The Sonic hedgehog gradient in the developing limb

Positional information and the spatial pattern of cellular differentiation

1969 • 2,957 citations

Hedgehog signaling in animal development: paradigms and principles

2001 • 2,919 citations

Sonic hedgehog mediates the polarizing activity of the ZPA

1993 • 2,313 citations

Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity

1993 • 2,146 citations

The primary cilium: a signalling centre during vertebrate development

2010 • 1,738 citations

Cholesterol Modification of Hedgehog Signaling Proteins in Animal Development

1996 • 1,342 citations

Epithelial-Mesenchymal Interactions

1967 • 1,218 citations

Evidence for an Expansion-Based Temporal Shh Gradient in Specifying Vertebrate Digit Identities

2004 • 970 citations

Sonic hedgehog and Fgf-4 act through a signaling cascade and feedback loop to integrate growth and patterning of the developing limb bud

1994 • 801 citations

Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein

1999 • 772 citations

Identification of a Palmitic Acid-modified Form of Human Sonic hedgehog

1998 • 735 citations

Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network

2008 • 714 citations

Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation

2000 • 704 citations

A positive feedback loop coordinates growth and patterning in the vertebrate limb

1994 • 702 citations

Local application of retinoic acid to the limb bond mimics the action of the polarizing region

1982 • 669 citations

FGF-4 replaces the apical ectodermal ridge and directs outgrowth and patterning of the limb

1993 • 660 citations

Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity

2002 • 591 citations

Morphogen Gradients: From Generation to Interpretation

2011 • 588 citations

Genetic Analysis of the Roles of BMP2, BMP4, and BMP7 in Limb Patterning and Skeletogenesis

2006 • 588 citations

Positional signalling and specification of digits in chick limb morphogenesis

1975 • 588 citations

Hox10 and Hox11 Genes Are Required to Globally Pattern the Mammalian Skeleton

2003 • 562 citations

GLI3 zinc-finger gene interrupted by translocations in Greig syndrome families

1991 • 549 citations

Cholesterol Modification of Sonic Hedgehog Is Required for Long-Range Signaling Activity and Effective Modulation of Signaling by Ptc1

2001 • 514 citations

Sonic hedgehog Signaling Regulates Gli2 Transcriptional Activity by Suppressing Its Processing and Degradation

2006 • 507 citations

Dynamic Changes in the Response of Cells to Positive Hedgehog Signaling during Mouse Limb Patterning

2004 • 498 citations

A freely diffusible form of Sonic hedgehog mediates long-range signalling

2001 • 485 citations

Bone morphogenetic proteins and a signalling pathway that controls patterning in the developing chick limb

1994 • 465 citations

Signal relay by BMP antagonism controls the SHH/FGF4 feedback loop in vertebrate limb buds

1999 • 455 citations

Disruption of a long-range cis-acting regulator for Shh causes preaxial polydactyly

2002 • 445 citations

Vertebrate limb bud development: moving towards integrative analysis of organogenesis

2009 • 444 citations

Manifestation of the Limb Prepattern: Limb Development in the Absence of Sonic Hedgehog Function

2001 • 437 citations

Progression of Vertebrate Limb Development Through SHH-Mediated Counteraction of GLI3

2002 • 381 citations

A quantitative analysis of the effect of excision of the AER from the chick limb-bud

1974 • 376 citations

Elimination of a long-range cis-regulatory module causes complete loss of limb-specificShhexpression and truncation of the mouse limb

2005 • 375 citations

Appendage Regeneration in Adult Vertebrates and Implications for Regenerative Medicine

2005 • 365 citations

Genetic evidence that FGFs have an instructive role in limb proximal–distal patterning

2008 • 362 citations

Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates

2004 • 360 citations

A Comprehensive Collection of Chicken cDNAs

2002 • 331 citations

Control of Vertebrate Limb Outgrowth by the Proximal Factor Meis2 and Distal Antagonism of BMPs by Gremlin

1999 • 317 citations

Opposing RA and FGF signals control proximodistal vertebrate limb development through regulation of Meis genes

2000 • 314 citations

Relationship between dose, distance and time in Sonic Hedgehog-mediated regulation of anteroposterior polarity in the chick limb

