Epidermal Growth Factor Receptor Stimulation of Diacylglycerol Kinase

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 47,127 citations

Tyrosine Kinase Inhibition: An Approach to Drug Development

1995 • 1,655 citations

Frequent expression of a mutant epidermal growth factor receptor in multiple human tumors.

1995 • 633 citations

Amplified and rearranged epidermal growth factor receptor genes in human glioblastomas reveal deletions of sequences encoding portions of the N- and/or C-terminal tails.

1992 • 609 citations

Secretory phospholipase A2 generates the novel lipid mediator lysophosphatidic acid in membrane microvesicles shed from activated cells

1995 • 523 citations

Type I phosphatidylinositol 4-phosphate 5-kinase isoforms are specifically stimulated by phosphatidic acid

1994 • 410 citations

Raf-1 Kinase Possesses Distinct Binding Domains for Phosphatidylserine and Phosphatidic Acid

1996 • 402 citations

Phosphatidic acid is a specific activator of phosphatidylinositol-4-phosphate kinase.

1992 • 368 citations

Cellular ras activity and phospholipid metabolism

1988 • 331 citations

Phosphatidic acid activation of protein kinase C-ζ overexpressed in COS cells: comparison with other protein kinase C isotypes and other acidic lipids

1994 • 308 citations

Mitogenic action of lysophosphatidic acid and phosphatidic acid on fibroblasts. Dependence on acyl-chain length and inhibition by suramin

1992 • 266 citations

Expression of mutated epidermal growth factor receptor by non-small cell lung carcinomas.

1993 • 246 citations

Amplification of the structurally and functionally altered epidermal growth factor receptor gene (c-erbB) in human brain tumors.

1988 • 218 citations

Phosphoinositide kinase, diacylglycerol kinase, and phospholipase C activities associated to the cytoskeleton: effect of epidermal growth factor.

1991 • 202 citations

Selective inhibition of the epidermal growth factor and HER2/neu receptors by tyrphostins

1993 • 200 citations

Transformational and altered signal transduction by a naturally occurring mutant EGF receptor.

1996 • 195 citations

Phosphatidic and lysophosphatidic acid production in phospholipase C-and thrombin-treated platelets. possible involvement of a platelet lipase

1978 • 166 citations

A Deletion Mutation within the Ligand Binding Domain Is Responsible for Activation of Epidermal Growth Factor Receptor Gene in Human Brain Tumors

1990 • 158 citations

Phosphatidylethanol Biosynthesis in Ethanol-exposed NG108-15 Neuroblastoma X Glioma Hybrid Cells

1989 • 151 citations

Stimulation by phospholipids of a protein-tyrosine-phosphatase containing two src homology 2 domains.

1993 • 107 citations

Rapid analysis of fatty acids in plasma lipids

1990 • 107 citations

Differential Modulation of Mitogen-activated Protein (MAP) Kinase/Extracellular Signal-related Kinase Kinase and MAP Kinase Activities by a Mutant Epidermal Growth Factor Receptor

1995 • 87 citations

The inhibition of the GTPase activating protein-Ha-ras interaction by acidic lipids is due to physical association of the C-terminal domain of the GTPase activating protein with micellar structures.

1991 • 86 citations

Properties of Microsomal and Soluble Diacylglycerol Kinase in Rat Liver

1978 • 81 citations

Arachidonoyl-diacylglycerol kinase from bovine testis. Purification and properties.

1994 • 79 citations

Decreased activities of phosphatidate phosphohydrolase and phospholipase D in ras and tyrosine kinase (fps) transformed fibroblasts.

1993 • 71 citations

Diacylglycerol kinase is phosphorylated in vivo upon stimulation of the epidermal growth factor receptor and serine/threonine kinases, including protein kinase C-ε

1993 • 70 citations

The GTPase stimulatory activities of the neurofibromatosis type 1 and the yeast IRA2 proteins are inhibited by arachidonic acid.

1991 • 69 citations

Inhibition by phospholipids of the interaction between R-ras, rho, and their GTPase-activating proteins.

1989 • 66 citations

Altered signal transduction in erbB-transformed cells. Implication of enhanced inositol phospholipid metabolism in erbB-induced transformation.

1987 • 62 citations

Evidence That the Bradykinin-induced Activation of Phospholipase D and of the Mitogen-activated Protein Kinase Cascade Involve Different Protein Kinase C Isoforms

1995 • 52 citations

Phosphatidic Acid Directly Activates Endothelial Cell Protein Kinase C

1993 • 47 citations

Epidermal-growth-factor-induced production of phosphatidylalcohols by HeLa cells and A431 cells through activation of phospholipase D

1992 • 39 citations

Interleukin-11 induces phosphatidic acid formation and activates map kinase in mouse 3T3-L1 cells

1995 • 35 citations

Phosphatidic acid promotes phosphoinositide metabolism and DNA synthesis in cultured cortical astrocytes

1994 • 35 citations

Epidermal growth factor stimulates distinct diradylglycerol species generation in Swiss 3T3 fibroblasts: evidence for a potential phosphatidylcholine-specific phospholipase C-catalysed pathway

1994 • 30 citations

Epidermal growth factor stimulates diacylglycerol kinase in isolated plasma membrane vesicles from A431 cells

1985 • 27 citations

The mitogenic activities of phosphatidate are acyl-chain-length dependent and calcium independent in C3H/10T1/2 cells.

1991 • 27 citations

Proposed role of phosphatidic acid in the extracellular control of the transition from G2 phase to mitosis exerted by epidermal growth factor in A431 cells.

1992 • 25 citations

Time-course changes in content and fatty acid composition of phosphatidic acid from rat thymocytes during concanavalin A stimulation

1995 • 19 citations

Reversible inhibition by ethanol of Mg2+-dependent phosphatidate phosphohydrolase: an in vitro study in the rat reticulocyte

1995 • 6 citations