The Shh-independent activator function of the full-length Gli3 protein and its role in vertebrate limb digit patterning

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

1996 • 3,041 citations

Sonic hedgehog mediates the polarizing activity of the ZPA

1993 • 2,313 citations

Manipulating the Mouse Embryo: A Laboratory Manual

2002 • 2,187 citations

In situ hybridization; a practical approach

1993 • 1,247 citations

Hedgehog-Regulated Processing of Gli3 Produces an Anterior/Posterior Repressor Gradient in the Developing Vertebrate Limb

2000 • 1,019 citations

Gli2 and Gli3 Localize to Cilia and Require the Intraflagellar Transport Protein Polaris for Processing and Function

2005 • 886 citations

Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog.

1996 • 829 citations

Cilia and Hedgehog responsiveness in the mouse

2005 • 793 citations

A mouse model of Greig cephalo–polysyndactyly syndrome: the extra–toesJ mutation contains an intragenic deletion of the Gli3 gene

1993 • 715 citations

The PDGFα receptor is required for neural crest cell development and for normal patterning of the somites

1997 • 706 citations

Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation

2000 • 704 citations

Gli2, but notGli1, is required for initial Shh signaling and ectopic activation of the Shh pathway

2002 • 671 citations

The roles of FGFs in the early development of vertebrate limbs

1998 • 659 citations

In situ hybridization; a practical approach

1993 • 599 citations

Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity

2002 • 591 citations

Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors

2005 • 539 citations

Signal relay by BMP antagonism controls the SHH/FGF4 feedback loop in vertebrate limb buds

1999 • 455 citations

All Mouse Ventral Spinal Cord Patterning by Hedgehog Is Gli Dependent and Involves an Activator Function of Gli3

2004 • 440 citations

Manifestation of the Limb Prepattern: Limb Development in the Absence of Sonic Hedgehog Function

2001 • 437 citations

Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli

2005 • 419 citations

Sonic hedgehog Differentially Regulates Expression ofGLIandGLI3during Limb Development

1996 • 385 citations

Progression of Vertebrate Limb Development Through SHH-Mediated Counteraction of GLI3

2002 • 381 citations

Analysis of Fgf8 gene function in vertebrate development.

1997 • 290 citations

Evidence for the direct involvement of βTrCP in Gli3 protein processing

2005 • 258 citations

Multisite Protein Kinase A and Glycogen Synthase Kinase 3β Phosphorylation Leads to Gli3 Ubiquitination by SCF^βTrCP

2006 • 238 citations

Mutual genetic antagonism involving GLI3 and dHAND prepatterns the vertebrate limb bud mesenchyme prior to SHH signaling

2002 • 237 citations

Some distal limb structures develop in mice lacking Sonic hedgehog signaling

2001 • 226 citations

Pallister-Hall syndrome phenotype in mice mutant for Gli3

2002 • 183 citations

Hox genes in digit development and evolution

1999 • 178 citations

Mouse Rab23 regulates Hedgehog signaling from Smoothened to Gli proteins

2005 • 147 citations

Transduction of graded Hedgehog signaling by a combination of Gli2 and Gli3 activator functions in the developing spinal cord

2004 • 124 citations

The chicken talpid³ gene encodesa novel protein essentialfor Hedgehog signaling

2006 • 121 citations

Pax9 and Jagged1 act downstream of Gli3 in vertebrate limb development

2005 • 97 citations

Strike three for GLI3

1997 • 93 citations

High-resolution mapping of the Gli3 mutation Extra-toesJ reveals a 51.5-kb deletion

2002 • 85 citations