Overlapping Roles and Collective Requirement for the Coreceptors GAS1, CDO, and BOC in SHH Pathway Function

Hedgehog signalling in the mouse requires intraflagellar transport proteins

2003 • 1,377 citations

Activating Smoothened mutations in sporadic basal-cell carcinoma

1998 • 1,327 citations

In situ hybridization; a practical approach

1993 • 1,247 citations

The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog

1996 • 1,106 citations

Pax6 Controls Progenitor Cell Identity and Neuronal Fate in Response to Graded Shh Signaling

1997 • 1,019 citations

1 Developmental roles and clinical significance of Hedgehog signaling

2003 • 896 citations

Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord

1994 • 869 citations

Two Critical Periods of Sonic Hedgehog Signaling Required for the Specification of Motor Neuron Identity

1996 • 866 citations

Biochemical evidence that Patched is the Hedgehog receptor

1996 • 852 citations

Teratogen-Mediated Inhibition of Target Tissue Response to Shh Signaling

1998 • 839 citations

Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein

1999 • 772 citations

Sonic hedgehog signaling is essential for hair development

1998 • 742 citations

The teratogenic Veratrum alkaloid cyclopamine inhibits Sonic hedgehog signal transduction

1998 • 647 citations

Coordinate Regulation of Motor Neuron Subtype Identity and Pan-Neuronal Properties by the bHLH Repressor Olig2

2001 • 614 citations

Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development

1997 • 606 citations

Interpretation of the sonic hedgehog morphogen gradient by a temporal adaptation mechanism

2007 • 602 citations

In situ hybridization; a practical approach

1993 • 599 citations

Smoothened Mutants Reveal Redundant Roles for Shh and Ihh Signaling Including Regulation of L/R Asymmetry by the Mouse Node

2001 • 599 citations

Specification of neuronal fates in the ventral neural tube

2001 • 530 citations

Identification of Hedgehog Pathway Components by RNAi in Drosophila Cultured Cells

2003 • 518 citations

Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system

1998 • 497 citations

A Hox Regulatory Network Establishes Motor Neuron Pool Identity and Target-Muscle Connectivity

2005 • 459 citations

Glial specification in the vertebrate neural tube

2004 • 412 citations

The Cell Surface Membrane Proteins Cdo and Boc Are Components and Targets of the Hedgehog Signaling Pathway and Feedback Network in Mice

2006 • 383 citations

Variations of cervical vertebrate after expression of a Hox-1.1 transgene in mice

1990 • 371 citations

Motor neuron columnar fate imposed by sequential phases of Hox-c activity

2003 • 371 citations

The role of Pax-1 in axial skeleton development

1994 • 343 citations

A Requirement for Retinoic Acid-Mediated Transcriptional Activation in Ventral Neural Patterning and Motor Neuron Specification

2003 • 340 citations

Glypican-3 Inhibits Hedgehog Signaling during Development by Competing with Patched for Hedgehog Binding

2008 • 330 citations

Feedback control of mammalian Hedgehog signaling by the Hedgehog-binding protein, Hip1, modulates Fgf signaling during branching morphogenesis of the lung

2003 • 298 citations

Boc is a receptor for sonic hedgehog in the guidance of commissural axons

2006 • 289 citations

Characterization of two patched receptors for the vertebrate hedgehog protein family

1998 • 281 citations

The Hedgehog-binding proteins Gas1 and Cdo cooperate to positively regulate Shh signaling during mouse development

2007 • 272 citations

Cdo Functions at Multiple Points in the Sonic Hedgehog Pathway, and Cdo-Deficient Mice Accurately Model Human Holoprosencephaly

2006 • 252 citations

Boc and Gas1 Each Form Distinct Shh Receptor Complexes with Ptch1 and Are Required for Shh-Mediated Cell Proliferation

2011 • 234 citations

The Ihog Cell-Surface Proteins Bind Hedgehog and Mediate Pathway Activation

2006 • 230 citations

Growth and pattern of the mammalian neural tube are governed by partially overlapping feedback activities of the hedgehog antagonists patched 1 and Hhip1

2004 • 223 citations

Olig gene function in CNS development and disease

2006 • 215 citations

Gas1 extends the range of Hedgehog action by facilitating its signaling

2007 • 207 citations

Interactions between Hedgehog proteins and their binding partners come into view

2010 • 204 citations

Megalin Functions as an Endocytic Sonic Hedgehog Receptor

2002 • 198 citations

Dynamic Assignment and Maintenance of Positional Identity in the Ventral Neural Tube by the Morphogen Sonic Hedgehog

2010 • 197 citations

Evidence that the WNT-inducible growth arrest-specific gene 1 encodes an antagonist of sonic hedgehog signaling in the somite

2001 • 171 citations

Drosophila Perlecan modulates FGF and Hedgehog signals to activate neural stem cell division

2003 • 166 citations

Vitronectin regulates Sonic hedgehog activity during cerebellum development through CREB phosphorylation

2001 • 164 citations

The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla

2008 • 158 citations

The Drosophila Ortholog of the Human Wnt Inhibitor Factor Shifted Controls the Diffusion of Lipid-Modified Hedgehog

2005 • 124 citations

Genetic and biochemical definition of the Hedgehog receptor

2010 • 123 citations

Shifted, the Drosophila Ortholog of Wnt Inhibitory Factor-1, Controls the Distribution and Movement of Hedgehog

2005 • 120 citations

The Zebrafish-Secreted Matrix Protein You/Scube2 Is Implicated in Long-Range Regulation of Hedgehog Signaling

2005 • 118 citations

Scube2 mediates Hedgehog signalling in the zebrafish embryo

2006 • 112 citations

Microform Holoprosencephaly in Mice that Lack the Ig Superfamily Member Cdon

2003 • 108 citations

The you Gene Encodes an EGF-CUB Protein Essential for Hedgehog Signaling in Zebrafish

2005 • 106 citations

Structure of a heparin-dependent complex of Hedgehog and Ihog

2006 • 90 citations

Sonic hedgehog synergizes with the extracellular matrix protein Vitronectin to induce spinal motor neuron differentiation

2000 • 89 citations

Evolution of the GDNF Family Ligands and Receptors

2006 • 88 citations

Dally-like core protein and its mammalian homologues mediate stimulatory and inhibitory effects on Hedgehog signal response

2010 • 82 citations

Bocmodifies the holoprosencephaly spectrum ofCdomutant mice

2010 • 69 citations

Evidence for a role of vertebrate Disp1 in long-range Shh signaling

2009 • 66 citations

The growth suppressing gas1 product is a GPI‐linked protein

2000 • 64 citations

The Role of Gas1 in Embryonic Development and its Implications for Human Disease

2007 • 61 citations

Gas1 Is Related to the Glial Cell-derived Neurotrophic Factor Family Receptors α and Regulates Ret Signaling

2006 • 61 citations

Megalin and the neurodevelopmental biology of sonic hedgehog and retinol

2003 • 59 citations

Vitronectin is expressed in the ventral region of the neural tube and promotes the differentiation of motor neurons

1997 • 57 citations

Is GAS1 a co-receptor for the GDNF family of ligands?

2006 • 54 citations

Ihog and Boi are essential for Hedgehog signaling in Drosophila

2010 • 52 citations

Beyond the cell surface: New mechanisms of receptor function

2010 • 40 citations

Specific requirements of sonic hedgehog signaling during oligodendrocyte development

2005 • 38 citations

Loss of neurturin in frog—Comparative genomics study of GDNF family ligand-receptor pairs

2006 • 30 citations

Shh and Gli3 activities are required for timely generation of motor neuron progenitors

2009 • 23 citations