Histone methylation versus histone acetylation: new insights into epigenetic regulation

Crystal structure of the nucleosome core particle at 2.8 Å resolution

1997 • 8,906 citations

The language of covalent histone modifications

2000 • 8,260 citations

Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain

2001 • 2,768 citations

Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins

2001 • 2,746 citations

Regulation of chromatin structure by site-specific histone H3 methyltransferases

2000 • 2,709 citations

Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer

1999 • 1,865 citations

A Mammalian Histone Deacetylase Related to the Yeast Transcriptional Regulator Rpd3p

1996 • 1,769 citations

Histone Acetyltransferases

2001 • 1,745 citations

Acetylation of Histones and Transcription-Related Factors

2000 • 1,702 citations

Role of Histone H3 Lysine 9 Methylation in Epigenetic Control of Heterochromatin Assembly

2001 • 1,685 citations

Structure and ligand of a histone acetyltransferase bromodomain

1999 • 1,625 citations

Tetrahymena Histone Acetyltransferase A: A Homolog to Yeast Gcn5p Linking Histone Acetylation to Gene Activation

1996 • 1,567 citations

Regulation of Transcription by a Protein Methyltransferase

1999 • 1,169 citations

Histone acetylation and an epigenetic code

2000 • 1,164 citations

ALTERATION OF NUCLEOSOME STRUCTURE AS A MECHANISM OF TRANSCRIPTIONAL REGULATION

1998 • 1,124 citations

A positive role for histone acetylation in transcription factor access to nucleosomal DNA

1993 • 1,116 citations

Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation

1999 • 1,068 citations

Structure and Function of a Human TAF _II 250 Double Bromodomain Module

2000 • 808 citations

Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation

1999 • 806 citations

The Dermatomyositis-Specific Autoantigen Mi2 Is a Component of a Complex Containing Histone Deacetylase and Nucleosome Remodeling Activities

1998 • 791 citations

Synergistic Coupling of Histone H3 Phosphorylation and Acetylation in Response to Epidermal Growth Factor Stimulation

2000 • 782 citations

Chromatin disruption and modification

1999 • 537 citations

The histone tails of the nucleosome

1998 • 512 citations

The structural basis for the recognition of acetylated histone H4 by the bromodomain of histone acetyltransferase Gcn5p

2000 • 508 citations

Conservation of deposition-related acetylation sites in newly synthesized histones H3 and H4.

1995 • 500 citations

Methylation of histone H3 at lysine 4 is highly conserved and correlates with transcriptionally active nuclei in Tetrahymena

1999 • 480 citations

The HP1 protein family: getting a grip on chromatin

2000 • 476 citations

The Occurrence of iε-N-Methyl Lysine in Histones

1964 • 472 citations

Acetylation of histone H4 plays a primary role in enhancing transcription factor binding to nucleosomal DNA in vitro.

1996 • 469 citations

Characterization of nucleosome core particles containing histone proteins made in bacteria 1 1Edited by A. Klug

1997 • 465 citations

Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31

1999 • 433 citations

Studies of the DNA binding properties of histone H4 amino terminus. Thermal denaturation studies reveal that acetylation markedly reduces the binding constant of the H4 “tail” to DNA.

1993 • 423 citations

Histone acetylation reduces nucleosome core particle linking number change

1989 • 394 citations

NuRD and SIN3

2000 • 384 citations

SET domain proteins modulate chromatin domains in eu- and heterochromatin

1998 • 374 citations

Efficient Transcriptional Silencing in Saccharomyces cerevisiae Requires a Heterochromatin Histone Acetylation Pattern

1996 • 363 citations

The Drosophila Fab-7 Chromosomal Element Conveys Epigenetic Inheritance during Mitosis and Meiosis

1998 • 360 citations

Synergistic Enhancement of Nuclear Receptor Function by p160 Coactivators and Two Coactivators with Protein Methyltransferase Activities

2001 • 356 citations

Review: Chromatin Structural Features and Targets That Regulate Transcription

2000 • 348 citations

Nucleosomal DNA regulates the core-histone-binding subunit of the human Hat1 acetyltransferase

1998 • 344 citations

25 years after the nucleosome model: chromatin modifications

2000 • 338 citations

Use of selectively trypsinized nucleosome core particles to analyze the role of the histone “tails” in the stabilization of the nucleosome

1989 • 330 citations

The heterochromatin-associated protein HP-1 is an essential protein in Drosophila with dosage-dependent effects on position-effect variegation.

1992 • 318 citations

Position effect variegation and chromatin proteins

1992 • 311 citations

Role of covalent modifications of histones in regulating gene expression

1999 • 305 citations

Heterochromatin Dynamics in Mouse Cells

1999 • 287 citations

Mammalian chromodomain proteins: their role in genome organisation and expression

2000 • 271 citations

The bromodomain: a chromatin-targeting module?

1999 • 270 citations

Overcoming telomeric silencing: a trans-activator competes to establish gene expression in a cell cycle-dependent way.

1994 • 267 citations

Functional analysis of the chromo domain of HP1.

1995 • 259 citations

Chromosomal Inheritance of Epigenetic States in Fission Yeast During Mitosis and Meiosis

1996 • 258 citations

Histone Acetylation and Chromatin Assembly: A Single Escort, Multiple Dances?

