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Molecular Origins for the Dominant Negative Function of Human Glucocorticoid Receptor Beta

Data up to Jan 2025

Published2003
Citations172
References46

Total Citations Per Year

Abstract

References (46)

Protein secondary structure prediction based on position-specific scoring matrices 1 1Edited by G. Von Heijne

1999 • 5,382 citations

Prediction of Protein Secondary Structure at Better than 70% Accuracy

1993 • 2,958 citations

Primary structure and expression of a functional human glucocorticoid receptor cDNA

1985 • 1,851 citations

[22] Using CLUSTAL for multiple sequence alignments

1996 • 1,594 citations

Dominant negative mutations in human PPARγ associated with severe insulin resistance, diabetes mellitus and hypertension

1999 • 1,350 citations

[32] GOR method for predicting protein secondary structure from amino acid sequence

1996 • 1,239 citations

Two signals mediate hormone-dependent nuclear localization of the glucocorticoid receptor.

1987 • 999 citations

Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation.

1995 • 926 citations

Crystal Structure of the Glucocorticoid Receptor Ligand Binding Domain Reveals a Novel Mode of Receptor Dimerization and Coactivator Recognition

2002 • 787 citations

GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors.

1996 • 702 citations

Atomic structure of progesterone complexed with its receptor

1998 • 654 citations

Glucocorticoid receptor beta, a potential endogenous inhibitor of glucocorticoid action in humans.

1995 • 636 citations

Protein encoded by v-erbA functions as a thyroid-hormone receptor antagonist

1989 • 599 citations

Further developments of protein secondary structure prediction using information theory

1987 • 573 citations

The Human Glucocorticoid Receptor β Isoform

1996 • 553 citations

Exploiting the past and the future in protein secondary structure prediction

1999 • 493 citations

Identification and application of the concepts important for accurate and reliable protein secondary structure prediction

1996 • 463 citations

Proinflammatory cytokines regulate human glucocorticoid receptor gene expression and lead to the accumulation of the dominant negative β isoform: A mechanism for the generation of glucocorticoid resistance

2001 • 460 citations

Nuclear receptor ligand-binding domains: three-dimensional structures, molecular interactions and pharmacological implications

2000 • 459 citations

The Dominant Negative Activity of the Human Glucocorticoid Receptor β Isoform

1999 • 440 citations

Association of Glucocorticoid Insensitivity with Increased Expression of Glucocorticoid Receptor β

1997 • 413 citations

Cross-Talk between Nuclear Factor-κB and the Steroid Hormone Receptors: Mechanisms of Mutual Antagonism

1998 • 405 citations

The genomic structure of the human glucocorticoid receptor.

1991 • 397 citations

A Comparison of the Activity, Sequence Specificity, and CRM1-Dependence of Different Nuclear Export Signals

2000 • 392 citations

Seventy-five percent accuracy in protein secondary structure prediction

1997 • 377 citations

SOPM: a self-optimized method for protein secondary structure prediction

1994 • 329 citations

Nuclear-Receptor Ligands and Ligand-Binding Domains

1999 • 314 citations

Increased Glucocorticoid Receptor β in Airway Cells of Glucocorticoid-insensitive Asthma

1999 • 294 citations

Identification of Human Glucocorticoid Receptor Complementary DNA Clones by Epitope Selection

1985 • 277 citations

Glucocorticoid resistance in asthma is associated with elevated in vivo expression of the glucocorticoid receptor β-isoform

2000 • 272 citations

Expression of glucocorticoid receptor β in lymphocytes of patients with glucocorticoid-resistant ulcerative colitis

2000 • 251 citations

Improved performance in protein secondary structure prediction by inhomogeneous score combination.

1999 • 224 citations

High Constitutive Glucocorticoid Receptor β in Human Neutrophils Enables Them to Reduce Their Spontaneous Rate of Cell Death in Response to Corticosteroids

2001 • 211 citations

Binding of Ligands and Activation of Transcription by Nuclear Receptors

2001 • 204 citations

Glucocorticoid Receptor Homodimers and Glucocorticoid-Mineralocorticoid Receptor Heterodimers Form in the Cytoplasm through Alternative Dimerization Interfaces

2001 • 153 citations

The Peptide Near the C Terminus Regulates Receptor CAR Nuclear Translocation Induced by Xenochemicals in Mouse Liver

2001 • 146 citations

ANTHEPROT: An integrated protein sequence analysis software with client/server capabilities

2001 • 134 citations

Powerful dominant negative mutants of the human estrogen receptor

1993 • 119 citations

Imbalanced Expression of the Glucocorticoid Receptor Isoforms in Cultured Lymphocytes from a Patient with Systemic Glucocorticoid Resistance and Chronic Lymphocytic Leukemia

1999 • 118 citations

Modulation by vitamin B6 of glucocorticoid receptor-mediated gene expression requires transcription factors in addition to the glucocorticoid receptor.

1993 • 95 citations

Analysis of Mechanisms That Determine Dominant Negative Estrogen Receptor Effectiveness

1995 • 73 citations

Structure/Function of the Human Glucocorticoid Receptor: Tyrosine 735 Is Important for Transactivation

1999 • 55 citations

Glucocorticoid Resistant Syndromes—Molecular Basis andClinical Presentations

1996 • 53 citations

Role of the C terminus of the glucocorticoid receptor in hormone binding and agonist/antagonist discrimination.

1996 • 48 citations

Retinoid X Receptor (RXR) Agonist-Induced Activation of Dominant-Negative RXR-Retinoic Acid Receptor α403 Heterodimers Is Developmentally Regulated during Myeloid Differentiation

1999 • 36 citations

Residues in the Ligand Binding Domain That Confer Progestin or Glucocorticoid Specificity and Modulate the Receptor Transactivation Capacity

2000 • 34 citations

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