Notch signalling during peripheral T-cell activation and differentiation

NF-κB regulation in the immune system

2002 • 3,804 citations

Missing Pieces in the NF-κB Puzzle

2002 • 3,560 citations

A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment

2000 • 3,456 citations

Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia

2004 • 2,631 citations

Notch signalling: a simple pathway becomes complex

2006 • 2,481 citations

The Transcription Factor GATA-3 Is Necessary and Sufficient for Th2 Cytokine Gene Expression in CD4 T Cells

1997 • 2,317 citations

The lineage decisions of helper T cells

2002 • 1,678 citations

Deficient T Cell Fate Specification in Mice with an Induced Inactivation of Notch1

1999 • 1,392 citations

Signalling downstream of activated mammalian Notch

1995 • 1,375 citations

A Novel Proteolytic Cleavage Involved in Notch Signaling

2000 • 1,080 citations

Notch1 Expression in Early Lymphopoiesis Influences B versus T Lineage Determination

1999 • 956 citations

Instruction of Distinct CD4 T Helper Cell Fates by Different Notch Ligands on Antigen-Presenting Cells

2004 • 890 citations

Fringe is a glycosyltransferase that modifies Notch

2000 • 846 citations

A Ligand-Induced Extracellular Cleavage Regulates γ-Secretase-like Proteolytic Activation of Notch1

2000 • 841 citations

The Notch1 receptor is cleaved constitutively by a furin-like convertase

1998 • 720 citations

Modulation of Chromatin Structure Regulates Cytokine Gene Expression during T Cell Differentiation

1998 • 697 citations

Human CD4+CD25+ cells: a naturally occurring population of regulatory T cells

2001 • 615 citations

Fringe modulates Notch–ligand interactions

1997 • 578 citations

Inducible gene knockout of transcription factor recombination signal binding protein‐J reveals its essential role in T versus B lineage decision

2002 • 575 citations

γ-Secretase: proteasome of the membrane?

2004 • 543 citations

Ligand endocytosis drives receptor dissociation and activation in the Notch pathway

2000 • 492 citations

NF-κB Family of Transcription Factors: Central Regulators of Innate and Adaptive Immune Functions

2002 • 489 citations

An Activated Form of Notch Influences the Choice between CD4 and CD8 T Cell Lineages

1996 • 488 citations

Disruption of the mouse RBP-Jк gene results in early embryonic death

1995 • 478 citations

Structural Basis for Cooperativity in Recruitment of MAML Coactivators to Notch Transcription Complexes

2006 • 437 citations

Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia

2006 • 434 citations

Notch Activity Influences the αβ versus γδ T Cell Lineage Decision

1997 • 399 citations

Notch 1–Deficient Common Lymphoid Precursors Adopt a B Cell Fate in the Thymus

2001 • 392 citations

Fringe differentially modulates Jagged1 and Delta1 signalling through Notch1 and Notch2

2000 • 377 citations

Regulation of Notch Signaling by O-Linked Fucose

2002 • 369 citations

Constitutive activation of NF-kappaB and T-cell leukemia/lymphoma in Notch3 transgenic mice

2000 • 365 citations

The theory of the gene

1926 • 359 citations

Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex

2002 • 354 citations

F3/Contactin Acts as a Functional Ligand for Notch during Oligodendrocyte Maturation

2003 • 352 citations

The roles of receptor and ligand endocytosis in regulating Notch signaling

2005 • 335 citations

Sharp, an inducible cofactor that integrates nuclear receptor repression and activation

2001 • 330 citations

Phosphorylation by Glycogen Synthase Kinase-3β Down-regulates Notch Activity, a Link for Notch and Wnt Pathways

2003 • 324 citations

Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1

2000 • 323 citations

p300 Acts as a Transcriptional Coactivator for Mammalian Notch-1

2001 • 313 citations

An overview of the Notch signalling pathway

2003 • 309 citations

Regulation of αβ/γδ T Cell Lineage Commitment and Peripheral T Cell Responses by Notch/RBP-J Signaling

2004 • 306 citations

CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex

1999 • 301 citations

Inactivation of Notch1 in immature thymocytes does not perturb CD4 or CD8 T cell development

