Notch signaling promotes astrogliogenesis via direct CSL‐mediated glial gene activation

Notch Signaling: Cell Fate Control and Signal Integration in Development

1999 • 5,826 citations

A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain

1999 • 2,051 citations

Neurons derived from radial glial cells establish radial units in neocortex

2001 • 1,932 citations

Notch Signaling

1995 • 1,282 citations

Single factors direct the differentiation of stem cells from the fetal and adult central nervous system.

1996 • 1,164 citations

A Novel Proteolytic Cleavage Involved in Notch Signaling

2000 • 1,080 citations

Regulation of Gliogenesis in the Central Nervous System by the JAK-STAT Signaling Pathway

1997 • 993 citations

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and βAPP processing

2000 • 906 citations

Synergistic Signaling in Fetal Brain by STAT3-Smad1 Complex Bridged by p300

1999 • 841 citations

Timing of CNS Cell Generation

2000 • 825 citations

Hes1 and Hes5 as Notch effectors in mammalian neuronal differentiation

1999 • 817 citations

Presenilin is required for activity and nuclear access of Notch in Drosophila

1999 • 801 citations

Neurogenin Promotes Neurogenesis and Inhibits Glial Differentiation by Independent Mechanisms

2001 • 785 citations

Development of neuronal precursor cells and functional postmitotic neurons from embryonic stem cells in vitro

1996 • 775 citations

neurogenin1 Is Essential for the Determination of Neuronal Precursors for Proximal Cranial Sensory Ganglia

1998 • 731 citations

The Notch1 receptor is cleaved constitutively by a furin-like convertase

1998 • 720 citations

Radial Glial Identity Is Promoted by Notch1 Signaling in the Murine Forebrain

2000 • 716 citations

Transient Notch Activation Initiates an Irreversible Switch from Neurogenesis to Gliogenesis by Neural Crest Stem Cells

2000 • 715 citations

Notch Receptor Activation Inhibits Oligodendrocyte Differentiation

1998 • 675 citations

Conservation of the Notch signalling pathway in mammalian neurogenesis

1997 • 617 citations

Intracellular Cleavage of Notch Leads to a Heterodimeric Receptor on the Plasma Membrane

1997 • 615 citations

Coordinate Regulation of Motor Neuron Subtype Identity and Pan-Neuronal Properties by the bHLH Repressor Olig2

2001 • 614 citations

DNA Methylation Is a Critical Cell-Intrinsic Determinant of Astrocyte Differentiation in the Fetal Brain

2001 • 595 citations

The bHLH Transcription Factor Olig2 Promotes Oligodendrocyte Differentiation in Collaboration with Nkx2.2

2001 • 586 citations

MAML1, a human homologue of Drosophila Mastermind, is a transcriptional co-activator for NOTCH receptors

2000 • 576 citations

Contact-Dependent Inhibition of Cortical Neurite Growth Mediated by Notch Signaling

1999 • 568 citations

rax, Hes1, and notch1 Promote the Formation of Müller Glia by Postnatal Retinal Progenitor Cells

2000 • 519 citations

Neural bHLH Genes Control the Neuronal versus Glial Fate Decision in Cortical Progenitors

2001 • 513 citations

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants

1999 • 494 citations

Disruption of the mouse RBP-Jк gene results in early embryonic death

1995 • 478 citations

Calcium Depletion Dissociates and Activates Heterodimeric Notch Receptors

2000 • 411 citations

Notch1 and Notch3 Instructively Restrict bFGF-Responsive Multipotent Neural Progenitor Cells to an Astroglial Fate

2001 • 387 citations

The Ins and Outs of Notch Signaling

1997 • 386 citations

Notch signaling inhibits muscle cell differentiation through a CBF1-independent pathway

1996 • 372 citations

Helix-loop-helix factors in growth and differentiation of the vertebrate nervous system

1997 • 364 citations

Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations

1999 • 358 citations

Neocortical Development

1992 • 353 citations

Developmental Requirement of gp130 Signaling in Neuronal Survival and Astrocyte Differentiation

1999 • 324 citations

p300 Acts as a Transcriptional Coactivator for Mammalian Notch-1

2001 • 313 citations

Nuclear Notch1 signaling and the regulation of dendritic development

2000 • 310 citations

Notch signaling imposes two distinct blocks in the differentiation of C2C12 myoblasts

1999 • 304 citations

Cell interactions and gene interactions in peripheral neurogenesis.

1993 • 271 citations

Notch Inhibition of E47 Supports the Existence of a Novel Signaling Pathway

1998 • 261 citations

SKIP, a CBF1-Associated Protein, Interacts with the Ankyrin Repeat Domain of NotchIC To Facilitate NotchIC Function

2000 • 244 citations

lag-1, a gene required for lin-12 and glp-1 signaling in Caenorhabditis elegans, is homologous to human CBF1 and Drosophila Su(H)

1996 • 232 citations

Neural precursor differentiation into astrocytes requires signaling through the leukemia inhibitory factor receptor

1998 • 205 citations

Role of Deltex-1 as a Transcriptional Regulator Downstream of the Notch Receptor

2001 • 193 citations

Novel Notch alleles reveal a Deltex-dependent pathway repressing neural fate

2001 • 180 citations

Spatiotemporal selectivity of response to Notch1 signals in mammalian forebrain precursors

2001 • 180 citations

Inhibition of the DNA-binding activity of Drosophila suppressor of hairless and of its human homolog, KBF2/RBP-J kappa, by direct protein-protein interaction with Drosophila hairless.

1994 • 160 citations

Ligand-Induced Signaling in the Absence of Furin Processing of Notch1

2001 • 127 citations

A subset of Notch functions during Drosophila eye development require Su(H) and the E(spl) gene complex

1998 • 123 citations

An activity of Notch regulates JNK signalling and affects dorsal closure in Drosophila

1999 • 120 citations

Analysis of neuronal and glial phenotypes in brains of mice deficient in leukemia inhibitory factor

1998 • 118 citations

The Notch pathway: democracy and aristocracy in the selection of cell fate

1996 • 110 citations

Analysis of neuronal and glial phenotypes in brains of mice deficient in leukemia inhibitory factor

1998 • 108 citations

The Basic Helix-Loop-Helix Genehesr2Promotes Gliogenesis in Mouse Retina

2001 • 101 citations

The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity

2001 • 93 citations

The Abruptex Mutations of Notch Disrupt the Establishment of Proneural Clusters in Drosophila

1999 • 75 citations

Deleted Work

1955 • 0 citations