1997 • 314 citations

Developmental basis of evolutionary digit loss in the Australian lizard Hemiergis

2003 • 307 citations

A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb

2008 • 294 citations

Uncoupling Sonic Hedgehog Control of Pattern and Expansion of the Developing Limb Bud

2008 • 289 citations

The Whereabouts of a Morphogen: Direct Evidence for Short- and Graded Long-Range Activity of Hedgehog Signaling Peptides

2001 • 288 citations

Overlapping Roles and Collective Requirement for the Coreceptors GAS1, CDO, and BOC in SHH Pathway Function

2011 • 277 citations

The Hedgehog-binding proteins Gas1 and Cdo cooperate to positively regulate Shh signaling during mouse development

2007 • 272 citations

Interdigital Regulation of Digit Identity and Homeotic Transformation by Modulated BMP Signaling

2000 • 266 citations

Distinct Roles of Hand2 in Initiating Polarity and Posterior Shh Expression during the Onset of Mouse Limb Bud Development

2010 • 257 citations

Retinoic acid induces polarizing activity but is unlikely to be a morphogen in the chick limb bud

1991 • 242 citations

Notochord-derived Shh concentrates in close association with the apically positioned basal body in neural target cells and forms a dynamic gradient during neural patterning

2008 • 239 citations

Conversion by retinoic acid of anterior cells into ZPA cells in the chick wing bud

1991 • 218 citations

A model for anteroposterior patterning of the vertebrate limb based on sequential long- and short-range Shh signalling and Bmp signalling

2000 • 217 citations

The number of polarizing region cells required to specify additional digits in the developing chick wing

1981 • 209 citations

Gas1 extends the range of Hedgehog action by facilitating its signaling

2007 • 207 citations

Integration of growth and specification in chick wing digit-patterning

2008 • 206 citations

The Role of Spatially Controlled Cell Proliferation in Limb Bud Morphogenesis

2010 • 191 citations

A Self-Regulatory System of Interlinked Signaling Feedback Loops Controls Mouse Limb Patterning

2009 • 191 citations

Mouse Dispatched homolog1 Is Required for Long-Range, but Not Juxtacrine, Hh Signaling

2002 • 185 citations

Cholesterol modification restricts the spread of Shh gradient in the limb bud

2006 • 182 citations

Limb-patterning activity and restricted posterior localization of the amino-terminal product of Sonic hedgehog cleavage

1995 • 176 citations

Point mutations in a distant sonic hedgehog cis-regulator generate a variable regulatory output responsible for preaxial polydactyly

2007 • 174 citations

Cell fate in the chick limb bud and relationship to gene expression

1997 • 167 citations

Cerebellar proteoglycans regulate sonic hedgehog responses during development

2002 • 155 citations

Vertebrate limb development

1995 • 154 citations

FGF-4 maintains polarizing activity of posterior limb bud cells in vivo and in vitro

1993 • 151 citations

Direct and continuous assessment by cells of their position in a morphogen gradient

1995 • 150 citations

Modeling ciliopathies: Primary cilia in development and disease.

2008 • 150 citations

Opposing Functions of the ETS Factor Family Define Shh Spatial Expression in Limb Buds and Underlie Polydactyly

2012 • 146 citations

Unique SMAD1/5/8 activity at the phalanx-forming region determines digit identity

2008 • 144 citations

Developmental morphology of limb reduction in hemiergis (squamata: scincidae): chondrogenesis, osteogenesis, and heterochrony

2002 • 142 citations

Making digit patterns in the vertebrate limb

2005 • 140 citations

Tbx Genes Specify Posterior Digit Identity through Shh and BMP Signaling

2004 • 140 citations

Extended exposure to Sonic hedgehog is required for patterning the posterior digits of the vertebrate limb

2007 • 131 citations

TheTalpid3gene (KIAA0586) encodes a centrosomal protein that is essential for primary cilia formation

