Expression of Activated Notch3 in Transgenic Mice Enhances Generation of T Regulatory Cells and Protects against Experimental Autoimmune Diabetes

Notch Signaling: Cell Fate Control and Signal Integration in Development

1999 • 5,826 citations

A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

1997 • 3,625 citations

Regulatory T Cells

2000 • 1,827 citations

Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

2001 • 1,659 citations

Induction of Tumor Immunity by Removing CD25+CD4+ T Cells: A Common Basis Between Tumor Immunity and Autoimmunity

1999 • 1,475 citations

Thymus and Autoimmunity: Production of CD25+CD4+ Naturally Anergic and Suppressive T Cells as a Key Function of the Thymus in Maintaining Immunologic Self-Tolerance

1999 • 1,223 citations

Regulatory T cells in the control of immune pathology

2001 • 1,197 citations

Streptozotocin-Induced Pancreatic Insulitis: New Model of Diabetes Mellitus

1976 • 972 citations

CTLA-4-Mediated Inhibition in Regulation of T Cell Responses: Mechanisms and Manipulation in Tumor Immunotherapy

2001 • 964 citations

Human CD4+CD25+ cells: a naturally occurring population of regulatory T cells

2001 • 615 citations

Certified Professionals

2001 • 533 citations

Evidence that the T cell repertoire of normal rats contains cells with the potential to cause diabetes. Characterization of the CD4+ T cell subset that inhibits this autoimmune potential.

1993 • 442 citations

An update on cytokines in the pathogenesis of insulin-dependent diabetes mellitus

1998 • 437 citations

Mice lacking the poly(ADP-ribose) polymerase gene are resistant to pancreatic beta-cell destruction and diabetes development induced by streptozocin

1999 • 368 citations

Constitutive activation of NF-kappaB and T-cell leukemia/lymphoma in Notch3 transgenic mice

2000 • 365 citations

CD25 Is a Marker for CD4+ Thymocytes That Prevent Autoimmune Diabetes in Rats, But Peripheral T Cells with This Function Are Found in Both CD25+ and CD25− Subpopulations

2000 • 334 citations

A defect in central tolerance in NOD mice

2001 • 272 citations

CD4+ regulatory T cells in autoimmunity and allergy

2002 • 236 citations

The third function of the thymus

2000 • 213 citations

Serrate1-induced Notch signalling regulates the decision between immunity and tolerance made by peripheral CD4+ T cells

2000 • 207 citations

TGF-β: the missing link in CD4+CD25+ regulatory T cell-mediated immunosuppression

2003 • 207 citations

Factors involved in the differentiation of TGF-beta-producing cells from naive CD4+ T cells: IL-4 and IFN-gamma have opposing effects, while TGF-beta positively regulates its own production.

1998 • 205 citations

Expression pattern of Notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal thymus components: distinct ligand–receptor interactions in intrathymic T cell development

1999 • 197 citations

Peripheral-antigen-expressing cells in thymic medulla: factors in self-tolerance and autoimmunity

1998 • 188 citations

Self-antigen–presenting cells expressing diabetes-associated autoantigens exist in both thymus and peripheral lymphoid organs

2001 • 171 citations

Cellular and Molecular Pathogenic Mechanisms of Insulin‐Dependent Diabetes Mellitus

2001 • 151 citations

Factors Involved in the Differentiation of TGF-β-Producing Cells from Naive CD4+ T Cells: IL-4 and IFN-γ Have Opposing Effects, While TGF-β Positively Regulates Its Own Production

1998 • 145 citations

The Thymus Contains a High Frequency of Cells that Prevent Autoimmune Diabetes on Transfer into Prediabetic Recipients

1996 • 128 citations

Notch1 and T-cell development: insights from conditional knockout mice

2001 • 79 citations

Insulin-dependent diabetes mellitus and its animal models

1999 • 78 citations

Type 1 diabetes

2001 • 67 citations

Notch signalling in the regulation of peripheral immunity

2001 • 57 citations

Tolerogenic strategies to halt or prevent type 1 diabetes

2001 • 48 citations

MHC Class I-Restricted Determinants on the Glutamic Acid Decarboxylase 65 Molecule Induce Spontaneous CTL Activity

2001 • 44 citations

Age-Dependent Sensitivity to Streptozotocin of Pancreatic Islets Isolated from Female NOD Mice

1995 • 8 citations