Hedgehog signal transduction: recent findings

Hedgehog signaling in animal development: paradigms and principles

2001 • 2,919 citations

Cholesterol Modification of Hedgehog Signaling Proteins in Animal Development

1996 • 1,342 citations

1 Developmental roles and clinical significance of Hedgehog signaling

2003 • 896 citations

Megalin and cubilin: multifunctional endocytic receptors

2002 • 796 citations

Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein

1999 • 772 citations

Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs

1994 • 624 citations

Dispatched, a Novel Sterol-Sensing Domain Protein Dedicated to the Release of Cholesterol-Modified Hedgehog from Signaling Cells

1999 • 571 citations

Cholesterol Modification of Sonic Hedgehog Is Required for Long-Range Signaling Activity and Effective Modulation of Signaling by Ptc1

2001 • 514 citations

Hedgehog Induces Opposite Changes in Turnover and Subcellular Localization of Patched and Smoothened

2000 • 514 citations

Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion

1998 • 505 citations

A freely diffusible form of Sonic hedgehog mediates long-range signalling

2001 • 485 citations

Skinny Hedgehog, an Acyltransferase Required for Palmitoylation and Activity of the Hedgehog Signal

2001 • 462 citations

Proteolysis of the Hedgehog Signaling Effector Cubitus interruptus Requires Phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1

2002 • 381 citations

Hedgehog Elicits Signal Transduction by Means of a Large Complex Containing the Kinesin-Related Protein Costal2

1997 • 371 citations

Rab23 is an essential negative regulator of the mouse Sonic hedgehog signalling pathway

2001 • 368 citations

Hedgehog Movement Is Regulated through tout velu–Dependent Synthesis of a Heparan Sulfate Proteoglycan

1999 • 367 citations

Costal2, a Novel Kinesin-Related Protein in the Hedgehog Signaling Pathway

1997 • 329 citations

Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator

1998 • 303 citations

Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus

2002 • 294 citations

The growth arrest-specific gene, gas1, is involved in growth suppression

1992 • 274 citations

Nuclear Trafficking of Cubitus interruptus in the Transcriptional Regulation of Hedgehog Target Gene Expression

1999 • 262 citations

Suppressor of Fused represses Gli-mediated transcription by recruiting the SAP18-mSin3 corepressor complex

2002 • 215 citations

Megalin Functions as an Endocytic Sonic Hedgehog Receptor

2002 • 198 citations

Suppressor of Fused opposes Hedgehog signal transduction by impeding nuclear accumulation of the activator form of Cubitus interruptus

2000 • 197 citations

Receptor-mediated endocytosis of soluble and membrane-tethered Sonic hedgehog by Patched-1

2000 • 195 citations

Mutations in the sterol-sensing domain of Patched suggest a role for vesicular trafficking in Smoothened regulation

2001 • 191 citations

Mutational analysis of the yeast a-factor transporter STE6, a member of the ATP binding cassette (ABC) protein superfamily.

1991 • 188 citations

patched overexpression alters wing disc size and pattern: transcriptional and post-transcriptional effects on hedgehog targets

1995 • 185 citations

The sterol-sensing domain of Patched protein seems to control Smoothened activity through Patched vesicular trafficking

2001 • 183 citations

Interactions with Costal2 and Suppressor of fused regulate nuclear translocation and activity of Cubitus interruptus

2000 • 180 citations

Protein kinase A antagonizes Hedgehog signaling by regulating both the activator and repressor forms of Cubitus interruptus

1999 • 176 citations

Evidence that the WNT-inducible growth arrest-specific gene 1 encodes an antagonist of sonic hedgehog signaling in the somite

2001 • 171 citations

Enhanced Potency of Human Sonic Hedgehog by Hydrophobic Modification

2001 • 166 citations

In vivo expression of the lacY gene in two segments leads to functional lac permease.

1990 • 164 citations

Sightless has homology to transmembrane acyltransferases and is required to generate active Hedgehog protein

2001 • 162 citations

Proteolysis of Cubitus interruptus in Drosophila requires phosphorylation by Protein Kinase A

1999 • 159 citations

Cerebellar proteoglycans regulate sonic hedgehog responses during development

2002 • 155 citations

Patched represses the Hedgehog signalling pathway by promoting modification of the Smoothened protein

2000 • 141 citations

The Sonic Hedgehog Receptor Patched Associates with Caveolin-1 in Cholesterol-rich Microdomains of the Plasma Membrane

2001 • 139 citations

rasp, a putative transmembrane acyltransferase, is required for Hedgehog signaling

2002 • 134 citations

In Vivo Functions of the Patched Protein

2000 • 128 citations

Vertebrate Homologs of Drosophila Suppressor of Fused Interact with the Gli Family of Transcriptional Regulators

1999 • 127 citations

An Acylatable Residue of Hedgehog Is Differentially Required in Drosophila and Mouse Limb Development

2001 • 120 citations

Distinct roles of Central missing and Dispatched in sending the Hedgehog signal

2001 • 112 citations

Subcellular localization of the segment polarity protein patched suggests an interaction with the wingless reception complex in Drosophila embryos

1994 • 111 citations

Posttranscriptional Regulation of Smoothened Is Part of a Self-Correcting Mechanism in the Hedgehog Signaling System

2000 • 108 citations

Modulation of Hedgehog target gene expression by the Fused serine–threonine kinase in wing imaginal discs

1998 • 102 citations

Gas1-Induced Growth Suppression Requires a Transactivation-Independent p53 Function

1995 • 97 citations

Structure, function, and chromosome mapping of thegrowth-suppressing human homologue of the murine gas1 gene.

1994 • 78 citations

Reconstitution of an active lactose carrier in vivo by simultaneous synthesis of two complementary protein fragments

1990 • 75 citations

Hedgehog-stimulated Phosphorylation of the Kinesin-related Protein Costal2 Is Mediated by the Serine/Threonine Kinase Fused

2002 • 67 citations

The growth suppressing gas1 product is a GPI‐linked protein

2000 • 64 citations

Sonic Hedgehog as a mediator of long‐range signaling*

2002 • 61 citations

Hedgehog signal transduction proteins: contacts of the Fused kinase and Ci transcription factor with the Kinesin-related protein Costal2

2002 • 60 citations

The Carboxyl-Terminal Domain of the Protein Kinase Fused Can Function as a Dominant Inhibitor of Hedgehog Signaling

2002 • 44 citations

The Fused Protein Kinase Regulates Hedgehog-stimulated Transcriptional Activation in Drosophila Schneider 2 Cells

2001 • 34 citations

Distinct Consequences of Sterol Sensor Mutations in Drosophila and Mouse patched Homologs

2002 • 33 citations