotoxic T-Lymphocyte Target Proteins and Their Major Histocompatibility Complex Class I Restriction in Response to Adenovirus Vectors Delivered to Mouse Liver

1998 • 118 citations

Macrophages in T cell line-mediated, demyelinating, and chronic relapsing experimental autoimmune encephalomyelitis in Lewis rats

1995 • 113 citations

ONYX-015 works synergistically with chemotherapy in lung cancer cell lines and primary cultures freshly made from lung cancer patients.

2000 • 111 citations

E3 Transcription Unit of Adenovirus

1995 • 111 citations

Association of human class I MHC alleles with the adenovirus E3/19K protein.

1994 • 108 citations

Characterization of Factors Involved in Modulating Persistence of Transgene Expression from Recombinant Adenovirus in the Mouse Lung

1997 • 107 citations

Mouse anti-adenovirus cytotoxic T lymphocytes. Inhibition of lysis by E3 gp19K but not E3 14.7K.

1989 • 105 citations

Macrophage depletion in the rat after intraperitoneal administration of liposome-encapsulated clodronate: Depletion kinetics and accelerated repopulation of peritoneal and omental macrophages by administration of freund's adjuvant

1995 • 105 citations

Vitronectin receptor antibodies inhibit infection of HeLa and A549 cells by adenovirus type 12 but not by adenovirus type 2

1994 • 98 citations

Use of Transient CD4 Lymphocyte Depletion to Prolong Transgene Expression of E1-Deleted Adenoviral Vectors

1996 • 93 citations

Adenovirus proteins that subvert host defenses

1994 • 90 citations

Adenovirus-mediated correction of the genetic defect in hepatocytes from patients with familial hypercholesterolemia

1993 • 87 citations

The constitutive expression of the immunomodulatory gp19k protein in E1-, E3- adenoviral vectors strongly reduces the host cytotoxic T cell response against the vector.

1995 • 85 citations

Anti-T Cell Receptor Monoclonal Antibody Prolongs Transgene Expression Following Adenovirus-MediatedIn VivoGene Transfer to Mouse Synovium

1996 • 84 citations

Role of Adenovirus Antigens in the Induction of Virus Neutralizing Antibody

1968 • 78 citations

Suppression of the immune response to an adenovirus vector and enhancement of intratumoral transgene expression by low-dose etoposide

1998 • 71 citations

Kupffer Cell Function in Host Defense

1987 • 66 citations

Selective Depletion of Liver and Splenic Macrophages Using Liposomes Encapsulating the Drug Dichloromethylene Diphosphonate: Effects on Antimicrobial Resistance

1991 • 64 citations

Interaction between HeLa cells and adenovirus type 2 virions neutralized by different antisera

1985 • 61 citations

Ultrastructural and Immunofluorescence Studies of Early Events in Adenovirus-HeLa Cell Interactions

1983 • 60 citations

Series Introduction: Replication-selective microbiological agents: fighting cancer with targeted germ warfare

2000 • 59 citations

Human marrow stromal cells: response to interleukin-6 (IL-6) and control of IL-6 expression

1989 • 55 citations

Kupffer cell elimination enhances development of liver schizonts of Plasmodium berghei in rats

1993 • 47 citations

Immunosuppression by FK506 Markedly Prolongs Expression of Adenovirus-Delivered Transgene in Skeletal Muscles of Adult Dystrophic [mdx] Mice

1995 • 43 citations

Novel proteins associated with MHC class I antigens in cells expressing the adenovirus protein E3/19K.

1993 • 34 citations

Adenovirus-Mediated Cytotoxicity of Chronic Lymphocytic Leukemia Cells

1999 • 26 citations

Mechanism of follicular trapping: localization of immune complexes and cell remnants after elimination and repopulation of different spleen cell populations.

1990 • 25 citations

Effects of liposome-encapsulated dichloromethylene diphosphonate on macrophage function and endotoxin-induced mortality

1994 • 24 citations

Model Systems for Studying the Effects of Adenovirus E3 Genes on Virulence In Vivo

1995 • 17 citations