Expression of alpha v beta 5 integrin is necessary for efficient adenovirus-mediated gene transfer in the human airway

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1992 • 9,986 citations

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1993 • 2,182 citations

Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses

1995 • 1,048 citations

In vivo transfer of the human cystic fibrosis transmembrane conductance regulator gene to the airway epithelium

1992 • 953 citations

Administration of an adenovirus containing the human CFTR cDNA to the respiratory tract of individuals with cystic fibrosis

1994 • 829 citations

Stepwise dismantling of adenovirus 2 during entry into cells

1993 • 810 citations

Inactivation of E2a in recombinant adenoviruses improves the prospect for gene therapy in cystic fibrosis

1994 • 460 citations

Inefficient gene transfer by adenovirus vector to cystic fibrosis airway epithelia of mice and humans

1994 • 373 citations

Virus-Receptor Interaction in an Adenovirus System

1968 • 343 citations

Direct gene transfer of human CFTR into human bronchial epithelia of xenografts with E1–deleted adenoviruses

1993 • 303 citations

Upregulation of integrins alpha v beta 3 and alpha v beta 5 on human monocytes and T lymphocytes facilitates adenovirus-mediated gene delivery

1995 • 292 citations

Mutations that alter an Arg-Gly-Asp (RGD) sequence in the adenovirus type 2 penton base protein abolish its cell-rounding activity and delay virus reproduction in flat cells

1993 • 276 citations

Human adenovirus-host cell interactions: comparative study with members of subgroups B and C

1990 • 248 citations

Safety and efficacy of repetitive adenovirus–mediated transfer of CFTR cDNA to airway epithelia of primates and cotton rats

1994 • 216 citations

Adenovirus-Mediated Transfer of the CFTR Gene to Lung of Nonhuman Primates: Biological Efficacy Study

1993 • 196 citations

Distribution of Integrin Cell Adhesion Receptors in Normal and Malignant Lung Tissue

1992 • 163 citations

Infectious entry pathway of adenovirus type 2

1991 • 132 citations

Vitronectin receptor antibodies inhibit infection of HeLa and A549 cells by adenovirus type 12 but not by adenovirus type 2

1994 • 98 citations

Gene therapy in a xenograft model of cystic fibrosis lung corrects chloride transport more effectively than the sodium defect

1995 • 95 citations

Distribution of Integrin Cell Adhesion Receptors on Normal Bronchial Epithelial Cells and Lung Cancer Cells In Vitro and In Vivo

1993 • 92 citations

Distribution of integrins alpha v beta 6 and alpha 9 beta 1 and their known ligands, fibronectin and tenascin, in human airways.

1995 • 73 citations

Characterization of stem cells in human airway capable of reconstituting a fully differentiated bronchial epithelium

1995 • 40 citations