Characterization of Factors Involved in Modulating Persistence of Transgene Expression from Recombinant Adenovirus in the Mouse Lung

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy.

1994 • 1,599 citations

Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses

1995 • 1,048 citations

In vivo transfer of the human cystic fibrosis transmembrane conductance regulator gene to the airway epithelium

1992 • 953 citations

Immune responses to transgene–encoded proteins limit the stability of gene expression after injection of replication–defective adenovirus vectors

1996 • 640 citations

Ablation of E2A in recombinant adenoviruses improves transgene persistence and decreases inflammatory response in mouse liver.

1994 • 627 citations

MHC class I-cestricted cytotoxic T lymphocytes to viral antigens destroy hepatocytes in mice infected with E1-deleted recombinant adenoviruses

1994 • 619 citations

Inactivation of E2a in recombinant adenoviruses improves the prospect for gene therapy in cystic fibrosis

1994 • 460 citations

Immune responses to viral antigens versus transgene product in the elimination of recombinant adenovirus-infected hepatocytes in vivo.

1996 • 383 citations

Inefficient gene transfer by adenovirus vector to cystic fibrosis airway epithelia of mice and humans

1994 • 373 citations

Adenovirus-Mediated Transfer of the CFTR Gene to Lung of Nonhuman Primates: Toxicity Study

1993 • 324 citations

Long–term hepatic adenovirus–mediated gene expression in mice following CTLA4Ig administration

1995 • 281 citations

Upregulation of class I major histocompatibility complex antigens by interferon gamma is necessary for T-cell-mediated elimination of recombinant adenovirus-infected hepatocytes in vivo.

1995 • 258 citations

Region E3 of adenovirus: A cassette of genes involved in host immunosurveillance and virus-cell interactions

1991 • 249 citations

Recombinant IL–12 prevents formation of blocking IgA antibodies to recombinant adenovirus and allows repeated gene therapy to mouse lung

1995 • 246 citations

Strain related variations in adenovirally mediated transgene expression from mouse hepatocytes in vivo: comparisons between immunocompetent and immunodeficient inbred strains.

1995 • 244 citations

Mobile inverted-repeat elements of the Tourist familyare associated with the genes of many cereal grasses.

1994 • 241 citations

"E3/19K" protein of adenovirus type 2 inhibits lysis of cytolytic T lymphocytes by blocking cell-surface expression of histocompatibility class I antigens.

1987 • 215 citations

Prolonged Transgene Expression in Cotton Rat Lung with Recombinant Adenoviruses Defective in E2a

1994 • 212 citations

Expression of alpha v beta 5 integrin is necessary for efficient adenovirus-mediated gene transfer in the human airway

1995 • 188 citations

Adenovirus-mediated gene transfer for cystic fibrosis: quantitative evaluation of repeated in vivo vector administration to the lung.

1994 • 188 citations

Development and Analysis of Recombinant Adenoviruses for Gene Therapy of Cystic Fibrosis

1993 • 162 citations

FK506 Immunosuppression to Control the Immune Reactions Triggered by First-Generation Adenovirus-Mediated Gene Transfer

1995 • 160 citations

Persistence of Replication-Deficient Adenovirus-Mediated Gene Transfer in Lungs of Immune-Deficient (nu/nu) Mice

1995 • 158 citations

Prolonged Metabolic Correction in Adult Ornithine Transcarbamylase-deficient Mice with Adenoviral Vectors

1996 • 155 citations

Acute Responses of Non-Human Primates to Airway Delivery of an Adenovirus Vector Containing the Human Cystic Fibrosis Transmembrane Conductance Regulator cDNA

1994 • 145 citations

Characterization of an Adenovirus Gene Transfer Vector Containing an E4 Deletion

1995 • 133 citations

Intratracheal Gene Delivery with Adenoviral Vector Induces Elevated Systemic IgG and Mucosal IgA Antibodies to Adenovirus andβ-Galactosidase

1995 • 127 citations

Lack of persistence of E1- recombinant adenoviral vectors containing a temperature-sensitive E2A mutation in immunocompetent mice and hemophilia B dogs.

1996 • 108 citations

Mouse anti-adenovirus cytotoxic T lymphocytes. Inhibition of lysis by E3 gp19K but not E3 14.7K.

1989 • 105 citations

Correction of cAMP-Stimulated Fluid Secretion in Cystic Fibrosis Airway Epithelia: Efficiency of Adenovirus-Mediated Gene Transfer In Vitro

1994 • 95 citations

Use of Transient CD4 Lymphocyte Depletion to Prolong Transgene Expression of E1-Deleted Adenoviral Vectors

1996 • 93 citations

Systematic Analysis of Repeated Gene Delivery into Animal Lungs with a Recombinant Adenovirus Vector

1996 • 89 citations

Humoral and cellular immune responses of nonhuman primates to long-term repeated lung exposure to Ad2/CFTR-2.

1996 • 88 citations

Anti-T Cell Receptor Monoclonal Antibody Prolongs Transgene Expression Following Adenovirus-MediatedIn VivoGene Transfer to Mouse Synovium

1996 • 84 citations

Deletion mutants of adenovirus 2: Isolation and initial characterization of virus carrying mutations near the right end of the viral genome

1981 • 83 citations

Specificities of Killing by Cytotoxic Lymphocytes Generated in Vivo and in Vitro to Syngeneic SV40 Transformed Cells

1977 • 81 citations

Evaluation of the Efficacy and Safety ofIn Vitro, Adenovirus-Mediated Transfer of the Human Cystic Fibrosis Transmembrane Conductance Regulator cDNA

1994 • 80 citations

Specificities of Killing by T Lymphocytes Generated against Syngeneic SV40 Transformants: Studies Employing Recombinants within the H-2 Complex

1979 • 74 citations

Specificity of the mouse cytotoxic T lymphocyte response to adenovirus 5. E1A is immunodominant in H-2b, but not in H-2d or H-2k mice.

1991 • 69 citations

The dual-function hamster receptor for amphotropic murine leukemia virus (MuLV), 10A1 MuLV, and gibbon ape leukemia virus is a phosphate symporter

1995 • 60 citations

Aerosol Delivery of aβ-Galactosidase Adenoviral Vector to the Lungs of Rodents

1995 • 48 citations

Surfactant Protein A-Directed Toxin Gene Kills Lung Cancer Cells In Vitro

1994 • 48 citations

Biological response of nonhuman primates to long-term repeated lung exposure to Ad2/CFTR-2.

1996 • 25 citations