2001 • 300 citations

Notch1 augments NF-κB activity by facilitating its nuclear retention

2005 • 289 citations

Mastermind critically regulates Notch-mediated lymphoid cell fate decisions

2004 • 289 citations

Delta1-Notch3 Interactions Bias the Functional Differentiation of Activated CD4+ T Cells

2003 • 289 citations

Involvement of RBP-J in biological functions of mouse Notch1 and its derivatives

1997 • 289 citations

Notch signaling is an important regulator of type 2 immunity

2005 • 282 citations

Mutation in ankyrin repeats of the mouse Notch2 gene induces early embryonic lethality

1999 • 277 citations

Inhibitors of gamma-secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21.

2005 • 275 citations

NF-κB2 Is a Putative Target Gene of Activated Notch-1 via RBP-Jκ

1998 • 272 citations

p300 and PCAF Act Cooperatively To Mediate Transcriptional Activation from Chromatin Templates by Notch Intracellular Domains In Vitro

2002 • 267 citations

SHARP is a novel component of the Notch/RBP-Jkappa signalling pathway

2002 • 265 citations

Identification of a Family of Mastermind-Like Transcriptional Coactivators for Mammalian Notch Receptors

2002 • 260 citations

Glycogen Synthase Kinase-3β Modulates Notch Signaling and Stability

2002 • 255 citations

Deltex1 Redirects Lymphoid Progenitors to the B Cell Lineage by Antagonizing Notch1

2002 • 251 citations

Functional Interaction between the Mouse Notch1 Intracellular Region and Histone Acetyltransferases PCAF and GCN5

2000 • 239 citations

The Anti-apoptotic Effect of Notch-1 Requires p56 -dependent, Akt/PKB-mediated Signaling in T Cells

2004 • 238 citations

Comparative Analysis of the Human and Mouse Hey1 Promoter: Hey Genes Are New Notch Target Genes

2000 • 233 citations

Chaperone Activity of Protein O -Fucosyltransferase 1 Promotes Notch Receptor Folding

2005 • 232 citations

Differential responsiveness of the IL-5 and IL-4 genes to transcription factor GATA-3.

1998 • 228 citations

TCR-Mediated Notch Signaling Regulates Proliferation and IFN-γ Production in Peripheral T Cells

2003 • 228 citations

Stage-Specific and Differential Notch Dependency at the αβ and γδ T Lineage Bifurcation

2006 • 227 citations

kuzbanian-mediated cleavage of Drosophila Notch

2002 • 226 citations

Notch Subunit Heterodimerization and Prevention of Ligand-Independent Proteolytic Activation Depend, Respectively, on a Novel Domain and the LNR Repeats

2004 • 225 citations

Cutting Edge: Protective Effects of Notch-1 on TCR-Induced Apoptosis

1999 • 223 citations

DNER acts as a neuron-specific Notch ligand during Bergmann glial development

2005 • 222 citations

Notch Signaling Augments T Cell Responsiveness by Enhancing CD25 Expression

2003 • 218 citations

Notch-1 Regulates NF-κB Activity in Hemopoietic Progenitor Cells

2001 • 216 citations

Serrate1-induced Notch signalling regulates the decision between immunity and tolerance made by peripheral CD4+ T cells

2000 • 207 citations

Fringe Glycosyltransferases Differentially Modulate Notch1 Proteolysis Induced by Delta1 and Jagged1

2004 • 206 citations

GATA-3-dependent enhancer activity in IL-4 gene regulation.

1998 • 205 citations

A Role for Pref-1 and HES-1 in Thymocyte Development

2000 • 196 citations

The Nephroblastoma Overexpressed Gene (NOV/ccn3) Protein Associates with Notch1 Extracellular Domain and Inhibits Myoblast Differentiation via Notch Signaling Pathway

2002 • 195 citations

The Theory of the Gene

1917 • 194 citations

DrosophilaDeltex mediates Suppressor of Hairless-independent and late-endosomal activation of Notch signaling

2004 • 193 citations

Notch signaling promotes astrogliogenesis via direct CSL‐mediated glial gene activation

2002 • 193 citations

Requirement for Notch1 signals at sequential early stages of intrathymic T cell development

