Transactivation Functions of the N-Terminal Domains of Nuclear Hormone Receptors: Protein Folding and Coactivator Interactions

Living with Water Stress: Evolution of Osmolyte Systems

1982 • 3,735 citations

Molecular basis of agonism and antagonism in the oestrogen receptor

1997 • 3,285 citations

MOLECULAR MECHANISMS OF ACTION OF STEROID/THYROID RECEPTOR SUPERFAMILY MEMBERS

1994 • 2,875 citations

The coregulator exchange in transcriptional functions of nuclear receptors

2000 • 2,219 citations

A CBP Integrator Complex Mediates Transcriptional Activation and AP-1 Inhibition by Nuclear Receptors

1996 • 2,183 citations

Why are ?natively unfolded? proteins unstructured under physiologic conditions?

2000 • 2,020 citations

Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-γ

1998 • 1,902 citations

Nuclear Receptor Coregulators: Cellular and Molecular Biology*

1999 • 1,783 citations

Nuclear Receptor Coactivator ACTR Is a Novel Histone Acetyltransferase and Forms a Multimeric Activation Complex with P/CAF and CBP/p300

1997 • 1,472 citations

Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-α

1995 • 1,179 citations

Crystal structure of the RAR-γ ligand-binding domain bound to all-trans retinoic acid

1995 • 1,085 citations

The role of general initiation factors in transcription by RNA polymerase II

1996 • 1,001 citations

Experimental and Theoretical Aspects of Protein Folding

1975 • 965 citations

A structural role for hormone in the thyroid hormone receptor

1995 • 938 citations

Functional domains of the human glucocorticoid receptor

1986 • 933 citations

Nuclear receptor coactivators and corepressors.

1996 • 917 citations

A Steroid Receptor Coactivator, SRA, Functions as an RNA and Is Present in an SRC-1 Complex

1999 • 788 citations

GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors.

1996 • 702 citations

Crystallographic comparison of the estrogen and progesterone receptor’s ligand binding domains

1998 • 690 citations

Atomic structure of progesterone complexed with its receptor

1998 • 654 citations

The role of general initiation factors in transcription by RNA polymerase II

1996 • 653 citations

Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARα

2002 • 588 citations

Connections and Regulation of the Human Estrogen Receptor

2002 • 570 citations

Structural studies of p21Waf1/Cip1/Sdi1 in the free and Cdk2-bound state: conformational disorder mediates binding diversity.

1996 • 562 citations

Colocalization of DNA-binding and transcriptional activation functions in the human glucocorticoid receptor

1987 • 512 citations

Is protein folding hierarchic? I. Local structure and peptide folding

1999 • 493 citations

Isoform-specific amino-terminal domains dictate DNA-binding properties of ROR alpha, a novel family of orphan hormone nuclear receptors.

1994 • 485 citations

Critical Structural Elements of the VP16 Transcriptional Activation Domain

1991 • 461 citations

The Peptide Backbone Plays a Dominant Role in Protein Stabilization by Naturally Occurring Osmolytes

1995 • 450 citations

Acid blobs and negative noodles

1988 • 438 citations

FXXLF and WXXLF Sequences Mediate the NH2-terminal Interaction with the Ligand Binding Domain of the Androgen Receptor

2000 • 431 citations

The N-terminal region of the chicken progesterone receptor specifies target gene activation

1988 • 425 citations

Folding transition in the DMA-binding domain of GCN4 on specific binding to DNA

1990 • 378 citations

Nuclear Hormone Receptor Coregulators In Action: Diversity For Shared Tasks

2000 • 377 citations

Interaction between the Amino- and Carboxyl-terminal Regions of the Rat Androgen Receptor Modulates Transcriptional Activity and Is Influenced by Nuclear Receptor Coactivators

1997 • 370 citations

Estrogen Receptor Activation Function 1 Works by Binding p160 Coactivator Proteins

1998 • 366 citations

Steroid hormone receptors and their regulation by phosphorylation

1996 • 361 citations

Forcing Thermodynamically Unfolded Proteins to Fold

1998 • 357 citations

Activation Function 2 in the Human Androgen Receptor Ligand Binding Domain Mediates Interdomain Communication with the NH2-terminal Domain

1999 • 354 citations

Interdomain communication regulating ligand binding by PPAR-γ

1998 • 344 citations

Local Structural Elements in the Mostly Unstructured Transcriptional Activation Domain of Human p53

2000 • 330 citations

Structural and functional characterization of the short acidic transcriptional activation region of yeast GCN4 protein

1988 • 325 citations

Accommodating protein flexibility in computational drug design.

