Structure of a heparin-dependent complex of Hedgehog and Ihog

Mutations affecting segment number and polarity in Drosophila

1980 • 4,280 citations

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

1996 • 3,041 citations

Hedgehog signaling in animal development: paradigms and principles

2001 • 2,919 citations

Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor

1991 • 2,437 citations

The atomic structure of protein-protein recognition sites 1 1Edited by A. R. Fersht

1999 • 1,932 citations

Shape complementarity at protein–protein interfaces

1994 • 1,217 citations

Calculation of Hydrodynamic Properties of Globular Proteins from Their Atomic-Level Structure

2000 • 1,035 citations

Hedgehog signalling in cancer formation and maintenance

2003 • 821 citations

Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo

2002 • 788 citations

Patched acts catalytically to suppress the activity of Smoothened

2002 • 784 citations

Lipoprotein particles are required for Hedgehog and Wingless signalling

2005 • 678 citations

2.0 Å Crystal Structure of a Four-Domain Segment of Human Fibronectin Encompassing the RGD Loop and Synergy Region

1996 • 621 citations

Hedgehog acts as a somatic stem cell factor in the Drosophila ovary

2001 • 542 citations

Identification of Hedgehog Pathway Components by RNAi in Drosophila Cultured Cells

2003 • 518 citations

Structure of a Fibronectin Type III Domain from Tenascin Phased by MAD Analysis of the Selenomethionyl Protein

1992 • 500 citations

A freely diffusible form of Sonic hedgehog mediates long-range signalling

2001 • 485 citations

The Cell Surface Membrane Proteins Cdo and Boc Are Components and Targets of the Hedgehog Signaling Pathway and Feedback Network in Mice

2006 • 383 citations

Heparan sulfate proteoglycans are critical for the organization of the extracellular distribution of Wingless

2001 • 370 citations

Hedgehog Movement Is Regulated through tout velu–Dependent Synthesis of a Heparan Sulfate Proteoglycan

1999 • 367 citations

Novel Lipid Modifications of Secreted Protein Signals

2004 • 319 citations

Structural Analysis of Glycosaminoglycans inDrosophila and Caenorhabditis elegans and Demonstration That tout-velu, a Drosophila Gene Related to EXT Tumor Suppressors, Affects Heparan Sulfate in Vivo

2000 • 287 citations

Nuclear Trafficking of Cubitus interruptus in the Transcriptional Regulation of Hedgehog Target Gene Expression

1999 • 262 citations

Cdo Functions at Multiple Points in the Sonic Hedgehog Pathway, and Cdo-Deficient Mice Accurately Model Human Holoprosencephaly

2006 • 252 citations

Drosophilaglypicans control the cell-to-cell movement of Hedgehog by a dynamin-independent process

2004 • 237 citations

The Ihog Cell-Surface Proteins Bind Hedgehog and Mediate Pathway Activation

2006 • 230 citations

A potential catalytic site revealed by the 1.7-Å crystal structure of the amino-terminal signalling domain of Sonic hedgehog

1995 • 198 citations

Sonic hedgehog protein signals not as a hydrolytic enzyme but as an apparent ligand for Patched

1999 • 178 citations

Crystal Structure of Hemolin: A Horseshoe Shape with Implications for Homophilic Adhesion

1998 • 177 citations

The Crystal Structure of the Ligand Binding Module of Axonin-1/TAG-1 Suggests a Zipper Mechanism for Neural Cell Adhesion

2000 • 169 citations

Targeting Medulloblastoma: Small-Molecule Inhibitors of the Sonic Hedgehog Pathway as Potential Cancer Therapeutics

2005 • 146 citations

BOC, an Ig superfamily member, associates with CDO to positively regulate myogenic differentiation

2002 • 143 citations

The glypican Dally-like is required for Hedgehog signalling in the embryonic epidermis ofDrosophila

2003 • 142 citations

Hedgehog lipid modifications are required for Hedgehog stabilization in the extracellular matrix

2006 • 139 citations

An optimized system for expression and purification of secreted bacterial proteins

2005 • 114 citations

CDO: An Oncogene-, Serum-, and Anchorage-regulated Member of the Ig/Fibronectin Type III Repeat Family

1997 • 90 citations

Heparan sulfate proteoglycans exert positive and negative effects in Shh activity

2005 • 28 citations

Purification, crystallization and preliminary crystallographic studies of a two fibronectin type-III domain segment from chicken tenascin encompassing the heparin- and contactin-binding regions

1999 • 11 citations