Skinny Hedgehog, an Acyltransferase Required for Palmitoylation and Activity of the Hedgehog Signal

Mutations affecting segment number and polarity in Drosophila

1980 • 4,280 citations

Cholesterol Modification of Hedgehog Signaling Proteins in Animal Development

1996 • 1,342 citations

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

2000 • 1,299 citations

Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis

1998 • 1,075 citations

Compartment boundaries and the control of Drosopfiffa limb pattern by hedgehog protein

1994 • 842 citations

Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways

2000 • 832 citations

Identification of a Palmitic Acid-modified Form of Human Sonic hedgehog

1998 • 735 citations

The Autosomal FLP-DFS Technique for Generating Germline Mosaics in Drosophila melanogaster

1996 • 652 citations

Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs

1994 • 624 citations

Dispatched, a Novel Sterol-Sensing Domain Protein Dedicated to the Release of Cholesterol-Modified Hedgehog from Signaling Cells

1999 • 571 citations

Autoproteolysis in hedgehog protein biogenesis

1994 • 541 citations

Hedgehog Patterning Activity: Role of a Lipophilic Modification Mediated by the Carboxy-Terminal Autoprocessing Domain

1996 • 529 citations

The product of hedgehog autoproteolytic cleavage active in local and long-range signalling

1995 • 505 citations

SAP – a putative DNA-binding motif involved in chromosomal organization

2000 • 499 citations

A superfamily of membrane-bound O -acyltransferases with implications for Wnt signaling

2000 • 477 citations

The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing.

1996 • 337 citations

A Hedgehog activity gradient contributes to AP axial patterning of the Drosophila wing

1997 • 300 citations

Nuclear Trafficking of Cubitus interruptus in the Transcriptional Regulation of Hedgehog Target Gene Expression

1999 • 262 citations

Mutations in the segment polarity genes wingless and porcupine impair secretion of the wingless protein.

1993 • 254 citations

The Drosophila segment polarity gene patched interacts with decapentaplegic in wing development.

1994 • 212 citations

Problems and paradigms: Morphogens and pattern formation

1997 • 184 citations

Purification of a Jojoba Embryo Wax Synthase, Cloning of its cDNA, and Production of High Levels of Wax in Seeds of Transgenic Arabidopsis

2000 • 178 citations

P-Element Insertion Alleles of Essential Genes on the Third Chromosome of Drosophila melanogaster Correlation of Physical and Cytogenetic Maps in Chromosomal Region 86E-87F

1997 • 158 citations

Identification of genes required for alpha 2 repression in Saccharomyces cerevisiae.

1995 • 123 citations

An Acylatable Residue of Hedgehog Is Differentially Required in Drosophila and Mouse Limb Development

2001 • 120 citations

N-terminal fatty-acylation of sonic hedgehog enhances the induction of rodent ventral forebrain neurons

2001 • 119 citations

Human Acyl-CoA:Cholesterol Acyltransferase-1 (ACAT-1) Gene Organization and Evidence That the 4.3-Kilobase ACAT-1 mRNA Is Produced from Two Different Chromosomes

1999 • 117 citations

Isolation of a New Melanoma Antigen, MART-2, Containing a Mutated Epitope Recognized by Autologous Tumor-Infiltrating T Lymphocytes

2001 • 70 citations

Genetic analysis of chromosome region 63 of Drosophila melanogaster.

1991 • 28 citations