The structure of the nuclear hormone receptors

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

Gene regulation by steroid hormones

1989 • 3,466 citations

Molecular basis of agonism and antagonism in the oestrogen receptor

1997 • 3,285 citations

MOLECULAR MECHANISMS OF ACTION OF STEROID/THYROID RECEPTOR SUPERFAMILY MEMBERS

1994 • 2,875 citations

Repetitive zinc-binding domains in the protein transcription factor IIIA from Xenopus oocytes.

1985 • 2,450 citations

Sequence and Characterization of a Coactivator for the Steroid Hormone Receptor Superfamily

1995 • 2,390 citations

A CBP Integrator Complex Mediates Transcriptional Activation and AP-1 Inhibition by Nuclear Receptors

1996 • 2,183 citations

A signature motif in transcriptional co-activators mediates binding to nuclear receptors

1997 • 2,100 citations

STEROID RECEPTOR REGULATED TRANSCRIPTION OF SPECIFIC GENES AND GENE NETWORKS

1985 • 1,911 citations

Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-γ

1998 • 1,902 citations

Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors

1991 • 1,725 citations

Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA

1991 • 1,501 citations

The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function

1997 • 1,300 citations

Characterization of three RXR genes that mediate the action of 9-cis retinoic acid.

1992 • 1,200 citations

Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-α

1995 • 1,179 citations

Transcriptional activation: A complex puzzle with few easy pieces

1994 • 1,112 citations

Crystal structure of the RAR-γ ligand-binding domain bound to all-trans retinoic acid

1995 • 1,085 citations

Nuclear receptors enhance our understanding of transcription regulation

1988 • 1,062 citations

The drosophila EcR gene encodes an ecdysone receptor, a new member of the steroid receptor superfamily

1991 • 958 citations

A structural role for hormone in the thyroid hormone receptor

1995 • 938 citations

Role of CBP/P300 in nuclear receptor signalling

1996 • 935 citations

Functional domains of the human glucocorticoid receptor

1986 • 933 citations

Nuclear receptor coactivators and corepressors.

1996 • 917 citations

Identification of a conserved region required for hormone dependent transcriptional activation by steroid hormone receptors.

1992 • 829 citations

The crystal structure of the estrogen receptor DNA-binding domain bound to DNA: How receptors discriminate between their response elements

1993 • 745 citations

Steroid Hormone Receptors: Interaction with Deoxyribonucleic Acid and Transcription Factors*

1993 • 724 citations

GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors.

1996 • 702 citations

DNA sequences bound specifically by glucocorticoid receptor in vitro render a heterologous promoter hormone responsive in vivo

1983 • 692 citations

Crystallographic comparison of the estrogen and progesterone receptor’s ligand binding domains

1998 • 690 citations

‘Zinc fingers’: a novel protein motif for nucleic acid recognition

1987 • 676 citations

Atomic structure of progesterone complexed with its receptor

1998 • 654 citations

The glucocorticoid receptor binds to defined nucleotide sequences near the promoter of mouse mammary tumour virus

1983 • 619 citations

Solution Structure of the Glucocorticoid Receptor DNA-Binding Domain

1990 • 609 citations

Structural determinants of nuclear receptor assembly on DNA direct repeats

1995 • 561 citations

The function and structure of the metal coordination sites within the glucocorticoid receptor DNA binding domain

1988 • 522 citations

Colocalization of DNA-binding and transcriptional activation functions in the human glucocorticoid receptor

1987 • 512 citations

Solution structure of the DMA-binding domain of the oestrogen receptor

1990 • 458 citations

Folding of immunogenic peptide fragments of proteins in water solution

1988 • 437 citations

Nuclear Receptor-Binding Sites of Coactivators Glucocorticoid Receptor Interacting Protein 1 (GRIP1) and Steroid Receptor Coactivator 1 (SRC-1): Multiple Motifs with Different Binding Specificities

1998 • 417 citations

Nuclear receptor coactivators and corepressors

1996 • 414 citations

The primary structure of transcription factor TFIIIA has 12 consecutive repeats

1985 • 413 citations

Proposed structure for the zinc-binding domains from transcription factor IIIA and related proteins.

1988 • 411 citations

Differential ligand-dependent interactions between the AF-2 activating domain of nuclear receptors and the putative transcriptional intermediary factors mSUG1 and TIF1.

1996 • 410 citations

Biochemistry, Molecular Biology, and Physiology of the Glucocorticoid Receptor*

1987 • 409 citations

Folding of peptide fragments comprising the complete sequence of proteins

1992 • 391 citations

Distinct classes of transcriptional activating domains function by different mechanisms

1990 • 368 citations

Steroid Hormone Receptors

1976 • 345 citations

RARs and RXRs: evidence for two autonomous transactivation functions (AF-1 and AF-2) and heterodimerization in vivo.

