Mechanisms of glucocorticoid receptor signaling during inflammation

Mitogen-Activated Protein Kinase Pathways Mediated by ERK, JNK, and p38 Protein Kinases

2002 • 4,097 citations

Missing Pieces in the NF-κB Puzzle

2002 • 3,560 citations

AP-1 in cell proliferation and survival

2001 • 1,686 citations

Anti-inflammatory Actions of Glucocorticoids: Molecular Mechanisms

1998 • 1,516 citations

Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor

1990 • 1,272 citations

Acetylation: a regulatory modification to rival phosphorylation?

2000 • 1,136 citations

Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation.

1995 • 926 citations

NF-κB as a Therapeutic Target in Multiple Myeloma

2002 • 906 citations

The Interplay between the Glucocorticoid Receptor and Nuclear Factor-κB or Activator Protein-1: Molecular Mechanisms for Gene Repression

2003 • 871 citations

CREB-binding protein/p300 are transcriptional coactivators of p65

1997 • 819 citations

Molecular Control of Immune/Inflammatory Responses: Interactions Between Nuclear Factor-κB and Steroid Receptor-Signaling Pathways

1999 • 785 citations

Cooperativity of glucocorticoid response elements located far upstream of the tyrosine aminotransferase gene

1987 • 760 citations

Functional interactions between Stat5 and the glucocorticoid receptor

1996 • 681 citations

The glucocorticoid receptor inhibits NFκB by interfering with serine-2 phosphorylation of the RNA polymerase II carboxy-terminal domain

2000 • 550 citations

Functional selectivity of recombinant mammalian SWI/SNF subunits

2000 • 503 citations

Glucocorticoids inhibit MAP kinase via increased expression and decreased degradation of MKP-1

2001 • 466 citations

Proinflammatory cytokines regulate human glucocorticoid receptor gene expression and lead to the accumulation of the dominant negative β isoform: A mechanism for the generation of glucocorticoid resistance

2001 • 460 citations

NF-κB Binds P-TEFb to Stimulate Transcriptional Elongation by RNA Polymerase II

2001 • 431 citations

The structure of the nuclear hormone receptors

1999 • 414 citations

Association of Glucocorticoid Insensitivity with Increased Expression of Glucocorticoid Receptor β

1997 • 413 citations

p38 Mitogen-activated protein kinase–induced glucocorticoid receptor phosphorylation reduces its activity: Role in steroid-insensitive asthma

2002 • 410 citations

Cross-Talk between Nuclear Factor-κB and the Steroid Hormone Receptors: Mechanisms of Mutual Antagonism

1998 • 405 citations

Dexamethasone Causes Sustained Expression of Mitogen-Activated Protein Kinase (MAPK) Phosphatase 1 and Phosphatase-Mediated Inhibition of MAPK p38

2002 • 369 citations

Nuclear hormone receptor antagonism with AP-1 by inhibition of the JNK pathway

1997 • 337 citations

Glucocorticoids repress NF-κB-driven genes by disturbing the interaction of p65 with the basal transcription machinery, irrespective of coactivator levels in the cell

2000 • 319 citations

Nuclear Integration of Glucocorticoid Receptor and Nuclear Factor-κB Signaling by CREB-binding Protein and Steroid Receptor Coactivator-1

1998 • 307 citations

Folding of the Glucocorticoid Receptor by the Heat Shock Protein (hsp) 90-based Chaperone Machinery

1997 • 260 citations

Expression of glucocorticoid receptor β in lymphocytes of patients with glucocorticoid-resistant ulcerative colitis

2000 • 251 citations

STAT3 Acts as a Co-activator of Glucocorticoid Receptor Signaling

1997 • 236 citations

How many nuclear hormone receptors are there in the human genome?

2001 • 231 citations

Clinical significance of P-glycoprotein in multidrug resistance malignancies [editorial] [see comments]

1993 • 231 citations

Glucocorticoid resistance in inflammatory bowel disease

2003 • 229 citations

Transactivation Functions of the N-Terminal Domains of Nuclear Hormone Receptors: Protein Folding and Coactivator Interactions

2003 • 202 citations

Mice with an Increased Glucocorticoid Receptor Gene Dosage Show Enhanced Resistance to Stress and Endotoxic Shock

2000 • 202 citations

Transcriptional Hyperactivity of Human Progesterone Receptors Is Coupled to Their Ligand-Dependent Down-Regulation by Mitogen-Activated Protein Kinase-Dependent Phosphorylation of Serine 294

2001 • 198 citations

SHP2 Mediates the Protective Effect of Interleukin-6 against Dexamethasone-induced Apoptosis in Multiple Myeloma Cells

2000 • 189 citations

Molecular mechanisms of glucocorticoid antiproliferative effects: antagonism of transcription factor activity by glucocorticoid receptor

2002 • 189 citations

Specific DNA Binding of Stat5, but Not of Glucocorticoid Receptor, Is Required for Their Functional Cooperation in the Regulation of Gene Transcription

1997 • 184 citations

Clinical significance of P-glycoprotein in multidrug resistance malignancies [editorial] [see comments]

1993 • 172 citations

Glucocorticoid receptor inhibits transforming growth factor-β signaling by directly targeting the transcriptional activation function of Smad3

