Adenovirus proteins from both E1B reading frames are required for transformation of rodent cells by viral infection and DNA transfection

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

Methods in Enzymology , Vol

1966 • 26,261 citations

Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I

1977 • 12,015 citations

Selective extraction of polyoma DNA from infected mouse cell cultures

1967 • 5,357 citations

Characteristics of a Human Cell Line Transformed by DNA from Human Adenovirus Type 5

1977 • 4,801 citations

Screening λgt Recombinant Clones by Hybridization to Single Plaques in Situ

1977 • 4,696 citations

Rapid Isolation of Antigens from Cells with A Staphylococcal Protein A-Antibody Adsorbent: Parameters of the Interaction of Antibody-Antigen Complexes with Protein A

1975 • 3,054 citations

Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter.

1982 • 2,753 citations

Transformation of mammalian cells with genes from procaryotes and eucaryotes

1979 • 1,474 citations

Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cells

1982 • 883 citations

Isolation of adenovirus type 5 host range deletion mutants defective for transformation of rat embryo cells

1979 • 785 citations

Oligonucleotide-directed mutagenesis using M13-derived vectors: an efficient and general procedure for the production of point mutations in any fragment of DNA

1982 • 764 citations

The molecular biology of tumor viruses

1974 • 734 citations

Structure of the adenovirus 2 early mRNAs

1978 • 591 citations

Complex splicing patterns of RNAs from the early regions of adenovirus-2

1979 • 560 citations

Viral DNA in transformed cells

1974 • 429 citations

Selection of initiation sites by eucaryotic ribosomes: effect of inserting AUG triplets upstream from the coding sequence for preproinsulin

1984 • 390 citations

Resolving the functions of overlapping viral genes by site-specific mutagenesis at a mRNA splice site

1982 • 353 citations

Analysis of adenovirus transforming proteins from early regions 1A and 1B with antisera to inducible fusion antigens produced in Escherichia coli

1984 • 349 citations

Nucleotide sequences from the adenovirus-2 genome.

1982 • 345 citations

[75] Assay of transforming activity of tumor virus DNA

1980 • 331 citations

Host-range mutants of adenovirus type 5 defective for growth in HeLa cells

1977 • 330 citations

The Adenovirus E1B-55K Transforming Polypeptide Modulates Transport or Cytoplasmic Stabilization of Viral and Host Cell mRNAs

1986 • 301 citations

Amount of viral DNA in the genome of cells transformed by adenovirus type 2

1973 • 297 citations

The 2.2 kb E1b mRNA of human Ad12 and Ad5 codes for two tumor antigens starting at different AUG triplets

1981 • 290 citations

Promoters and heterogeneous 5′ termini of the messenger RNAs of adenovirus serotype 2

1981 • 289 citations

Size and location of the transforming region in human adenovirus type 5 DNA

1974 • 238 citations

Adenovirus E1B proteins are required for accumulation of late viral mRNA and for effects on cellular mRNA translation and transport.

1985 • 234 citations

Initiation of translation at internal AUG codons in mammalian cells

1984 • 231 citations

Adenovirus early region 1B 58,000-dalton tumor antigen is physically associated with an early region 4 25,000-dalton protein in productively infected cells

1984 • 221 citations

Defective transforming capacity of adenovirus type 5 host-range mutants

1978 • 211 citations

The gene for polypeptide IX of adenovirus type 2 and its unspliced messenger RNA

1980 • 204 citations

Deletion of the gene encoding the adenovirus 5 early region 1b 21,000-molecular-weight polypeptide leads to degradation of viral and host cell DNA

1984 • 195 citations

A monoclonal antibody detecting the adenovirus type 5 E 1 b-58Kd tumor antigen: Characterization of the E 1 b-58Kd tumor antigen in adenovirus-infected and -transformed cells

1982 • 188 citations

Adenovirus type 5 early region 1b gene product is required for efficient shutoff of host protein synthesis

1984 • 186 citations

Transformation with specific fragments of adenovirus DNAs I. Isolation of specific fragments with transforming activity of adenovirus 2 and 5 DNA

1977 • 170 citations

Mutations in the gene encoding the adenovirus early region 1B 19,000-molecular-weight tumor antigen cause the degradation of chromosomal DNA

1984 • 156 citations

Initiation of translation of the cauliflower mosaic virus genome from a polycistronic mRNA: evidence from deletion mutagenesis

1984 • 152 citations

Dissection of overlapping functions within the adenovirus type 5 E1A gene.

1984 • 146 citations

Localization of the E1 B proteins of adenovirus 5 in transformed cells, as revealed by interaction with monoclonal antibodies

1985 • 145 citations

The adenovirus E1B-55K transforming polypeptide modulates transport or cytoplasmic stabilization of viral and host cell mRNAs.

1986 • 143 citations

Adenovirus 2 lp+ locus codes for a 19 kd tumor antigen that plays an essential role in cell transformation

1983 • 128 citations

Loop structures in hybrids of early RNA and the separated strands of adenovirus DNA.

1977 • 126 citations

Analysis of type 5 adenovirus transformation with a cloned rat embryo cell line (CREF).

