Distinctive Expression Patterns of Heparan Sulfate O-Sulfotransferases and Regional Differences in Heparan Sulfate Structure in Chick Limb Buds

Functions of Cell Surface Heparan Sulfate Proteoglycans

1999 • 2,660 citations

Fgf10 is essential for limb and lung formation

1999 • 1,204 citations

The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo

1995 • 1,175 citations

Crystal Structure of a Ternary FGF-FGFR-Heparin Complex Reveals a Dual Role for Heparin in FGFR Binding and Dimerization

2000 • 1,146 citations

[22] Detection of messenger RNA by in Situ hybridization to tissue sections and whole mounts

1993 • 807 citations

Heparin Structure and Interactions with Basic Fibroblast Growth Factor

1996 • 789 citations

Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin

2000 • 679 citations

Perlecan Maintains the Integrity of Cartilage and Some Basement Membranes

1999 • 665 citations

The roles of FGFs in the early development of vertebrate limbs

1998 • 659 citations

Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction

1998 • 555 citations

Release of basic fibroblast growth factor-heparan sulfate complexes from endothelial cells by plasminogen activator-mediated proteolytic activity.

1990 • 545 citations

Activating and inhibitory heparin sequences for FGF-2 (basic FGF). Distinct requirements for FGF-1, FGF-2, and FGF-4.

1993 • 542 citations

Perlecan is essential for cartilage and cephalic development

1999 • 536 citations

The mesenchymal factor, FGF10, initiates and maintains the outgrowth of the chick limb bud through interaction with FGF8, an apical ectodermal factor

1997 • 529 citations

An Essential Heparin-Binding Domain in the Fibroblast Growth Factor Receptor Kinase

1993 • 520 citations

Identification of the basic fibroblast growth factor binding sequence in fibroblast heparan sulfate.

1992 • 511 citations

Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion

1998 • 505 citations

Regulation of growth factor activation by proteoglycans: What is the role of the low affinity receptors?

1995 • 478 citations

Renal agenesis in mice homozygous for a gene trap mutation in the gene encoding heparan sulfate 2-sulfotransferase

1998 • 453 citations

Minimal sequence in heparin/heparan sulfate required for binding of basic fibroblast growth factor.

1993 • 449 citations

Disruption of Gastrulation and Heparan Sulfate Biosynthesis in EXT1-Deficient Mice

2000 • 408 citations

Crystal Structures of Two FGF-FGFR Complexes Reveal the Determinants of Ligand-Receptor Specificity

2000 • 401 citations

FGF-4 and BMP-2 have opposite effects on limb growth

1993 • 377 citations

A quantitative analysis of the effect of excision of the AER from the chick limb-bud

1974 • 376 citations

Hedgehog Movement Is Regulated through tout velu–Dependent Synthesis of a Heparan Sulfate Proteoglycan

1999 • 367 citations

Interaction of hepatocyte growth factor with heparan sulfate. Elucidation of the major heparan sulfate structural determinants

1994 • 316 citations

Glycosaminoglycans can modulate extracellular localization of the wingless protein and promote signal transduction.

1996 • 307 citations

Structural Analysis of Glycosaminoglycans inDrosophila and Caenorhabditis elegans and Demonstration That tout-velu, a Drosophila Gene Related to EXT Tumor Suppressors, Affects Heparan Sulfate in Vivo

2000 • 287 citations

Heparan Sulfate Oligosaccharides Require 6-O-Sulfation for Promotion of Basic Fibroblast Growth Factor Mitogenic Activity

1998 • 276 citations

Deciphering skeletal patterning: clues from the limb

2003 • 257 citations

dally, a Drosophila glypican, controls cellular responses to the TGF-β-related morphogen, Dpp

1997 • 241 citations

Defective Heparan Sulfate Biosynthesis and Neonatal Lethality in Mice LackingN-Deacetylase/N-Sulfotransferase-1

2000 • 239 citations

BMPs negatively regulate structure and function of the limb apical ectodermal ridge

1999 • 232 citations

The Occurrence of Three Isoforms of Heparan Sulfate 6-O-Sulfotransferase Having Different Specificities for Hexuronic Acid Adjacent to the TargetedN-Sulfoglucosamine

2000 • 223 citations

Heparan sulfate: lessons from knockout mice

2001 • 192 citations

Glypican-3 Modulates BMP- and FGF-Mediated Effects during Renal Branching Morphogenesis

2001 • 179 citations

glypican-3 Controls Cellular Responses to Bmp4 in Limb Patterning and Skeletal Development

2000 • 174 citations

Structure of a heparan sulphate oligosaccharide that binds to basic fibroblast growth factor

