Multiple glucocorticoid receptor isoforms and mechanisms of post-translational modification

Antiinflammatory Action of Glucocorticoids — New Mechanisms for Old Drugs

2005 • 2,909 citations

Amino Acid Sequences Common to Rapidly Degraded Proteins: The PEST Hypothesis

1986 • 2,566 citations

The Hypothalamic–Pituitary–Adrenal Axis and Immune-Mediated Inflammation

1995 • 2,525 citations

The coregulator exchange in transcriptional functions of nuclear receptors

2000 • 2,219 citations

Primary structure and expression of a functional human glucocorticoid receptor cDNA

1985 • 1,851 citations

Steroid Receptor Interactions with Heat Shock Protein and Immunophilin Chaperones*

1997 • 1,678 citations

PEST sequences and regulation by proteolysis

1996 • 1,606 citations

Antitumor promotion and antiinflammation: Down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone

1990 • 1,605 citations

Acetylation and deacetylation of non-histone proteins

2005 • 1,529 citations

Anti-inflammatory Actions of Glucocorticoids: Molecular Mechanisms

1998 • 1,516 citations

Regulation of Signaling Protein Function and Trafficking by the hsp90/hsp70-Based Chaperone Machinery

2003 • 1,470 citations

HDAC6 Regulates Hsp90 Acetylation and Chaperone-Dependent Activation of Glucocorticoid Receptor

2005 • 1,074 citations

Two signals mediate hormone-dependent nuclear localization of the glucocorticoid receptor.

1987 • 999 citations

Human PAD4 Regulates Histone Arginine Methylation Levels via Demethylimination

2004 • 955 citations

Determinants of target gene specificity for steroid/thyroid hormone receptors

1989 • 954 citations

Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation.

1995 • 926 citations

CREB-binding Protein and p300 in Transcriptional Regulation

2001 • 847 citations

Crystal Structure of the Glucocorticoid Receptor Ligand Binding Domain Reveals a Novel Mode of Receptor Dimerization and Coactivator Recognition

2002 • 787 citations

Polymeric Chains of SUMO-2 and SUMO-3 Are Conjugated to Protein Substrates by SAE1/SAE2 and Ubc9

2001 • 782 citations

Multiple and cooperative trans-activation domains of the human glucocorticoid receptor

1988 • 705 citations

Histone methylation versus histone acetylation: new insights into epigenetic regulation

2001 • 689 citations

Evolution of vertebrate steroid receptors from an ancestral estrogen receptor by ligand exploitation and serial genome expansions

2001 • 681 citations

Steroid Receptor Interactions with Heat Shock Protein and Immunophilin Chaperones

1997 • 649 citations

Gene profiling reveals unknown enhancing and suppressive actions of glucocorticoids on immune cells

2002 • 580 citations

Histone Methylation

2002 • 525 citations

CELL CYCLE REGULATION AND APOPTOSIS

1998 • 516 citations

Something about SUMO inhibits transcription

2005 • 491 citations

Glucocorticoids inhibit MAP kinase via increased expression and decreased degradation of MKP-1

2001 • 466 citations

The Dominant Negative Activity of the Human Glucocorticoid Receptor β Isoform

1999 • 440 citations

Translational Regulatory Mechanisms Generate N-Terminal Glucocorticoid Receptor Isoforms with Unique Transcriptional Target Genes

2005 • 421 citations

The structure of the nuclear hormone receptors

1999 • 414 citations

Cross-Talk between Nuclear Factor-κB and the Steroid Hormone Receptors: Mechanisms of Mutual Antagonism

1998 • 405 citations

Mechanisms of glucocorticoid receptor signaling during inflammation

2004 • 400 citations

The genomic structure of the human glucocorticoid receptor.

1991 • 397 citations

Proteasome-mediated Glucocorticoid Receptor Degradation Restricts Transcriptional Signaling by Glucocorticoids

2001 • 381 citations

The human glucocorticoid receptor: One gene, multiple proteins and diverse responses

2005 • 366 citations

Deciphering the Phosphorylation “Code” of the Glucocorticoid Receptor in Vivo

2002 • 309 citations

Modulation of Glucocorticoid Receptor Function via Phosphorylation

2004 • 307 citations

Increased Glucocorticoid Receptor β in Airway Cells of Glucocorticoid-insensitive Asthma

1999 • 294 citations

Identification of Human Glucocorticoid Receptor Complementary DNA Clones by Epitope Selection

1985 • 277 citations

Glucocorticoid resistance in asthma is associated with elevated in vivo expression of the glucocorticoid receptor β-isoform

2000 • 272 citations

Mitogen-Activated and Cyclin-Dependent Protein Kinases Selectively and Differentially Modulate Transcriptional Enhancement by the Glucocorticoid Receptor

1997 • 271 citations

Mouse Glucocorticoid Receptor Phosphorylation Status Influences Multiple Functions of the Receptor Protein

1997 • 263 citations

Gene regulation by the glucocorticoid receptor: Structure:function relationship

2005 • 243 citations

Intracellular Glucocorticoid Signaling: A Formerly Simple System Turns Stochastic

2005 • 234 citations

How many nuclear hormone receptors are there in the human genome?