1996 • 249 citations

Position-effect variegation and the new biology of heterochromatin

1994 • 244 citations

Mutations in the fission yeast silencing factors clr4 + and rik1 + disrupt the localisation of the chromo domain protein Swi6p and impair centromere function

1996 • 241 citations

Structure and Function of the Core Histone N-Termini: More Than Meets the Eye

1998 • 241 citations

Heterochromatin and gene regulation in Drosophila

1996 • 226 citations

The histone deacetylase RPD3 counteracts genomic silencing in Drosophila and yeast

1996 • 223 citations

The distribution and turnover of labeled methyl groups in histone fractions of cultured mammalian cells

1972 • 221 citations

Beyond the Nucleosome: Epigenetic Aspects of Position–Effect Variegation in Drosophila

1998 • 221 citations

Chromatin-modifying and -remodeling complexes

1999 • 217 citations

Histone Deacetylase Homologs Regulate Epigenetic Inheritance of Transcriptional Silencing and Chromosome Segregation in Fission Yeast

1998 • 189 citations

Role of protein methylation in chromatin remodeling and transcriptional regulation

2001 • 186 citations

The chromo superfamily: new members, duplication of the chromo domain and possible role in delivering transcription regulators to chromatin

1995 • 182 citations

Histone H4 Acetylation of Euchromatin and Heterochromatin Is Cell Cycle Dependent and Correlated with Replication Rather Than with Transcription

2000 • 172 citations

The Methylation of Histones during Regeneration of the Liver

1968 • 160 citations

Acetylation Increases the α-Helical Content of the Histone Tails of the Nucleosome

2000 • 152 citations

DNA Methylation and Histone Deacetylation in the Control of Gene Expression: Basic Biochemistry to Human Development and Disease

2001 • 150 citations

Studies of Histone Methylation during the HeLa S-3 Cell Cycle

1972 • 138 citations

Down-regulation of HP1Hsalpha expression is associated with the metastatic phenotype in breast cancer.

2000 • 126 citations

The identification of distinct populations of acetylated histone.

1980 • 122 citations

Localization of the sites along nucleosome DNA which interact with NH2-terminal histone regions.

1977 • 119 citations

The Nucleosome: A Powerful Regulator of Transcription

1998 • 109 citations

Heterochromatin

1999 • 102 citations

Heterochromatin polymorphism and human cancer

1981 • 93 citations

Transcriptional silencing in fission yeast

2000 • 82 citations

IN VIVO METHYLATION AND TURNOVER OF RAT BRAIN HISTONES

1974 • 79 citations

Functional Interaction between the Coactivator Drosophila CREB-Binding Protein and ASH1, a Member of the Trithorax Group of Chromatin Modifiers

2000 • 76 citations

Methylation of Drosophila histones at proline, lysine, and arginine residues during heat shock.

1988 • 74 citations

Relationship between Methylation and Acetylation of Arginine-Rich Histones in Cycling and Arrested HeLa Cells

1995 • 69 citations

Propagating epigenetic states through meiosis: where Mendel's gene is more than a DNA moiety

1998 • 65 citations

Methylation of lysine residues of histone fractions in synchronized mommalian cells

1971 • 56 citations

Co-operation between protein-acetylating and protein-methylating co-activators in transcriptional activation

2000 • 55 citations

A Truncated Form of the Human CAF-1 p150 Subunit Impairs the Maintenance of Transcriptional Gene Silencing in Mammalian Cells

2001 • 48 citations

Kinetics of Histone Methylation in vivo and Its Relation to the Cell Cycle in Ehrlich Ascites Tumor Cells

1975 • 42 citations

Dynamically acetylated histones of chicken erythrocytes are selectively methylated

1991 • 39 citations

Distribution of methylated histones and histone methyltransferases in chicken erythrocyte chromatin

1989 • 39 citations

Physical association between the histone acetyl transferase CBP and a histone methyl transferase

2001 • 38 citations

The Periodic Synthesis of S-Adenosylmethionine:Protein Methyltransferases during the HeLa S-3 Cell Cycle

1973 • 36 citations

Signaling to Chromatin through Histone Modifications: How Clear Is the Signal?

1998 • 36 citations

Histone methylation. Its occurrence in different cell types and relation to histone H4 metabolism in developing trout testis.

1975 • 34 citations

Quantitative features of chromatin structure in the prognosis of breast cancer

1990 • 34 citations

In vivo turnover and distribution of radio-N-methyl in arginine-rich histones from rat tissues

1972 • 31 citations

Changes in the methylation pattern of core histones during heat-shock in Drosophila cells.

1982 • 28 citations

Relative Stabilität Lysin-gebundener Methylgruppen bei den argininreichen Histonen und ihren Unterfraktionen von Ehrlich-Ascites-Tumorzellen in vitro

1972 • 26 citations

[Relative stability of lysine-bound methyl groups in arginie-rich histones and their subfrations in Ehrlich ascites tumor cells in vitro].

1972 • 20 citations

Time out: developmental regulation of heterochromatic silencing in Drosophila

1998 • 18 citations

Co-operation between protein-acetylating and protein-methylating co-activators in transcriptional activation

2000 • 16 citations

Intercalating agents as probes of the spatial relationship between chromatin components

1975 • 16 citations

PHOSPHORYLATION AND METHYLATION OF CHROMATIN PROTEINS FROM MOUSE BRAIN NUCLEI

1977 • 11 citations

Acetylation and methylation of histones H3 and H4 in chicken immature erythrocytes are not directly coupled

1992 • 9 citations