Cholesterol modification is necessary for controlled planar long-range activity of Hedgehog inDrosophilaepithelia

Targeted gene expression as a means of altering cell fates and generating dominant phenotypes

1993 • 9,476 citations

Hedgehog signaling in animal development: paradigms and principles

2001 • 2,919 citations

Dual Roles for Patched in Sequestering and Transducing Hedgehog

1996 • 889 citations

Compartment boundaries and the control of Drosopfiffa limb pattern by hedgehog protein

1994 • 842 citations

Identification of a Palmitic Acid-modified Form of Human Sonic hedgehog

1998 • 735 citations

Lipoprotein particles are required for Hedgehog and Wingless signalling

2005 • 678 citations

Functions of heparan sulfate proteoglycans in cell signaling during development

2004 • 659 citations

The Autosomal FLP-DFS Technique for Generating Germline Mosaics in Drosophila melanogaster

1996 • 652 citations

Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog

1992 • 585 citations

Dispatched, a Novel Sterol-Sensing Domain Protein Dedicated to the Release of Cholesterol-Modified Hedgehog from Signaling Cells

1999 • 571 citations

Cholesterol Modification of Sonic Hedgehog Is Required for Long-Range Signaling Activity and Effective Modulation of Signaling by Ptc1

2001 • 514 citations

FGF-induced vesicular release of Sonic hedgehog and retinoic acid in leftward nodal flow is critical for left–right determination

2005 • 514 citations

Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion

1998 • 505 citations

A freely diffusible form of Sonic hedgehog mediates long-range signalling

2001 • 485 citations

Dally cooperates with Drosophila Frizzled 2 to transduce Wingless signalling

1999 • 474 citations

Skinny Hedgehog, an Acyltransferase Required for Palmitoylation and Activity of the Hedgehog Signal

2001 • 462 citations

The Drosophila hedgehog gene is expressed specifically in posterior compartment cells and is a target of engrailed regulation.

1992 • 400 citations

The cell-surface proteoglycan Dally regulates Wingless signalling in Drosophila

1999 • 393 citations

Heparan sulfate proteoglycans are critical for the organization of the extracellular distribution of Wingless

2001 • 370 citations

Hedgehog Movement Is Regulated through tout velu–Dependent Synthesis of a Heparan Sulfate Proteoglycan

1999 • 367 citations

Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates

2004 • 360 citations

Hedgehog-Mediated Patterning of the Mammalian Embryo Requires Transporter-like Function of Dispatched

2002 • 327 citations

Novel Lipid Modifications of Secreted Protein Signals

2004 • 319 citations

A Hedgehog activity gradient contributes to AP axial patterning of the Drosophila wing

1997 • 300 citations

ThreeDrosophilaEXT genes shape morphogen gradients through synthesis of heparan sulfate proteoglycans

2003 • 274 citations

Drosophilaglypicans control the cell-to-cell movement of Hedgehog by a dynamin-independent process

2004 • 237 citations

Distinct and collaborative roles ofDrosophilaEXT family proteins in morphogen signalling and gradient formation

2004 • 228 citations

Abrogation of heparan sulfate synthesis inDrosophiladisrupts the Wingless, Hedgehog and Decapentaplegic signaling pathways

2004 • 221 citations

Drosophila hedgehog acts as a morphogen in cellular patterning

1994 • 215 citations

Regulated Endocytic Routing Modulates Wingless Signaling in Drosophila Embryos

2001 • 211 citations

Stability and association of Smoothened, Costal2 and Fused with Cubitus interruptus are regulated by Hedgehog

2003 • 200 citations

Biological activity of soluble wingless protein in cultured Drosophila imaginal disc cells

1994 • 194 citations

Sonic Hedgehog Induces the Segregation of Patched and Smoothened in Endosomes

2002 • 189 citations

Mouse Dispatched homolog1 Is Required for Long-Range, but Not Juxtacrine, Hh Signaling

2002 • 185 citations

The sterol-sensing domain of Patched protein seems to control Smoothened activity through Patched vesicular trafficking

2001 • 183 citations

Cholesterol Modification of Hedgehog Is Required for Trafficking and Movement, Revealing an Asymmetric Cellular Response to Hedgehog

2003 • 180 citations

Mouse dispatched mutants fail to distribute hedgehog proteins and are defective in hedgehog signaling

2002 • 179 citations

The Drosophila gene Serrate encodes an EGF-like transmembrane protein with a complex expression pattern in embryos and wing discs

1991 • 179 citations

Patched controls the Hedgehog gradient by endocytosis in a dynamin-dependent manner, but this internalization does not play a major role in signal transduction

2004 • 165 citations

Quantitative effects of hedgehog and decapentaplegic activity on the patterning of the Drosophila wing

1995 • 145 citations

Directionality of Wingless protein transport influences epidermal patterning in the Drosophila embryo

1999 • 133 citations

The cholesterol membrane anchor of the Hedgehog protein confers stable membrane association to lipid-modified proteins

2004 • 125 citations

The Drosophila Ortholog of the Human Wnt Inhibitor Factor Shifted Controls the Diffusion of Lipid-Modified Hedgehog

2005 • 124 citations

Regulation of Hedgehog signaling: a complex story

2004 • 112 citations

Distinct roles of Central missing and Dispatched in sending the Hedgehog signal

2001 • 112 citations

Peripodial Cells Regulate Proliferation and Patterning of Drosophila Imaginal Discs

2000 • 108 citations

Mouse Disp1 is required in sonic hedgehog-expressing cells for paracrine activity of the cholesterol-modified ligand

2004 • 108 citations

Phosphorylation of the fused protein kinase in response to signaling from hedgehog.

1996 • 105 citations

Wingless and Hedgehog pattern Drosophila denticle belts by regulating the production of short-range signals

1999 • 100 citations

Inactivation of dispatched 1 by the chameleon mutation disrupts Hedgehog signalling in the zebrafish embryo

2004 • 98 citations

Functional antagonists of sonic hedgehog reveal the importance of the N terminus for activity

1999 • 98 citations

Synergistic and antagonistic roles of the Sonic hedgehog N- and C-terminal lipids

2004 • 76 citations

Differential range and activity of various forms of the Hedgehog protein

2005 • 64 citations

Temporal modulation of the Hedgehog morphogen gradient by a patched-dependent targeting to lysosomal compartment

2004 • 61 citations

Hedgehog is required for activation of engrailed during regeneration of fragmented Drosophila imaginal discs

1999 • 56 citations

Intercellular signalling in Drosophila segment formation reconstructed in vitro

1993 • 50 citations

The roles of hedgehog, wingless and lines in patterning the dorsal epidermis in Drosophila

1996 • 48 citations

Heparan Sulfate Proteoglycans are critical for the organization of the extracellular distribution of Wingless

2001 • 31 citations