2001 • 231 citations

Regulation of coactivator complex assembly and function by protein arginine methylation and demethylimination

2005 • 226 citations

The Origin and Functions of Multiple Human Glucocorticoid Receptor Isoforms

2004 • 209 citations

Transactivation Functions of the N-Terminal Domains of Nuclear Hormone Receptors: Protein Folding and Coactivator Interactions

2003 • 202 citations

Expression and Subcellular Distribution of the β-Isoform of the Human Glucocorticoid Receptor*

1997 • 193 citations

Molecular Origins for the Dominant Negative Function of Human Glucocorticoid Receptor Beta

2003 • 172 citations

Small ubiquitin-related modifier-1 (SUMO-1) modification of the glucocorticoid receptor

2002 • 170 citations

Regulation of the Dynamics of hsp90 Action on the Glucocorticoid Receptor by Acetylation/Deacetylation of the Chaperone

2005 • 161 citations

Potentiation of Glucocorticoid Receptor Transcriptional Activity by Sumoylation

2002 • 152 citations

Mechanisms of Glucocorticoid-receptor-mediated Repression of Gene Expression

1999 • 152 citations

Multiple Promoters Exist in the Human GR Gene, One of Which Is Activated by Glucocorticoids

2001 • 150 citations

Glucocorticoid receptor phosphorylation: Overview, function and cell cycle-dependence

1998 • 142 citations

Phosphorylation and Inhibition of Rat Glucocorticoid Receptor Transcriptional Activation by Glycogen Synthase Kinase-3 (GSK-3)

1998 • 137 citations

Corticosteroid Resistance in Airway Disease

2004 • 135 citations

Glucocorticoid receptor structure and function in glucocorticoid-resistant small cell lung carcinoma cells.

1996 • 126 citations

Alternatively spliced glucocorticoid receptor messenger RNAs in glucocorticoid-resistant human multiple myeloma cells.

1993 • 125 citations

SUMO conjugation and deconjugation

2000 • 120 citations

Modulating molecular chaperone Hsp90 functions through reversible acetylation

2005 • 116 citations

Hormone-dependent phosphorylation of the glucocorticoid receptor occurs mainly in the amino-terminal transactivation domain.

1990 • 112 citations

Role of Acidic and Phosphorylated Residues in Gene Activation by the Glucocorticoid Receptor

1995 • 107 citations

Linking the ubiquitin–proteasome pathway to chromatin remodeling/modification by nuclear receptors

2005 • 105 citations

Expression and Subcellular Distribution of the -Isoform of the Human Glucocorticoid Receptor

1997 • 100 citations

The promoter and first, untranslated exon of the human glucocorticoid receptor gene are GC rich but lack consensus glucocorticoid receptor element sites.

1990 • 99 citations

Site-directed mutagenesis of the phosphorylation sites in the mouse glucocorticoid receptor.

1993 • 96 citations

Histone Deacetylases as Transcriptional Activators? Role Reversal in Inducible Gene Regulation

2005 • 92 citations

A variant glucocorticoid receptor messenger RNA is expressed in multiple myeloma patients.

1995 • 88 citations

Expression and structural analysis of glucocorticoid receptor isoform gamma in human leukaemia cells using an isoform‐specific real‐time polymerase chain reaction approach

2003 • 87 citations

Cross-Talk between Nuclear Factor- B and the Steroid Hormone Receptors: Mechanisms of Mutual Antagonism

1997 • 86 citations

Hormonal regulation of the nuclear localization signals of the human glucocorticosteroid receptor

1992 • 80 citations

Characterization of the Human Glucocorticoid Receptor Promoter

1995 • 79 citations

Immunocytochemical analysis of hormone mediated nuclear translocation of wild type and mutant glucocorticoid receptors

1995 • 67 citations

CELL CYCLE EVENTS IN THE HYDROCORTISONE REGULATION OF ALKALINE PHOSPHATASE IN HELA S3 CELLS

1969 • 66 citations

Adrenal and sex steroid receptor evolution: environmental implications

2001 • 64 citations

Multiple Promoters Exist in the Human GR Gene, One of Which Is Activated by Glucocorticoids

2001 • 41 citations

Heteronuclear nuclear magnetic resonance assignments, structure and dynamics of SUMO-1, a human ubiquitin-like protein

2001 • 31 citations

The truncated glucocorticoid receptor in the P1798 mouse lymphosarcoma is associated with resistance to glucocorticoid lysis but not to other glucocorticoid-induced functions.

1991 • 16 citations

ATP-stimulated translocation promoter that enhances the nuclear binding of activated glucocorticoid receptor complex. Biochemical properties and its function (mini-review).

1993 • 8 citations