Cholesterol Modification of Sonic Hedgehog Is Required for Long-Range Signaling Activity and Effective Modulation of Signaling by Ptc1

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

1996 • 3,041 citations

Sonic hedgehog mediates the polarizing activity of the ZPA

1993 • 2,313 citations

Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity

1993 • 2,146 citations

Altered Neural Cell Fates and Medulloblastoma in Mouse patched Mutants

1997 • 1,695 citations

Cholesterol Modification of Hedgehog Signaling Proteins in Animal Development

1996 • 1,342 citations

Epithelial-Mesenchymal Interactions

1967 • 1,218 citations

The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog

1996 • 1,106 citations

Hedgehog-Regulated Processing of Gli3 Produces an Anterior/Posterior Repressor Gradient in the Developing Vertebrate Limb

2000 • 1,019 citations

Dual Roles for Patched in Sequestering and Transducing Hedgehog

1996 • 889 citations

In situ Hybridization

1994 • 875 citations

Biochemical evidence that Patched is the Hedgehog receptor

1996 • 852 citations

Compartment boundaries and the control of Drosopfiffa limb pattern by hedgehog protein

1994 • 842 citations

Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog.

1996 • 829 citations

Sonic hedgehog and Fgf-4 act through a signaling cascade and feedback loop to integrate growth and patterning of the developing limb bud

1994 • 801 citations

Sonic hedgehog regulates growth and morphogenesis of the tooth

2000 • 778 citations

Sonic hedgehog signaling is essential for hair development

1998 • 742 citations

Identification of a Palmitic Acid-modified Form of Human Sonic hedgehog

1998 • 735 citations

A positive feedback loop coordinates growth and patterning in the vertebrate limb

1994 • 702 citations

Bone morphogenetic proteins in development

2004 • 678 citations

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Targeted disruption of Fgf8 causes failure of cell migration in the gastrulating mouse embryo

1999 • 644 citations

Sonic hedgehog regulates branching morphogenesis in the mammalian lung

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Gli1 is a target of Sonic hedgehog that induces ventral neural tube development

1997 • 625 citations

Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs

1994 • 624 citations

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Positional signalling and specification of digits in chick limb morphogenesis

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Chapter 11 In Situ Hybridization Analysis of Chick Embryos in Whole Mount and Tissue Sections

1996 • 584 citations

Dispatched, a Novel Sterol-Sensing Domain Protein Dedicated to the Release of Cholesterol-Modified Hedgehog from Signaling Cells

1999 • 571 citations

Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus

1998 • 561 citations

The world according to bedgebog

1997 • 549 citations

Autoproteolysis in hedgehog protein biogenesis

1994 • 541 citations

Hedgehog Patterning Activity: Role of a Lipophilic Modification Mediated by the Carboxy-Terminal Autoprocessing Domain

1996 • 529 citations

Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion

1998 • 505 citations

The product of hedgehog autoproteolytic cleavage active in local and long-range signalling

1995 • 505 citations

Essential Role forSonic hedgehogduring Hair Follicle Morphogenesis

1999 • 489 citations

Signal relay by BMP antagonism controls the SHH/FGF4 feedback loop in vertebrate limb buds

1999 • 455 citations

Targeted expression of the signaling molecule decapentaplegic induces pattern duplications and growth alterations in Drosophila wings.

1994 • 451 citations

Indian Hedgehog coordinates endochondral bone growth and morphogenesis via Parathyroid Hormone related-Protein-dependent and -independent pathways

2000 • 449 citations

Transducing Hedgehog: the story so far

1998 • 444 citations

The Drosophila hedgehog gene is expressed specifically in posterior compartment cells and is a target of engrailed regulation.

1992 • 400 citations

Sonic hedgehog Differentially Regulates Expression ofGLIandGLI3during Limb Development

1996 • 385 citations

The putative tumour suppressor EXT1 alters the expression of cell-surface heparan sulfate

1998 • 377 citations

Distribution of Sonic hedgehog peptides in the developing chick and mouse embryo

1995 • 376 citations

Hedgehog Movement Is Regulated through tout velu–Dependent Synthesis of a Heparan Sulfate Proteoglycan

1999 • 367 citations

Regulation of patched by sonic hedgehog in the developing neural tube.

1996 • 331 citations

Association of Sterol- and Glycosylphosphatidylinositol-linked Proteins with Drosophila Raft Lipid Microdomains

1999 • 320 citations

Relationship between dose, distance and time in Sonic Hedgehog-mediated regulation of anteroposterior polarity in the chick limb

1997 • 314 citations

Proteolytic Processing Yields Two Secreted Forms of Sonic hedgehog

1995 • 309 citations

Characterization of two patched receptors for the vertebrate hedgehog protein family

1998 • 281 citations

The bHLH transcription factor dHAND controls Sonic hedgehog expression and establishment of the zone of polarizing activity during limb development

2000 • 246 citations

Some distal limb structures develop in mice lacking Sonic hedgehog signaling

2001 • 226 citations

Proteoglycans and pattern formation: sugar biochemistry meets developmental genetics

2000 • 223 citations

A model for anteroposterior patterning of the vertebrate limb based on sequential long- and short-range Shh signalling and Bmp signalling

2000 • 217 citations

The number of polarizing region cells required to specify additional digits in the developing chick wing

1981 • 209 citations

Evidence for genetic control of Sonic hedgehog by Gli3 in mouse limb development

1997 • 199 citations

Hox genes in digit development and evolution

1999 • 178 citations

Limb-patterning activity and restricted posterior localization of the amino-terminal product of Sonic hedgehog cleavage

1995 • 176 citations

Activation of Fgf-4 and HoxD gene expression by BMP-2 expressing cells in the developing chick limb

1996 • 130 citations

Contrasting distributions of patched and hedgehog proteins in the Drosophila embryo

1993 • 112 citations

Recent advances in hedgehog signalling

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The molecular ZPA

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Attenuation of positional signalling in the chick limb by high doses of γ-radiation

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Positional signal transmission in the developing chick limb

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hedgehog and wing development in Drosophila: a morphogen at work?

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Related membrane domains in proteins of sterol sensing and cell signaling provide a glimpse of treasures still buried within the dynamic realm of intracellular metabolic regulation

1998 • 44 citations

Gli genes and limb development

1999 • 40 citations

Expression and Functional Analysis of Mouse EXT1, a Homolog of the Human Multiple Exostoses Type 1 Gene

1998 • 32 citations

Isolation and Characterization of the Murine Homolog of the Human EXT2 Multiple Exostoses Gene

1997 • 28 citations

Positional information and prepattern in the development of pattern

1989 • 4 citations