Expression of tissue‐specific autoantigens in the hematopoietic cells leads to activation‐induced cell death of autoreactive T cells in the secondary lymphoid organs

Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein

2002 • 2,371 citations

Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self

2001 • 1,043 citations

Aire regulates negative selection of organ-specific T cells

2003 • 789 citations

Class I–restricted Cross-Presentation of Exogenous Self-Antigens Leads to Deletion of Autoreactive CD8+ T Cells

1997 • 719 citations

Evidence that specific T lymphocytes may participate in the elimination of chronic myelogenous leukemia

2000 • 679 citations

Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells

2000 • 399 citations

CD4+ T Cell Tolerance to Parenchymal Self-Antigens Requires Presentation by Bone Marrow–derived Antigen-presenting Cells

1998 • 300 citations

Identity of cells that imprint H–2-restricted T-cell specificity in the thymus

1986 • 267 citations

T-cell tolerance toward a transgenic beta-cell antigen and transcription of endogenous pancreatic genes in thymus.

1994 • 223 citations

Promiscuous gene expression and central T-cell tolerance: more than meets the eye

2002 • 198 citations

Peripheral-antigen-expressing cells in thymic medulla: factors in self-tolerance and autoimmunity

1998 • 188 citations

Pancreatic gene expression in rare cells of thymic medulla: evidence for functional contribution to T cell tolerance

1997 • 183 citations

Self-antigen–presenting cells expressing diabetes-associated autoantigens exist in both thymus and peripheral lymphoid organs

2001 • 171 citations

Peripheral Deletion of Autoreactive CD8 T Cells by Cross Presentation of Self-Antigen Occurs by a Bcl-2–inhibitable Pathway Mediated by Bim

2002 • 160 citations

Intrathymic Expression of Genes Involved in Organ Specific Autoimmune Disease

1998 • 155 citations

Mechanisms of mouse spleen dendritic cell function in the generation of influenza-specific, cytolytic T lymphocytes.

1992 • 128 citations

Promiscuous expression of tissue antigens in the thymus: a key to T-cell tolerance and autoimmunity?

2000 • 117 citations

Strong T cell tolerance in parent----F1 bone marrow chimeras prepared with supralethal irradiation. Evidence for clonal deletion and anergy.

1990 • 112 citations

Absence of growth by most receptor-expressing fetal thymocytes in the presence of interleukin-2

1985 • 108 citations

Sampling of complementing self-antigen pools by thymic stromal cells maximizes the scope of central T cell tolerance

2001 • 98 citations

CD4 T Cell Tolerance to Nuclear Proteins Induced by Medullary Thymic Epithelium

1996 • 83 citations

Pancreatic Hormone Expression in the Murine Thymus: Localization in Dendritic Cells and Macrophages

1998 • 78 citations

Tolerogenicity of thymic epithelium

1990 • 74 citations

T-cell responsiveness to an oncogenic peripheral protein and spontaneous autoimmunity in transgenic mice.

1992 • 65 citations

Clonal Deletion of Simian Virus 40 Large T Antigen-Specific T Cells in the Transgenic Adenocarcinoma of Mouse Prostate Mice: An Important Role for Clonal Deletion in Shaping the Repertoire of T Cells Specific for Antigens Overexpressed in Solid Tumors

2002 • 43 citations

Pancreatic Hormone Expression in the Murine Thymus: Localization in Dendritic Cells and Macrophages

1998 • 29 citations

In Vivo Priming and Activation of Memory Cytotoxic T-Lymphocytes (CTL) by a Chimeric Simian Virus 40 T Antigen Expressing an Eight Amino Acid Residue Herpes Simplex Virus gB CTL Epitope

1993 • 14 citations

Peripheral antigen-expressing cells and autoimmunity

2002 • 12 citations