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Insertion of the adenoviral E3 region into a recombinant viral vector prevents antiviral humoral and cellular immune responses and permits long-term gene expression

Data up to Jan 2025

Published1997
Citations208
References39

Total Citations Per Year

Abstract

References (39)

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy.

1994 • 1,599 citations

Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses

1995 • 1,048 citations

Methods in molecular biology

1991 • 938 citations

Manipulation of Adenovirus Vectors

2003 • 780 citations

An efficient and flexible system for construction of adenovirus vectors with insertions or deletions in early regions 1 and 3.

1994 • 743 citations

Adenovirus-mediated gene transfer transiently corrects the chloride transport defect in nasal epithelia of patients with cystic fibrosis

1993 • 669 citations

Cellular and humoral immune responses to adenoviral vectors containing factor IX gene: tolerization of factor IX and vector antigens allows for long-term expression.

1995 • 599 citations

Congenital familial nonhemolytic jaundice with kernicterus.

1952 • 541 citations

Inactivation of E2a in recombinant adenoviruses improves the prospect for gene therapy in cystic fibrosis

1994 • 460 citations

Packaging capacity and stability of human adenovirus type 5 vectors

1993 • 457 citations

Adenovirus–mediated in vivo gene transfer and expression in normal rat liver

1992 • 451 citations

The impact of developmental stage, route of administration and the immune system on adenovirus-mediated gene transfer.

1994 • 217 citations

The use of DNA viruses as vectors for gene therapy.

1994 • 206 citations

Sequence of exons and the flanking regions of human bilirubin-UDP-glucuronosyltransferase gene complex and identification of a genetic mutation in a patient with Crigler-Najjar syndrome, type I

1992 • 200 citations

FURTHER STUDIES ON THE TREATMENT OF CONGENITAL ADRENAL HYPERPLASIA WITH CORTISONE

1952 • 169 citations

Beta 2-microglobulin-, CD8+ T-cell-deficient mice survive inoculation with high doses of vaccinia virus and exhibit altered IgG responses.

1992 • 160 citations

Retrovirus-mediated transduction of adult hepatocytes.

1988 • 138 citations

Oral tolerization to adenoviral antigens permits long-term gene expression using recombinant adenoviral vectors.

1997 • 136 citations

Use of Human Adenovirus-based Vectors for Antigen Expression in Animals

1989 • 122 citations

Long Term Correction of Bilirubin-UDP-glucuronosyltransferase Deficiency in Gunn Rats by Administration of a Recombinant Adenovirus during the Neonatal Period

1996 • 117 citations

Induction of central tolerance by intrathymic inoculation of adenoviral antigens into the host thymus permits long-term gene therapy in Gunn rats.

1996 • 114 citations

E3 Transcription Unit of Adenovirus

1995 • 111 citations

Association of human class I MHC alleles with the adenovirus E3/19K protein.

1994 • 108 citations

Prolonged survival of pancreatic islet allografts mediated by adenovirus immunoregulatory transgenes.

1995 • 104 citations

Transient immunosuppression with FK506 permits long-term expression of therapeutic genes introduced into the liver using recombinant adenoviruses in the rat

1997 • 103 citations

Distribution of UDPglucuronosyltransferase in rat tissue.

1985 • 101 citations

Expression of human factor IX in rabbit hepatocytes by retrovirus-mediated gene transfer: potential for gene therapy of hemophilia B.

1990 • 94 citations

Determination of total and merecaptothanol-resistant antibody in the same serum sample.

1970 • 89 citations

The constitutive expression of the immunomodulatory gp19k protein in E1-, E3- adenoviral vectors strongly reduces the host cytotoxic T cell response against the vector.

1995 • 85 citations

Isolation and characterization of multiple forms of rat liver UDP-glucuronate glucuronosyltransferase

1986 • 80 citations

Characterization and tissue specificity of a monoclonal antibody against human uridine 5′-diphosphate-glucuronosyltransferase

1987 • 70 citations

Stabilization of transgene expression by incorporation of E3 region genes into an adenoviral factor IX vector and by transient anti-CD4 treatment of the host.

1996 • 64 citations

Bilirubin Mono- and diglucuronide formation by human liverIn vitro: Assay by high-pressure liquid chromatography

1981 • 63 citations

Novel proteins associated with MHC class I antigens in cells expressing the adenovirus protein E3/19K.

1993 • 34 citations

Azodipyrroles of unconjugated and conjugated bilirubin using diazotized ethyl anthranilate in dimethyl sulfoxide

1982 • 31 citations

Characterization of transgenic mice containing adenovirus early region 3 genomic DNA

1994 • 18 citations

Model Systems for Studying the Effects of Adenovirus E3 Genes on Virulence In Vivo

1995 • 17 citations

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Insertion of the adenoviral E3 region into a recombinant viral vector prevents antiviral… (1997) – Proceedings of the National Academy of Sciences | Metascience Observatory Explorer