A variant in the sonic hedgehog regulatory sequence (ZRS) is associated with triphalangeal thumb and deregulates expression in the developing limb

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

1996 • 3,041 citations

Sonic hedgehog mediates the polarizing activity of the ZPA

1993 • 2,313 citations

A long-range Shh enhancer regulates expression in the developing limb and fin and is associated with preaxial polydactyly

2003 • 1,126 citations

Disruption of a long-range cis-acting regulator for Shh causes preaxial polydactyly

2002 • 445 citations

Manifestation of the Limb Prepattern: Limb Development in the Absence of Sonic Hedgehog Function

2001 • 437 citations

Elimination of a long-range cis-regulatory module causes complete loss of limb-specificShhexpression and truncation of the mouse limb

2005 • 375 citations

Activation of the Receptor Tyrosine Kinase Kit Is Required for the Proliferation of Melanoblasts in the Mouse Embryo

1997 • 317 citations

A duplicated zone of polarizing activity in polydactylous mouse mutants.

1995 • 189 citations

Pbx1/Pbx2requirement for distal limb patterning is mediated by the hierarchical control of Hox gene spatial distribution andShhexpression

2006 • 181 citations

Point mutations in a distant sonic hedgehog cis-regulator generate a variable regulatory output responsible for preaxial polydactyly

2007 • 174 citations

Phylogenetic conservation of a limb-specific, cis -acting regulator of Sonic hedgehog ( Shh )

2004 • 151 citations

Sonic hedgehog function in chondrichthyan fins and the evolution of appendage patterning

2006 • 129 citations

A microduplication of the long range SHH limb regulator (ZRS) is associated with triphalangeal thumb-polysyndactyly syndrome

2008 • 120 citations

Two novel point mutations in the long‐range SHH enhancer in three families with triphalangeal thumb and preaxial polydactyly

2006 • 113 citations

Identification of Sonic hedgehog as a candidate gene responsible for the polydactylous mouse mutant Sasquatch

1999 • 106 citations

Missense Mutations in the Homeodomain of HOXD13 Are Associated with Brachydactyly Types D and E

2003 • 104 citations

A Physical and Transcriptional Map of the Preaxial Polydactyly Locus on Chromosome 7q36

1999 • 69 citations

A series of ENU-induced single-base substitutions in a long-range cis-element altering Sonic hedgehog expression in the developing mouse limb bud

2007 • 62 citations

How to make a zone of polarizing activity: Insights into limb development via the abnormality preaxial polydactyly

2007 • 62 citations

Characterization of a novel ectodermal signaling center regulating Tbx2 and Shh in the vertebrate limb

2006 • 56 citations

Treatment of the Triphalangeal Thumb

1976 • 54 citations

A single C to T transition in intron 5 of LMBR1 gene is associated with triphalangeal thumb-polysyndactyly syndrome in a Chinese family

2007 • 38 citations

Nonsense‐mediated decay and the molecular pathogenesis of mutations in SALL1 and GLI3

2007 • 37 citations