Vitamin E suppresses diacylglycerol (DAG) level in thrombin-stimulated endothelial cells through an increase of DAG kinase activity

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 47,127 citations

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Studies and Perspectives of Protein Kinase C

1986 • 5,148 citations

Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides

1983 • 1,937 citations

Signaling through phosphatidylcholine breakdown.

1990 • 1,362 citations

Quantitative measurement of sn-1,2-diacylglycerols present in platelets, hepatocytes, and ras- and sis-transformed normal rat kidney cells.

1986 • 999 citations

The regulation and cellular functions of phosphatidylcholine hydrolysis

1990 • 862 citations

Beta-adrenergic receptors: biochemical mechanisms of physiological regulation

1984 • 672 citations

Lipid activation of protein kinase C.

1991 • 566 citations

Role of phospholipases in generating lipid second messengers in signal transduction ¹

1991 • 545 citations

Inhibition of cell proliferation by alpha-tocopherol. Role of protein kinase C.

1991 • 510 citations

Phosphatidate accumulation in hormone-treated hepatocytes via a phospholipase D mechanism.

1987 • 472 citations

Phosphatidylcholine Hydrolysis by Phospholipase D Determines Phosphatidate and Diglyceride Levels in Chemotactic Peptide-stimulated Human Neutrophils

1989 • 429 citations

Biology of Endothelial Cells

1984 • 426 citations

Phosphoinositides and receptor mechanisms

1987 • 320 citations

Signal transduction via phosphatidylcholine cycles

1989 • 314 citations

Correlation between thrombin-induced prostacyclin production and inositol trisphosphate and cytosolic free calcium levels in cultured human endothelial cells.

1987 • 281 citations

Increased endothelial albumin permeability mediated by protein kinase C activation.

1990 • 271 citations

The mitogenic effect of 15- and 12-hydroxyeicosatetraenoic acid on endothelial cells may be mediated via diacylglycerol kinase inhibition.

1987 • 181 citations

P2-Purinergic Agonists Stimulate Phosphodiesteratic Cleavage of Phosphatidylcholine in Endothelial Cells

1989 • 180 citations

Formation of diacylglycerol by a phospholipase D-phosphatidate phosphatase pathway specific for phosphatidylcholine in endothelial cells

1988 • 149 citations

Vitamin E inhibits platelet phospholipase A2

1986 • 149 citations

sn-1,2-Diacylglycerol kinase of Escherichia coli. Mixed micellar analysis of the phospholipid cofactor requirement and divalent cation dependence.

1986 • 148 citations

The Regulation of Platelet-activating Factor Production in Endothelial Cells

1989 • 141 citations

A membrane-bound diacylglycerol kinase that selectively phosphorylates arachidonoyl-diacylglycerol. Distinction from cytosolic diacylglycerol kinase and comparison with the membrane-bound enzyme from Escherichia coli.

1988 • 134 citations

Thrombin and histamine activate phospholipase C in human endothelial cells via a phorbol ester‐sensitive pathway

1988 • 117 citations

Modulation of rat brain cytosolic phosphatidate phosphohydrolase: Effect of cationic amphiphilic drugs and divalent cations

1987 • 103 citations

Propranolol-induced inhibition of rat brain cytoplasmic phosphatidate phosphohydrolase

1983 • 92 citations

Regulation of diacylglycerol kinase reaction in Swiss 3T3 cells. Increased phosphorylation of endogenous diacylglycerol and decreased phosphorylation of didecanoylglycerol in response to platelet-derived growth factor.

1988 • 89 citations

Protein kinase C activation alters the sensitivity of agonist-stimulated endothelial-cell prostacyclin production to intracellular Ca2+

1989 • 83 citations

Decreased prostacyclin synthesis in vitamin E-deficient rabbit aorta

1981 • 78 citations

Thrombin stimulation of human endothelial cell phospholipase D activity. Regulation by phospholipase C, protein kinase C, and cyclic adenosine 3'5'-monophosphate.

1992 • 71 citations

Use of diacylglycerol kinase to quantitate picomole levels of 1,2-diacylglycerol

1979 • 67 citations

Phosphatidylcholine metabolism in endothelial cells: Evidence for phospholipase A and a novel Ca2+-independent phospholipase C

1987 • 58 citations

Stimulation of phosphatidylcholine breakdown and diacylglycerol production by growth factors in Swiss-3T3 cells

1989 • 56 citations

Pathways of arachidonic acid liberation in thrombin and calcium ionophore A23187-stimulated human endothelial cells: Respective roles of phospholipids and triacylglycerol and evidence for diacylglycerol generation from phosphatidylcholine

1987 • 56 citations

R,R,R-α-tocopherol potentiates prostacyclin release in human endothelial cells. Evidence for structural specificity of the tocopherol molecule

1990 • 53 citations

Phosphorylation of diacylglycerol kinase in vitro by protein kinase C

1989 • 53 citations

Bradykinin stimulates phosphodiesteratic cleavage of phosphatidylcholine in cultured endothelial cells

1988 • 52 citations

The uptake of (R,R,R)α‐tocopherol by human endothelial cells in culture

1990 • 48 citations

Modulation of platelet thromboxane and malonaldehyde by dietary vitamin E and linoleate

1983 • 48 citations

Role of Protein Kinase C in the Regulation of Prostaglandin Synthesis in Human Endothelium

1992 • 43 citations

Protein kinase C and cyclic AMP modulate thrombin-induced platelet-activating factor synthesis in human endothelial cells

1991 • 43 citations

Regulation by vitamin E of phosphatidylcholine metabolism in rat heart

1987 • 39 citations

The roles of protein kinase C and intracellular Ca2+ in the secretion of von Willebrand factor from human vascular endothelial cells

1992 • 31 citations

Enhancement of thrombin‐ and lonomycin‐stimulated prostacyclin and platelet‐activating factor production in cultured endothelial cells by a tumor‐promoting phorbol ester

1990 • 30 citations

Differential metabolism of diradyl glycerol molecular subclasses and molecular species by rabbit brain diglyceride kinase.

1990 • 29 citations

Effect of vitamin E enrichment on arachidonic acid release and cellular phospholipids in cultured human endothelial cells

1988 • 24 citations

Effects of free fatty acids and acyl‐coenzyme a on diacylglycerol kinase in rat brain

1989 • 10 citations