2005 • 187 citations

Rel/NF-κB can trigger the Notch signaling pathway by inducing the expression of Jagged1, a ligand for Notch receptors

1999 • 185 citations

Separation of Notch1 Promoted Lineage Commitment and Expansion/Transformation in Developing T Cells

2001 • 182 citations

Notch1 Regulates Maturation of CD4+ and CD8+ Thymocytes by Modulating TCR Signal Strength

2001 • 182 citations

RBP-Jκ/SHARP Recruits CtIP/CtBP Corepressors To Silence Notch Target Genes

2005 • 171 citations

Preferential role for NF-kappa B/Rel signaling in the type 1 but not type 2 T cell-dependent immune response in vivo.

1999 • 167 citations

Role of Rel-related factors in control of c-myc gene transcription in receptor-mediated apoptosis of the murine B cell WEHI 231 line.

1995 • 162 citations

Cutting Edge: Differential Responsiveness of the IL-5 and IL-4 Genes to Transcription Factor GATA-3

1998 • 162 citations

Notch Activation Is an Early and Critical Event during T-Cell Leukemogenesis in Ikaros-Deficient Mice

2005 • 158 citations

Cutting Edge: GATA-3-Dependent Enhancer Activity in IL-4 Gene Regulation

1998 • 158 citations

Overexpression of the Notch ligand, Jagged-1, induces alloantigen-specific human regulatory T cells

2003 • 157 citations

A protein binding to the Jk recombination sequence of immunoglobulin genes contains a sequence related to the integrase motif

1989 • 157 citations

T Cell Receptor Signaling: Beyond Complex Complexes

2004 • 151 citations

The Notch coactivator, MAML1, functions as a novel coactivator for MEF2C-mediated transcription and is required for normal myogenesis

2006 • 147 citations

Preferential Role for NF-κB/Rel Signaling in the Type 1 But Not Type 2 T Cell-Dependent Immune Response In Vivo

1999 • 146 citations

Characterization of a High-Molecular-Weight Notch Complex in the Nucleus of Notch^ic-Transformed RKE Cells and in a Human T-Cell Leukemia Cell Line

2002 • 142 citations

T cell leukemia-associated human Notch/translocation-associated Notch homologue has I kappa B-like activity and physically interacts with nuclear factor-kappa B proteins in T cells.

1996 • 136 citations

A secreted Delta1‐Fc fusion protein functions both as an activator and inhibitor of Notch1 signaling

2002 • 135 citations

Inhibitors of γ-secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21

2005 • 134 citations

The Nrarp Gene Encodes an Ankyrin-Repeat Protein That Is Transcriptionally Regulated by the Notch Signaling Pathway

2001 • 134 citations

NB-3/Notch1 Pathway via Deltex1 Promotes Neural Progenitor Cell Differentiation into Oligodendrocytes

2004 • 133 citations

Notch3 and pre-TCR interaction unveils distinct NF-κB pathways in T-cell development and leukemia

2006 • 131 citations

Microfibrillar Proteins MAGP-1 and MAGP-2 Induce Notch1 Extracellular Domain Dissociation and Receptor Activation

2006 • 129 citations

Notch1 mutations are important for leukemic transformation in murine models of precursor-T leukemia/lymphoma

2005 • 127 citations

Human Notch-1 Inhibits NF-κB Activity in the Nucleus Through a Direct Interaction Involving a Novel Domain

2001 • 125 citations

Expression of Activated Notch3 in Transgenic Mice Enhances Generation of T Regulatory Cells and Protects against Experimental Autoimmune Diabetes

2003 • 124 citations

The Interleukin-4 Enhancer CNS-2 Is Regulated by Notch Signals and Controls Initial Expression in NKT Cells and Memory-Type CD4 T Cells

2006 • 121 citations

Nuclear Localization of CBF1 Is Regulated by Interactions with the SMRT Corepressor Complex

2001 • 118 citations

Overexpression of the Notch target genes Hes in vivo induces lymphoid and myeloid alterations

2002 • 117 citations

Notch-Regulated Ankyrin-Repeat Protein Inhibits Notch1 Signaling: Multiple Notch1 Signaling Pathways Involved In T Cell Development

