Molecular Origins for the Dominant Negative Function of Human Glucocorticoid Receptor Beta
Data up to Jan 2025
Total Citations Per Year
Abstract
References (46)
Protein secondary structure prediction based on position-specific scoring matrices 1 1Edited by G. Von Heijne
1999 • 5,382 citations
Prediction of Protein Secondary Structure at Better than 70% Accuracy
1993 • 2,958 citations
Primary structure and expression of a functional human glucocorticoid receptor cDNA
1985 • 1,851 citations
[22] Using CLUSTAL for multiple sequence alignments
1996 • 1,594 citations
Dominant negative mutations in human PPARγ associated with severe insulin resistance, diabetes mellitus and hypertension
1999 • 1,350 citations
[32] GOR method for predicting protein secondary structure from amino acid sequence
1996 • 1,239 citations
Two signals mediate hormone-dependent nuclear localization of the glucocorticoid receptor.
1987 • 999 citations
Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation.
1995 • 926 citations
Crystal Structure of the Glucocorticoid Receptor Ligand Binding Domain Reveals a Novel Mode of Receptor Dimerization and Coactivator Recognition
2002 • 787 citations
GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors.
1996 • 702 citations
Atomic structure of progesterone complexed with its receptor
1998 • 654 citations
Glucocorticoid receptor beta, a potential endogenous inhibitor of glucocorticoid action in humans.
1995 • 636 citations
Protein encoded by v-erbA functions as a thyroid-hormone receptor antagonist
1989 • 599 citations
Further developments of protein secondary structure prediction using information theory
1987 • 573 citations
The Human Glucocorticoid Receptor β Isoform
1996 • 553 citations
Exploiting the past and the future in protein secondary structure prediction
1999 • 493 citations
Identification and application of the concepts important for accurate and reliable protein secondary structure prediction
1996 • 463 citations
Proinflammatory cytokines regulate human glucocorticoid receptor gene expression and lead to the accumulation of the dominant negative β isoform: A mechanism for the generation of glucocorticoid resistance
2001 • 460 citations
Nuclear receptor ligand-binding domains: three-dimensional structures, molecular interactions and pharmacological implications
2000 • 459 citations
The Dominant Negative Activity of the Human Glucocorticoid Receptor β Isoform
1999 • 440 citations
Association of Glucocorticoid Insensitivity with Increased Expression of Glucocorticoid Receptor β
1997 • 413 citations
Cross-Talk between Nuclear Factor-κB and the Steroid Hormone Receptors: Mechanisms of Mutual Antagonism
1998 • 405 citations
The genomic structure of the human glucocorticoid receptor.
1991 • 397 citations
A Comparison of the Activity, Sequence Specificity, and CRM1-Dependence of Different Nuclear Export Signals
2000 • 392 citations
Seventy-five percent accuracy in protein secondary structure prediction
1997 • 377 citations
SOPM: a self-optimized method for protein secondary structure prediction
1994 • 329 citations
Nuclear-Receptor Ligands and Ligand-Binding Domains
1999 • 314 citations
Increased Glucocorticoid Receptor β in Airway Cells of Glucocorticoid-insensitive Asthma
1999 • 294 citations
Identification of Human Glucocorticoid Receptor Complementary DNA Clones by Epitope Selection
1985 • 277 citations
Glucocorticoid resistance in asthma is associated with elevated in vivo expression of the glucocorticoid receptor β-isoform
2000 • 272 citations
Expression of glucocorticoid receptor β in lymphocytes of patients with glucocorticoid-resistant ulcerative colitis
2000 • 251 citations
Improved performance in protein secondary structure prediction by inhomogeneous score combination.
1999 • 224 citations
High Constitutive Glucocorticoid Receptor β in Human Neutrophils Enables Them to Reduce Their Spontaneous Rate of Cell Death in Response to Corticosteroids
2001 • 211 citations
Binding of Ligands and Activation of Transcription by Nuclear Receptors
2001 • 204 citations
Glucocorticoid Receptor Homodimers and Glucocorticoid-Mineralocorticoid Receptor Heterodimers Form in the Cytoplasm through Alternative Dimerization Interfaces
2001 • 153 citations
The Peptide Near the C Terminus Regulates Receptor CAR Nuclear Translocation Induced by Xenochemicals in Mouse Liver
2001 • 146 citations
ANTHEPROT: An integrated protein sequence analysis software with client/server capabilities
2001 • 134 citations
Powerful dominant negative mutants of the human estrogen receptor
1993 • 119 citations
Imbalanced Expression of the Glucocorticoid Receptor Isoforms in Cultured Lymphocytes from a Patient with Systemic Glucocorticoid Resistance and Chronic Lymphocytic Leukemia
1999 • 118 citations
Modulation by vitamin B6 of glucocorticoid receptor-mediated gene expression requires transcription factors in addition to the glucocorticoid receptor.
1993 • 95 citations
Analysis of Mechanisms That Determine Dominant Negative Estrogen Receptor Effectiveness
1995 • 73 citations
Structure/Function of the Human Glucocorticoid Receptor: Tyrosine 735 Is Important for Transactivation
1999 • 55 citations
Glucocorticoid Resistant Syndromes—Molecular Basis andClinical Presentations
1996 • 53 citations
Role of the C terminus of the glucocorticoid receptor in hormone binding and agonist/antagonist discrimination.
1996 • 48 citations
Retinoid X Receptor (RXR) Agonist-Induced Activation of Dominant-Negative RXR-Retinoic Acid Receptor α403 Heterodimers Is Developmentally Regulated during Myeloid Differentiation
1999 • 36 citations
Residues in the Ligand Binding Domain That Confer Progestin or Glucocorticoid Specificity and Modulate the Receptor Transactivation Capacity
2000 • 34 citations