1999 • 169 citations

Glucocorticoids and Tumor Necrosis Factor Alpha Cooperatively Regulate Toll-Like Receptor 2 Gene Expression

2004 • 168 citations

The Role of DnaJ-like Proteins in Glucocorticoid Receptor·hsp90 Heterocomplex Assembly by the Reconstituted hsp90·p60·hsp70 Foldosome Complex

1998 • 168 citations

CBP (CREB Binding Protein) Integrates NF-κB (Nuclear Factor-κB) and Glucocorticoid Receptor Physical Interactions and Antagonism

2000 • 167 citations

Glucocorticoids Synergistically Enhance NontypeableHaemophilus influenzae-induced Toll-like Receptor 2 Expression via a Negative Cross-talk with p38 MAP Kinase

2002 • 153 citations

Molecular Identification and Characterization of A and B Forms of the Glucocorticoid Receptor

2001 • 148 citations

Involvement of Histone Methylation and Phosphorylation in Regulation of Transcription by Thyroid Hormone Receptor

2002 • 138 citations

Insertion of an Amino Acid in the DNA-Binding Domain of the Glucocorticoid Receptor as a Result of Alternative Splicing

1999 • 129 citations

Comparison of the Transactivation Domains of Stat5 and Stat6 in Lymphoid Cells and Mammary Epithelial Cells

1997 • 126 citations

Glucocorticoid receptor-JNK interaction mediates inhibition of the JNK pathway by glucocorticoids

2003 • 124 citations

Cytoplasmic catalytic subunit of protein kinase A mediates cross-repression by NF-κB and the glucocorticoid receptor

2000 • 124 citations

Glucocorticoid Receptor/Signal Transducer and Activator of Transcription 5 (STAT5) Interactions Enhance STAT5 Activation by Prolonging STAT5 DNA Binding and Tyrosine Phosphorylation

1999 • 123 citations

Expression in Hematological Malignancies of a Glucocorticoid Receptor Splice Variant That Augments Glucocorticoid Receptor-mediated Effects in Transfected Cells

2001 • 115 citations

Transcriptional Control Mechanism of Fibrinogen Gene Expression

2001 • 105 citations

Critical role of nuclear factor‐κB and stress‐activated protein kinases in steroid unresponsiveness

2002 • 105 citations

Mapping of Glucocorticoid Receptor DNA Binding Domain Surfaces Contributing to Transrepression of NF-κB and Induction of Apoptosis

2001 • 96 citations

Glucocorticoid Repression of AP-1 Is Not Mediated by Competition for Nuclear Coactivators

2001 • 93 citations

Structure and Dynamic Properties of a Glucocorticoid Receptor-Induced Chromatin Transition

2000 • 90 citations

Role of the negative glucocorticoid regulatory element in glucocorticoid repression of the human osteocalcin promoter

1993 • 88 citations

Mechanisms of Corticosteroid Resistance in Rheumatoid Arthritis

2002 • 87 citations

Crosstalk between the interleukin-6 (IL-6)-JAK-STAT and the glucocorticoid-nuclear receptor pathway: synergistic activation of IL-6 response element by IL-6 and glucocorticoid

1998 • 86 citations

Cooperation Among Stat1, Glucocorticoid Receptor, and PU.1 in Transcriptional Activation of the High-Affinity Fcγ Receptor I in Monocytes

2000 • 85 citations

A Weak TATA Box Is a Prerequisite for Glucocorticoid-dependent Repression of the Osteocalcin Gene

1997 • 79 citations

Hormone activation induces nucleosome positioning in vivo

2000 • 70 citations

Interleukin-2 Inhibits Glucocorticoid Receptor Transcriptional Activity through a Mechanism Involving STAT5 (Signal Transducer and Activator of Transcription 5) but Not AP-1

2001 • 68 citations

Glucocorticoid Receptor Counteracts Tumorigenic Activity of Akt in Skin through Interference with the Phosphatidylinositol 3-Kinase Signaling Pathway

2003 • 68 citations

Resistance to glucocorticoid-induced apoptosis in lymphoblastic leukemia

2003 • 61 citations

A Necessary Good: Nuclear Hormone Receptors and Their Chromatin Templates

2001 • 59 citations

Glucocorticoids Inhibit Calcium- and Calcineurin-Dependent Activation of the Human IL-4 Promoter

2000 • 59 citations

The Pursuit of Differentiated Ligands for the Glucocorticoid Receptor

2003 • 53 citations

Regulation of the human interleukin-2 gene by the α and β isoforms of the glucocorticoid receptor1This manuscript is dedicated to Prof. Dr F.A. Leidenberger on the occasion of his 60th birthday.1

1997 • 49 citations

Repression of p65 Transcriptional Activation by the Glucocorticoid Receptor in the Absence of Receptor-Coactivator Interactions

2003 • 28 citations

Role of TATA-element in transcription from glucocorticoid receptor-responsive model promoters

1990 • 24 citations

Transforming Growth Factor β Enhances the Glucocorticoid Response of the Mouse Mammary Tumor Virus Promoter through Smad and GA-Binding Proteins

2004 • 18 citations

Glucocorticoid Resistance in Thymocytes from Mice Expressing a T Cell Receptor Transgene

2000 • 15 citations