Extended exposure to Sonic hedgehog is required for patterning the posterior digits of the vertebrate limb

A series of normal stages in the development of the chick embryo

1951 • 12,226 citations

Hedgehog signaling in animal development: paradigms and principles

2001 • 2,919 citations

Sonic hedgehog mediates the polarizing activity of the ZPA

1993 • 2,313 citations

Hedgehog-Regulated Processing of Gli3 Produces an Anterior/Posterior Repressor Gradient in the Developing Vertebrate Limb

2000 • 1,019 citations

Evidence for an Expansion-Based Temporal Shh Gradient in Specifying Vertebrate Digit Identities

2004 • 970 citations

Expression of Cre recombinase in the developing mouse limb bud driven by a Prxl enhancer

2002 • 943 citations

Teratogen-Mediated Inhibition of Target Tissue Response to Shh Signaling

1998 • 839 citations

Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog.

1996 • 829 citations

Sonic hedgehog and Fgf-4 act through a signaling cascade and feedback loop to integrate growth and patterning of the developing limb bud

1994 • 801 citations

A positive feedback loop coordinates growth and patterning in the vertebrate limb

1994 • 702 citations

The teratogenic Veratrum alkaloid cyclopamine inhibits Sonic hedgehog signal transduction

1998 • 647 citations

Differential staining of cartilage and bone in whole mouse fetuses by alcian blue and alizarin red S

1980 • 618 citations

Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity

2002 • 591 citations

Sonic Hedgehog-induced Activation of the Gli1Promoter Is Mediated by GLI3

1999 • 528 citations

Cholesterol Modification of Sonic Hedgehog Is Required for Long-Range Signaling Activity and Effective Modulation of Signaling by Ptc1

2001 • 514 citations

Dynamic Changes in the Response of Cells to Positive Hedgehog Signaling during Mouse Limb Patterning

2004 • 498 citations

All Mouse Ventral Spinal Cord Patterning by Hedgehog Is Gli Dependent and Involves an Activator Function of Gli3

2004 • 440 citations

Manifestation of the Limb Prepattern: Limb Development in the Absence of Sonic Hedgehog Function

2001 • 437 citations

Sonic hedgehog Differentially Regulates Expression ofGLIandGLI3during Limb Development

1996 • 385 citations

Progression of Vertebrate Limb Development Through SHH-Mediated Counteraction of GLI3

2002 • 381 citations

Gremlin is the BMP antagonist required for maintenance of Shh and Fgf signals during limb patterning

2003 • 367 citations

Gremlin-mediated BMP antagonism induces the epithelial-mesenchymal feedback signaling controlling metanephric kidney and limb organogenesis

2004 • 355 citations

Relationship between dose, distance and time in Sonic Hedgehog-mediated regulation of anteroposterior polarity in the chick limb

1997 • 314 citations

Conservation in hedgehog signaling: induction of a chicken patched homolog by Sonic hedgehog in the developing limb

1996 • 298 citations

A Dual Role for Hox Genes in Limb Anterior-Posterior Asymmetry

2004 • 272 citations

Mutual genetic antagonism involving GLI3 and dHAND prepatterns the vertebrate limb bud mesenchyme prior to SHH signaling

2002 • 237 citations

Some distal limb structures develop in mice lacking Sonic hedgehog signaling

2001 • 226 citations

Expression of the vertebrate Gli proteins in Drosophila reveals a distribution of activator and repressor activities

2000 • 217 citations

The number of polarizing region cells required to specify additional digits in the developing chick wing

1981 • 209 citations

Analysis of Hoxd-13 and Hoxd-11 misexpression in chick limb buds reveals that Hox genes affect both bone condensation and growth

1997 • 208 citations

Cholesterol modification restricts the spread of Shh gradient in the limb bud

2006 • 182 citations

Control of dorsoventral pattern in the chick paraxial mesoderm

1997 • 168 citations

Cell fate in the chick limb bud and relationship to gene expression

1997 • 167 citations

Size dependence during the development of the amphibian foot. Colchicine-induced digital loss and reduction

1983 • 163 citations

Vertebrate limb development

1995 • 154 citations

The chickoligozeugodactyly(ozd) mutant lacks sonic hedgehog function in the limb

2003 • 127 citations

Autoregulation ofShhexpression and Shh induction of cell death suggest a mechanism for modulating polarising activity during chick limb development

2000 • 110 citations

Zebrafish Gli3 functions as both an activator and a repressor in Hedgehog signaling

2004 • 101 citations

Differential regulation of gene expression in the digit forming area of the mouse limb bud by SHH and gremlin 1/FGF-mediated epithelial-mesenchymal signalling

2006 • 98 citations

The timing of ossification of the limb bones, and growth rates of various long bones of the fore and hind limbs of the prenatal and early postnatal laboratory mouse.

1995 • 96 citations

Conditional inactivation of Fgfr1 in mouse defines its role in limb bud establishment, outgrowth and digit patterning

2005 • 92 citations

Ptc1 and Ptc2 Transcripts Provide Distinct Readouts of Hedgehog Signaling Activity during Chick Embryogenesis

2001 • 85 citations

Distinct and regulated activities of human Gli proteins in Drosophila

1999 • 58 citations

Similar expression and regulation of Gli2 and Gli3 in the chick limb bud

2000 • 35 citations