1992 • 173 citations

Involvement of Androgen-Induced Growth Factor (FGF-8) Gene in Mouse Embryogenesis and Morphogenesis

1994 • 170 citations

Hyperplastic Conotruncal Endocardial Cushions and Transposition of Great Arteries in Perlecan-Null Mice

2002 • 170 citations

cDNA cloning of PG-M, a large chondroitin sulfate proteoglycan expressed during chondrogenesis in chick limb buds. Alternative spliced multiforms of PG-M and their relationships to versican

1993 • 169 citations

Targeted disruption of NDST‐1 gene leads to pulmonary hypoplasia and neonatal respiratory distress in mice

2000 • 166 citations

Ectodermal-mesodermal interactions in the growth of limb buds in the chick embryo: Constancy and temporal limits of the ectodermal induction

1972 • 163 citations

Heparan sulfate: lessons from knockout mice

2001 • 159 citations

FGF-4 maintains polarizing activity of posterior limb bud cells in vivo and in vitro

1993 • 151 citations

Heparan sulfate fine structure and specificity of proteoglycan functions

2002 • 149 citations

Role of heparan sulfate as a tissue-specific regulator of FGF-4 and FGF receptor recognition

2001 • 145 citations

Distribution of FGF‐2 suggests it has a role in chick limb bud growth

1993 • 144 citations

An Animal Cell Mutant Defective in Heparan Sulfate Hexuronic Acid 2- -Sulfation

1996 • 132 citations

Molecular Cloning and Expression of Chinese Hamster Ovary Cell Heparan-sulfate 2-Sulfotransferase

1997 • 122 citations

Drosophila Heparan Sulfate 6-O-Sulfotransferase (dHS6ST) Gene

2001 • 121 citations

Chemotactic migration of mesencephalic neural crest cells in the mouse

2000 • 120 citations

Characterization of Heparan Sulfate Oligosaccharides That Bind to Hepatocyte Growth Factor

1995 • 114 citations

Differential binding of fibroblast growth factor-2 and -7 to basement membrane heparan sulfate: comparison of normal and abnormal human tissues.

1997 • 104 citations

Specific heparan sulfate structures involved in retinal axon targeting

2002 • 103 citations

Vertebrate limb development — the early stages in chick and mouse

2001 • 103 citations

Spatial and temporal patterns of cell death in limb bud mesoderm after apical ectodermal ridge removal

1982 • 102 citations

Molecular Characterization and Expression of Heparan-sulfate 6-Sulfotransferase

1998 • 101 citations

Biosynthesis of Heparin/Heparan Sulfate

1997 • 96 citations

Biosynthesis of heparan sulphate with diverse structures and functions: two alternatively spliced forms of human heparan sulphate 6-O-sulphotransferase-2 having different expression patterns and properties

2003 • 94 citations

Localization of HstI transcripts to the apical ectodermal ridge in the mouse embryo

1992 • 91 citations

Importance of 6-0-Sulfate Groups of Glucosamine Residues in Heparin for Activation of FGF-1 and FGF-2

1995 • 89 citations

Medial Golgi but Not Late Golgi Glycosyltransferases Exist as High Molecular Weight Complexes

2000 • 87 citations

Windbeutel is required for function and correct subcellular localization of the Drosophila patterning protein Pipe

2000 • 67 citations

Cloning, Golgi Localization, and Enzyme Activity of the Full-length Heparin/Heparan Sulfate-Glucuronic Acid C5-epimerase

2001 • 64 citations

A role of Lys⁶¹⁴ in the sulfotransferase activity of human heparan sulfate N‐deacetylase/N‐sulfotransferase

1998 • 55 citations

Formation of Insoluble Oligomers Correlates with ST6Gal I Stable Localization in the Golgi

2000 • 51 citations

FGF-Stimulated Outgrowth and Proliferation of Limb Mesoderm Is Dependent on Syndecan-3

1997 • 48 citations

Antagonists Go out on a Limb

1999 • 48 citations

Preparation and high-performance liquid chromatography of 3′-phosphoadenosine-5′-phospho[35S]sulfate with a predetermined specific activity

1985 • 36 citations

FGFR2 signaling in normal andlimbless chick limb buds

1999 • 22 citations

Molecular Cloning and Characterization of Chick Sialoprotein Associated with Cones and Rods, a Developmentally Regulated Glycoprotein of Interphotoreceptor Matrix

2002 • 15 citations

Community Learning by Radio and the Internet

2002 • 14 citations

Inhibition of Polarizing Activity in the Anterior Limb Bud Is Regulated by Extracellular Factors

2001 • 14 citations

Basic fibroblast growth factor-heparan sulphate complex in the human dialysis-related amyloidosis

1995 • 5 citations