2000 • 321 citations

Identification of two transactlvation domains in the mouse oestrogen receptor

1989 • 303 citations

The contribution of the N- and C-terminal regions of steroid receptors to activation of transcription is both receptor and cell-specific

1989 • 299 citations

Osmolyte-driven contraction of a random coil protein

1998 • 283 citations

Differential regulation of glucocorticoid receptor transcriptional activation via AF-1-associated proteins

1999 • 274 citations

A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor α coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA

2001 • 269 citations

The Androgen Receptor Amino-Terminal Domain Plays a Key Role in p160 Coactivator-Stimulated Gene Transcription

1999 • 268 citations

Pattern of aromatic and hydrophobic amino acids critical for one of two subdomains of the VP16 transcriptional activator.

1993 • 261 citations

Glucocorticoid Receptor Mutants That Define a Small Region Sufficient for Enhancer Activation

1987 • 260 citations

Allosteric Regulation of Estrogen Receptor Structure, Function, and Coactivator Recruitment by Different Estrogen Response Elements

2002 • 236 citations

Hormone-Dependent Interaction between the Amino- and Carboxyl-Terminal Domains of Progesterone Receptor in Vitro and in Vivo

1999 • 167 citations

Trimethylamine N-Oxide-induced Cooperative Folding of an Intrinsically Unfolded Transcription-activating Fragment of Human Glucocorticoid Receptor

1999 • 167 citations

Distinct steady–state nuclear receptor coregulator complexes exist in vivo

1998 • 165 citations

Structural characterization of a minimal functional transactivation domain from the human glucocorticoid receptor.

1995 • 160 citations

Dependence of Selective Gene Activation on the Androgen Receptor NH2- and COOH-terminal Interaction

2002 • 159 citations

Structural and functional analysis of the NF-kappa B p65 C terminus. An acidic and modular transactivation domain with the potential to adopt an alpha-helical conformation.

1994 • 158 citations

p300 Mediates Functional Synergism between AF-1 and AF-2 of Estrogen Receptor α and β by Interacting Directly with the N-terminal A/B Domains

2000 • 154 citations

Synergism Between ERα Transactivation Function 1 (AF-1) and AF-2 Mediated by Steroid Receptor Coactivator Protein-1: Requirement for the AF-1 α-Helical Core and for a Direct Interaction Between the N- and C-Terminal Domains

2001 • 154 citations

The acidic activation domains of the GCN4 and GAL4 proteins are not α helical but form β sheets

1993 • 151 citations

Synergy between estrogen receptor α activation functions AF1 and AF2 mediated by transcription intermediary factor TIF2

2000 • 145 citations

An N-terminal Inhibitory Function, IF, Suppresses Transcription by the A-isoform but Not the B-isoform of Human Progesterone Receptors

1998 • 145 citations

Protein Stabilization by Naturally Occurring Osmolytes

2003 • 144 citations

Conformational Analysis of the Androgen Receptor Amino-terminal Domain Involved in Transactivation

2002 • 143 citations

Transcriptional coregulators of the nuclear receptor superfamily: coactivators and corepressors

2001 • 139 citations

Genetic evidence that an activation domain of GAL4 does not require acidity and may form a β sheet

1993 • 138 citations

The Conformation of the Glucocorticoid Receptor AF1/tau1 Domain Induced by Osmolyte Binds Co-regulatory Proteins

2001 • 134 citations

The N-terminal Regions of Estrogen Receptor α and β Are Unstructured in Vitro and Show Different TBP Binding Properties