2003 • 116 citations

Induction of Antigen-Specific Regulatory T Cells following Overexpression of a Notch Ligand by Human B Lymphocytes

2003 • 115 citations

A Role for SKIP in EBNA2 Activation of CBF1-Repressed Promoters

2000 • 111 citations

Differential synergy of Notch and T cell receptor signaling determines αβ versus γδ lineage fate

2006 • 109 citations

A Reassessment of the Effect of Activated Notch1 on CD4 and CD8 T Cell Development

2002 • 102 citations

Notch ligands Delta-like1, Delta-like4 and Jagged1 differentially regulate activation of peripheral T helper cells

2005 • 101 citations

Deciphering the pathway from the TCR to NF-κB

2006 • 94 citations

CD40 Induces Interleukin-6 Gene Transcription in Dendritic Cells

2002 • 89 citations

Functional redundancy of the Notch gene family during mouse embryogenesis: Analysis of Notch gene expression in Notch3-deficient mice

2005 • 87 citations

Characterization of the Human and Mouse HEY1, HEY2, and HEYL Genes: Cloning, Mapping, and Mutation Screening of a New bHLH Gene Family

2000 • 87 citations

Basal Expression of IκBα Is Controlled by the Mammalian Transcriptional Repressor RBP-J (CBF1) and Its Activator Notch1

2003 • 86 citations

Expression of Notch ligands, Jagged1, 2 and Delta1 in antigen presenting cells in mice

2002 • 86 citations

Opposing Roles for RelB and Bcl-3 in Regulation of T-Box Expressed in T Cells, GATA-3, and Th Effector Differentiation

2005 • 84 citations

The Notch Pathway Intermediate HES-1 Silences CD4 Gene Expression

1998 • 83 citations

Sustained Notch1 signaling instructs the earliest human intrathymic precursors to adopt a γδ T-cell fate in fetal thymus organ culture

2003 • 78 citations

Cellular Notch responsiveness is defined by phosphoinositide 3-kinase-dependent signals

2006 • 77 citations

Notch ligation by Delta1 inhibits peripheral immune responses to transplantation antigens by a CD8+ cell–dependent mechanism

2003 • 73 citations

PKCθ mediates pre-TCR signaling and contributes to Notch3-induced T-cell leukemia

2004 • 71 citations

Notch ligation by Delta1 inhibits peripheral immune responses to transplantation antigens by a CD8+ cell–dependent mechanism

2003 • 68 citations

Cell cycle controlling the silencing and functioning of mammalian activators

2001 • 67 citations

Disruption of the mouse RBP-Jκ gene results in early embryonic death

1996 • 59 citations

The Notch Regulator Numb Links the Notch and TCR Signaling Pathways

2005 • 53 citations

Consequences of Notch-mediated induction of Jagged1

2004 • 48 citations

Notch1 co‐localizes with CD4 on activated T cells and Notch signaling is required for IL‐10 production

2005 • 46 citations

Notch1 expression on T cells is not required for CD4⁺ T helper differentiation

2004 • 45 citations

T Cells Develop Normally in the Absence of both Deltex1 and Deltex2

2006 • 45 citations

Functional interactions between an atypical NF-kappaB site from the rat CYP2B1 promoter and the transcriptional repressor RBP-Jkappa/CBF1

2000 • 33 citations

Linked Suppression in Peripheral T Cell Tolerance to the House Dust Mite Derived Allergen Der p 1

1999 • 30 citations

Characterization of the transcriptional expression of Notch-1 signaling pathway members, Deltex and HES-1, in developing mouse thymocytes

2002 • 29 citations

Binding of C/EBP and RBP (CBF1) to Overlapping Sites Regulates Interleukin-6 Gene Expression

2002 • 28 citations

Normal Immune System Development in Mice Lacking the Deltex-1 RING Finger Domain

2005 • 25 citations

Overexpression of HES-1 is not sufficient to impose T-cell differentiation on human hematopoietic stem cells

2005 • 18 citations

A Novel NF-κB-Regulated Site within the Human Iγ1 Promoter Requires p300 for Optimal Transcriptional Activity

2005 • 10 citations