Regulation of the Dynamics of hsp90 Action on the Glucocorticoid Receptor by Acetylation/Deacetylation of the Chaperone

HDAC6 is a microtubule-associated deacetylase

2002 • 2,214 citations

Aggresomes, inclusion bodies and protein aggregation

2000 • 1,881 citations

Regulation of Signaling Protein Function and Trafficking by the hsp90/hsp70-Based Chaperone Machinery

2003 • 1,470 citations

Nuclear protein CBP is a coactivator for the transcription factor CREB

1994 • 1,447 citations

The Deacetylase HDAC6 Regulates Aggresome Formation and Cell Viability in Response to Misfolded Protein Stress

2003 • 1,447 citations

Crystal Structure of an Hsp90–Geldanamycin Complex: Targeting of a Protein Chaperone by an Antitumor Agent

1997 • 1,345 citations

Identification and Structural Characterization of the ATP/ADP-Binding Site in the Hsp90 Molecular Chaperone

1997 • 1,235 citations

HDAC6 Regulates Hsp90 Acetylation and Chaperone-Dependent Activation of Glucocorticoid Receptor

2005 • 1,074 citations

Heat shock protein 90 as a molecular target for cancer therapeutics

2003 • 572 citations

The Amino-terminal Domain of Heat Shock Protein 90 (hsp90) That Binds Geldanamycin Is an ATP/ADP Switch Domain That Regulates hsp90 Conformation

1997 • 554 citations

Histone deacetylase inhibitors as new cancer drugs

2001 • 533 citations

The Heat Shock Protein 90 Antagonist Novobiocin Interacts with a Previously Unrecognized ATP-binding Domain in the Carboxyl Terminus of the Chaperone

2000 • 494 citations

Pharmacologic shifting of a balance between protein refolding and degradation mediated by Hsp90

1996 • 406 citations

Perturbation of Hsp90 interaction with nascent CFTR prevents its maturation and accelerates its degradation by the proteasome

1998 • 367 citations

Modulation of p53, ErbB1, ErbB2, and Raf-1 Expression in Lung Cancer Cells by Depsipeptide FR901228

2002 • 367 citations

p53 is associated with cellular microtubules and is transported to the nucleus by dynein

2000 • 352 citations

Role of hsp90 and the hsp90-binding immunophilins in signalling protein movement

2004 • 280 citations

Folding of the Glucocorticoid Receptor by the Heat Shock Protein (hsp) 90-based Chaperone Machinery

1997 • 260 citations

Stable and specific binding of heat shock protein 90 by geldanamycin disrupts glucocorticoid receptor function in intact cells.

1996 • 259 citations

Nucleotides and Two Functional States of hsp90

1997 • 238 citations

The Importance of ATP Binding and Hydrolysis by Hsp90 in Formation and Function of Protein Heterocomplexes

1999 • 224 citations

Histone deacetylase as a new target for cancer chemotherapy

2001 • 214 citations

A Nucleotide-dependent Molecular Switch Controls ATP Binding at the C-terminal Domain of Hsp90

2002 • 207 citations

Folding of the Glucocorticoid Receptor by the Reconstituted hsp90-based Chaperone Machinery

1997 • 183 citations

Stepwise Assembly of a Glucocorticoid Receptor·hsp90 Heterocomplex Resolves Two Sequential ATP-dependent Events Involving First hsp70 and Then hsp90 in Opening of the Steroid Binding Pocket

2000 • 168 citations

Neuronal Nitric-oxide Synthase Is Regulated by the hsp90-based Chaperone System in Vivo

1999 • 161 citations

Hsp90-binding Immunophilins Link p53 to Dynein During p53 Transport to the Nucleus

2004 • 150 citations

Binding of ATP to Heat Shock Protein 90

2002 • 134 citations

Evidence for Glucocorticoid Receptor Transport on Microtubules by Dynein

2004 • 131 citations

p23, a simple protein with complex activities

2003 • 113 citations

The Influence of ATP and p23 on the Conformation of hsp90

2002 • 103 citations

The Hsp90 Cochaperone p23 Is the Limiting Component of the Multiprotein Hsp90/Hsp70-based Chaperone System in Vivo Where It Acts to Stabilize the Client Protein·Hsp90 Complex

2003 • 94 citations

In vivo electron paramagnetic resonance oximetry with particulate materials

2003 • 65 citations

Binding of hsp90 to the Glucocorticoid Receptor Requires a Specific 7-Amino Acid Sequence at the Amino Terminus of the Hormone-binding Domain

1998 • 54 citations

Mutations at Positions 547–553 of Rat Glucocorticoid Receptors Reveal That hsp90 Binding Requires the Presence, but Not Defined Composition, of a Seven-amino Acid Sequence at the Amino Terminus of the Ligand Binding Domain

2002 • 37 citations

The Role of hsp90 in Heme-dependent Activation of Apo-neuronal Nitric-oxide Synthase

2004 • 37 citations

Regulation of Glucocorticoid Receptor Ligand-Binding Activity by the hsp90/hsp70-based Chaperone Machinery

2003 • 25 citations