2009 • 127 citations

Space-dependent cell determination under the control of a morphogen gradient

1978 • 127 citations

The chickoligozeugodactyly(ozd) mutant lacks sonic hedgehog function in the limb

2003 • 127 citations

A specific mutation in the distant sonic hedgehog (SHH)cis-regulator (ZRS) causes Werner mesomelic syndrome (WMS) while complete ZRS duplications underlie Haas type polysyndactyly and preaxial polydactyly (PPD) with or without triphalangeal thumb

2009 • 125 citations

The chicken talpid³ gene encodesa novel protein essentialfor Hedgehog signaling

2006 • 121 citations

Spatiotemporal distribution of mechanisms that control outgrowth and anteroposterior polarization of the limb bud in the chick embryo

1973 • 114 citations

SHH propagates distal limb bud development by enhancing CYP26B1-mediated retinoic acid clearance via AER-FGF signalling

2011 • 110 citations

Identification of Sonic hedgehog as a candidate gene responsible for the polydactylous mouse mutant Sasquatch

1999 • 106 citations

Chapter 5 Modeling Ciliopathies

2008 • 103 citations

The Shh-independent activator function of the full-length Gli3 protein and its role in vertebrate limb digit patterning

2007 • 103 citations

Acheiropodia Is Caused by a Genomic Deletion in C7orf2, the Human Orthologue of the Lmbr1 Gene

2001 • 99 citations

Polydactyly: How many disorders and how many genes? 2010 update

2011 • 87 citations

A variant in the sonic hedgehog regulatory sequence (ZRS) is associated with triphalangeal thumb and deregulates expression in the developing limb

2008 • 81 citations

Cell cycle and experimental pattern duplication in the chick wing during embryonic development

1980 • 80 citations

Insights into bird wing evolution and digit specification from polarizing region fate maps

2011 • 75 citations

Maps of strength of positional signalling activity in the developing chick wing bud.

1985 • 75 citations

Generation of mice with functional inactivation oftalpid3, a gene first identified in chicken

2011 • 73 citations

Gradients of signalling in the developing limb

2011 • 72 citations

Transcriptomic analysis of avian digits reveals conserved and derived digit identities in birds

2011 • 69 citations

Embryological Evidence Identifies Wing Digits in Birds as Digits 1, 2, and 3

2011 • 66 citations

Short- and long-range effects of Sonic hedgehog in limb development

2003 • 64 citations

Pattern formation along the anteroposterior axis of the chick wing: the increase in width following a polarizing region graft and the effect of X-irradiation

1981 • 63 citations

Attenuation of positional signalling in the chick limb by high doses of γ-radiation

1978 • 58 citations

Distinctive Expression Patterns of Heparan Sulfate O-Sulfotransferases and Regional Differences in Heparan Sulfate Structure in Chick Limb Buds

2004 • 58 citations

Positional signal transmission in the developing chick limb

1981 • 55 citations

The proximo-distal sequence of origin of the parts of the chick wing and the role of the ectoderm

1998 • 54 citations

The chicken polydactyly (Po) locus causes allelic imbalance and ectopic expression of Shh during limb development

2011 • 46 citations

A scanning electron microscope study of the early limb-bud in normal andtalpid3mutant chick embryos

1974 • 43 citations

The time required for positional signalling in the chick wing bud

1980 • 43 citations

Identification of spontaneous mutations within the long‐range limb‐specific Sonic hedgehog enhancer (ZRS) that alter Sonic hedgehog expression in the chicken limb mutants oligozeugodactyly and silkie breed

2011 • 36 citations

Manipulations of PKA in chick limb development reveal roles in digit patterning including a positive role in Sonic Hedgehog signaling

2007 • 32 citations

Aberrant FGF signaling, independent of ectopic hedgehog signaling, initiates preaxial polydactyly in Dorking chickens

2009 • 23 citations

Identification of genes downstream of the Shh signalling in the developing chick wing and syn-expressed with Hoxd13 using microarray and 3D computational analysis

2010 • 18 citations

Comparative Analysis of 3D Expression Patterns of Transcription Factor Genes and Digit Fate Maps in the Developing Chick Wing

2011 • 16 citations

When ATPases Pontin and Reptin Met Telomerase

2008 • 14 citations

Grafting of Apical Ridge and Polarizing Region

2008 • 2 citations