1982 • 126 citations

Sensitive determination of pyrimidine dimers in DNA of UV-irradiated mammalian cells Introduction of T4 endonuclease V into frozen and thawed cells

1981 • 124 citations

Identification of human adenovirus early region 1 products by using antisera against synthetic peptides corresponding to the predicted carboxy termini

1983 • 118 citations

Transformation of primary rat embryo cells by adenovirus type 2.

1967 • 115 citations

Viral nucleic acid sequences in transformed cells

1976 • 112 citations

Genetic studies with tumorigenic adenoviruses

1968 • 109 citations

Isolation of type 5 adenovirus mutants with a cold-sensitive host range phenotype: Genetic evidence of an adenovirus transformation maintenance function

1982 • 103 citations

Transformation by human adenoviruses

1984 • 98 citations

Enhanced expression of adenovirus transforming proteins

1982 • 94 citations

19-kDa tumor antigen coded by early region E1b of adenovirus 2 is required for efficient synthesis and for protection of viral DNA.

1984 • 92 citations

Characterization of tumor antigens in cells transformed by fragments of adenovirus type 5 DNA

1979 • 88 citations

The isolation and identification of the adenovirus group C tumor antigens

1977 • 84 citations

Nuclear envelope localization of an adenovirus tumor antigen maintains the integrity of cellular DNA.

1984 • 82 citations

Intracellular localization of adenovirus type 5 tumor antigens in productively infected cells

1983 • 79 citations

Early viral proteins in HeLa cells infected with adenovirus type 5 host range mutants

1980 • 72 citations

Tumor antigens of human ad5 in transformed cells and in cells infected with transformation-defective host-range mutants

1979 • 71 citations

Mutation of a termination codon affects src initiation.

1984 • 68 citations

Identification of adenovirus genes that require template replication for expression

1983 • 68 citations

Tn5 mutagenesis of the transforming genes of human adenovirus type 5

1982 • 68 citations

Accumulation of early and intermediate mRNA species during subgroup C adenovirus productive infections

1984 • 67 citations

Early region 1B of adenovirus 2 encodes two coterminal proteins of 495 and 155 amino acid residues

1984 • 65 citations

Purification of a native membrane-associated adenovirus tumor antigen

1982 • 63 citations

Mapping of an adenovirus function involved in the inhibition of DNA degradation

1982 • 61 citations

Degradation of intracellular DNA in KB cells infected with cyt mutants of human adenovirus type 12

1981 • 60 citations

Effect on transformation of mutations in the early region 1b-encoded 21- and 55-kilodalton proteins of adenovirus 5

1984 • 60 citations

Evidence that a second tumor antigen coded by adenovirus early gene region E1a is required for efficient cell transformation.

1985 • 57 citations

Organization of early region 1B of human adenovirus type 2: identification of four differentially spliced mRNAs

1985 • 56 citations

Role of the adenovirus early region 1B tumor antigens in transformation and lytic infection

1986 • 54 citations

Morphological transformation of human adenoviruses is determined to a large extent by gene products of region E1A

1983 • 53 citations

Adenovirus cyt+ locus, which controls cell transformation and tumorigenicity, is an allele of lp+ locus, which codes for a 19-kilodalton tumor antigen

1984 • 52 citations

Human adenovirus 2 E1B-19K and E1B-53K tumor antigens: antipeptide antibodies targeted to the NH2 and COOH termini

1983 • 50 citations

Control of adenovirus E1B mRNA synthesis by a shift in the activities of RNA splice sites.

1984 • 45 citations

Transformation of rat cells by cyt mutants of adenovirus type 12 and mutants of adenovirus type 5

1983 • 39 citations

Physical location of host-range mutations of adenovirus type 5; deletion and marker-rescue mapping

1980 • 39 citations

Adenovirus terminal protein protects single stranded DNA from digestion by a cellular exonuclease

1980 • 37 citations

regA protein of bacteriophage T4D: identification, schedule of synthesis, and autogenous regulation

1979 • 36 citations

Identification and purification of a protein encoded by the human adenovirus type 2 transforming region

1982 • 36 citations

Transformation of rodent cells by DNA extracted from transformation-defective adenovirus mutants

1983 • 33 citations

Morphological transformation of established rodent cell lines by high-level expression of the adenovirus type 2 E1a gene.

1986 • 31 citations

Establishment and characterization of hamster cell lines transformed by restriction endonuclease fragments of adenovirus 5

1984 • 29 citations

Studies on the Phosphorylation of the 58000 Dalton Early Region 1B Protein of Human Adenovirus Type 5

1983 • 29 citations

The Kinetics of Synthesis of Early Viral Proteins in KB Cells Infected with Wild-type and Transformation-defective Host-range Mutants of Human Adenovirus Type 5

1984 • 26 citations

Polypeptides encoded by transforming region E1b of human adenovirus 2: Immunoprecipitation from transformed and infected cells and cell-free translation of Elb-specific mRNA

1982 • 24 citations

In vitro synthesis of adenovirus type 5 T antigens. II. Translation of virus-specific RNA from cells transformed by fragments of adenovirus type 5 DNA

1981 • 20 citations

Antibody directed to a synthetic peptide encoding the NH2-terminal 16 amino acids of the adenovirus type 2 E1B-53K tumor antigen recognizes the E1B-20K tumor antigen

1984 • 19 citations

The Messenger RNAs from the Transforming Region of Human Adenoviruses

1983 • 14 citations

The Molecular Biology of Adenoviruses 1

1983 • 9 citations