A phase I study of Onyx-015, an E1B attenuated adenovirus, administered intratumorally to patients with recurrent head and neck cancer.

p53 Mutations in Human Cancers

1991 • 8,133 citations

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

1990 • 3,896 citations

Amplification of a gene encoding a p53-associated protein in human sarcomas

1992 • 1,959 citations

An Adenovirus Mutant That Replicates Selectively in p53- Deficient Human Tumor Cells

1996 • 1,735 citations

mdm2 expression is induced by wild type p53 activity.

1993 • 1,286 citations

Barriers to Drug Delivery in Solid Tumors

1994 • 1,064 citations

ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents

1997 • 945 citations

Identification and characterization of the blood vessels of solid tumors that are leaky to circulating macromolecules.

1988 • 680 citations

A phase III randomized study comparing cisplatin and fluorouracil as single agents and in combination for advanced squamous cell carcinoma of the head and neck.

1992 • 617 citations

The incidence of p53 mutations increases with progression of head and neck cancer.

1993 • 602 citations

Adenoviruses as Gene-Delivery Vehicles

1996 • 480 citations

Adenovirus proteins from both E1B reading frames are required for transformation of rodent cells by viral infection and DNA transfection

1987 • 394 citations

Adenovirus-mediated p53 gene transfer in patients with advanced recurrent head and neck squamous cell carcinoma.

1998 • 379 citations

Human papillomavirus E6 proteins bind p53 in vivo and abrogate p53-mediated repression of transcription.

1992 • 272 citations

Recombinant IL–12 prevents formation of blocking IgA antibodies to recombinant adenovirus and allows repeated gene therapy to mouse lung

1995 • 246 citations

p53-dependent cell death/apoptosis is required for a productive adenovirus infection

1998 • 231 citations

Adenovirus infection stimulates the Raf/MAPK signaling pathway and induces interleukin-8 expression

1997 • 231 citations

“Sero-Switch” Adenovirus-MediatedIn VivoGene Transfer: Circumvention of Anti-Adenovirus Humoral Immune Defenses Against Repeat Adenovirus Vector Administration by Changing the Adenovirus Serotype

1996 • 207 citations

High incidence of p53 alterations (mutation, deletion, overexpression) in head and neck primary tumors and metastases; absence of correlation with clinical outcome. Frequent protein overexpression in normal epithelium and in early non-invasive lesions.

1995 • 198 citations

The early region 1B 55-kilodalton oncoprotein of adenovirus relieves growth restrictions imposed on viral replication by the cell cycle

1997 • 127 citations

Efficacy of a replication-competent adenovirus (ONYX-015) following intratumoral injection: Intratumoral spread and distribution effects

1999 • 118 citations

Poly (lactic-glycolic) acid copolymer encapsulation of recombinant adenovirus reduces immunogenicity in vivo

1998 • 105 citations

Chemotherapy for squamous cell carcinoma of head and neck: The future is now

1996 • 87 citations

Overview of platinum chemotherapy in head and neck cancer.

1994 • 73 citations

Development of Replication-Defective Herpes Simplex Virus Vectors

2003 • 73 citations

High adenoviral loads stimulate NFκB-dependent gene expression in human vascular smooth muscle cells

1998 • 67 citations

The Earth's Elements

1994 • 57 citations

Surgical management of local and regional recurrent head and neck squamous cell carcinoma

1998 • 24 citations

Modem brachytherapy: Current state and future prospects

1997 • 20 citations