2001 • 133 citations

Trimethylamine-N-Oxide Counteracts Urea Effects on Rabbit Muscle Lactate Dehydrogenase Function: A Test of the Counteraction Hypothesis

1998 • 131 citations

Three Amino Acid Substitutions Selectively Disrupt the Activation but Not the Repression Function of the Glucocorticoid Receptor N Terminus

1997 • 116 citations

Functional Interaction of the c-Myc Transactivation Domain with the TATA Binding Protein: Evidence for an Induced Fit Model of Transactivation Domain Folding

1996 • 109 citations

Role of Acidic and Phosphorylated Residues in Gene Activation by the Glucocorticoid Receptor

1995 • 107 citations

Interdomain Signaling in a Two-domain Fragment of the Human Glucocorticoid Receptor

1999 • 102 citations

Delineation of a small region within the majortransactivation domain of the human glucocorticoid receptor that mediatestransactivation of gene expression.

1994 • 98 citations

Purification and characterization of the carboxyl-terminal transactivation domain of Vmw65 from herpes simplex virus type 1.

1992 • 93 citations

The N-terminal Region of the Human Progesterone A-receptor

2000 • 90 citations

Transcriptional Activation Domain of the Herpesvirus Protein VP16 Becomes Conformationally Constrained upon Interaction with Basal Transcription Factors

1996 • 89 citations

Involvement of the Transcription Factor IID Protein Complex in Gene Activation by the N-Terminal Transactivation Domain of the Glucocorticoid Receptorin Vitro

1997 • 85 citations

Role of Important Hydrophobic Amino Acids in the Interaction between the Glucocorticoid Receptor τ1-Core Activation Domain and Target Factors

1998 • 78 citations

Role of the Ada Adaptor Complex in Gene Activation by the Glucocorticoid Receptor

1997 • 74 citations

Role of Hydrophobic Amino Acid Clusters in the Transactivation Activity of the Human Glucocorticoid Receptor

1997 • 67 citations

The N-terminal Region of Human Progesterone B-receptors

2001 • 66 citations

A mouse model to test the in vivo efficacy of chemical chaperones

1998 • 55 citations

Function of N-Terminal Transactivation Domain of the Estrogen Receptor Requires a Potential α-Helical Structure and Is Negatively Regulated by the A Domain

2000 • 47 citations

Cortisol resistance and the guinea pig glucocorticoid receptor

1995 • 44 citations

The Androgen Receptor (AR) Amino-Terminus Imposes Androgen-Specific Regulation of AR Gene Expression via an Exonic Enhancer*

2001 • 42 citations

Structural and functional properties of the N transcriptional activation domain of thyroid transcription factor-1: similarities with the acidic activation domains

1998 • 36 citations

Architectural Principles for the Structure and Function of the Glucocorticoid Receptor τ1 Core Activation Domain

2000 • 30 citations

Thermodynamic propensities of amino acids in the native state ensemble: Implications for fold recognition

2001 • 27 citations

TIF2 Mediates the Synergy between RARα1 Activation Functions AF-1 and AF-2

2002 • 27 citations

Activation Function 1 of Retinoic Acid Receptor β2 Is an Acidic Activator Resembling VP16

1995 • 23 citations

Identification and Characterization of the AF-1 Transactivation Domain of Thyroid Hormone Receptor β1

1997 • 22 citations

Modeling the Native State Ensemble

2003 • 22 citations

Peroxisomal bifunctional enzyme binds and activates the activationfunction-1 region of the peroxisome proliferator-activated receptor α

2001 • 21 citations

Differential gene induction by glucocorticoid and progesterone receptors

1998 • 17 citations

Two transcription activation functions in the amino terminus of the mouse estrogen receptor that are affected by the carboxy terminus

1997 • 15 citations

Homology modelling of the ligand-binding domain of glucocorticoid receptor: binding site interactions with cortisol and corticosterone

2001 • 14 citations

Peroxisomal bifunctional enzyme binds and activates the activationfunction-1 region of the peroxisome proliferator-activated receptor α

2001 • 13 citations