1993 • 305 citations

Anatomy of the Steroid Receptor Zinc Finger Region

1992 • 299 citations

Structure of the Retinoid X Receptor α DNA Binding Domain: a Helix Required for Homodimeric DNA Binding

1993 • 296 citations

Analysis of estrogen receptor transcriptional enhancement by a nuclear hormone receptor coactivator.

1996 • 258 citations

Peptide .alpha.-helicity in aqueous trifluoroethanol: correlations with predicted .alpha.-helicity and the secondary structure of the corresponding regions of bovine growth hormone

1990 • 192 citations

A protein that interacts with members of the nuclear hormone receptor family: identification and cDNA cloning.

1995 • 186 citations

Cross-coupling of signal transduction pathways: zinc finger meets leucine zipper

1991 • 177 citations

Identification and Estrogen Induction of Two Estrogen Receptors (ER) Messenger Ribonucleic Acids in the Rainbow Trout Liver: Sequence Homology with other ERs

1989 • 171 citations

Structural characterization of a minimal functional transactivation domain from the human glucocorticoid receptor.

1995 • 160 citations

Structural and functional analysis of the NF-kappa B p65 C terminus. An acidic and modular transactivation domain with the potential to adopt an alpha-helical conformation.

1994 • 158 citations

Cloning of a teleost fish glucocorticoid receptor shows that it contains a deoxyribonucleic acid-binding domain different from that of mammals.

1995 • 157 citations

Evidence for Ligand-Dependent Intramolecular Folding of the AF-2 Domain in Vitamin D Receptor-Activated Transcription and Coactivator Interaction

1997 • 154 citations

Transcriptional coactivators in yeast and beyond

1995 • 146 citations

Conformational adaptation of agonists to the human nuclear receptor RARγ

1998 • 140 citations

Solution structure of a zinc finger domain of yeast ADR1

1990 • 115 citations

Characterization of Receptor Interaction and Transcriptional Repression by the Corepressor SMRT

1997 • 112 citations

Estrogen Response Elements Function as Allosteric Modulators of Estrogen Receptor Conformation

1998 • 110 citations

Functional Interaction of the c-Myc Transactivation Domain with the TATA Binding Protein: Evidence for an Induced Fit Model of Transactivation Domain Folding

1996 • 109 citations

Cross-coupling of signal transduction pathways: zinc finger meets leucine zipper

1991 • 106 citations

Refined solution structure of the glucocorticoid receptor DNA-binding domain

1993 • 98 citations

Purification and characterization of the carboxyl-terminal transactivation domain of Vmw65 from herpes simplex virus type 1.

1992 • 93 citations

Nuclear Receptor-Binding Sites of Coactivators Glucocorticoid Receptor Interacting Protein 1 (GRIP1) and Steroid Receptor Coactivator 1 (SRC-1): Multiple Motifs with Different Binding Specificities

1998 • 93 citations

Cloning of a teleost fish glucocorticoid receptor shows that it contains a deoxyribonucleic acid-binding domain different from that of mammals

1995 • 87 citations

Involvement of the Transcription Factor IID Protein Complex in Gene Activation by the N-Terminal Transactivation Domain of the Glucocorticoid Receptorin Vitro

1997 • 85 citations

Role of the Ada Adaptor Complex in Gene Activation by the Glucocorticoid Receptor

1997 • 74 citations

Direct interaction of the tau 1 transactivation domain of the human glucocorticoid receptor with the basal transcriptional machinery.

1993 • 63 citations

A comparison of ¹⁵N NMR relaxation measurements with a molecular dynamics simulation: Backbone dynamics of the glucocorticoid receptor DNA‐binding domain

1993 • 54 citations

The solution structure of the human retinoic acid receptor-β DNA-binding domain

1993 • 53 citations

Backbone dynamics of the glucocorticoid receptor DNA-binding domain

1992 • 48 citations

Dissection of progesterone receptor-mediated chromatin remodeling and transcriptional activation in vivo.

1995 • 45 citations

Characterization of Receptor Interaction and Transcriptional Repression by the Corepressor SMRT

1997 • 36 citations

1 Physiology of the steroid—thyroid hormone nuclear receptor superfamily

1994 • 34 citations

Evidence for Ligand-Dependent Intramolecular Folding of the AF-2 Domain in Vitamin D Receptor-Activated Transcription and Coactivator Interaction

1997 • 31 citations

Activation Function 1 of Retinoic Acid Receptor β2 Is an Acidic Activator Resembling VP16

1995 • 23 citations

Interrelationships between Nuclear Structure and Ligand-Activated Intracellular Receptors

1996 • 16 citations

Involvement of the Transcription Factor IID Protein Complex in Gene Activation by the N-Terminal Transactivation Domain of the Glucocorticoid Receptor in Vitro

1997 • 15 citations

Two transcription activation functions in the amino terminus of the mouse estrogen receptor that are affected by the carboxy terminus

1997 • 15 citations

Steroid Hormone Receptors

2007 • 9 citations