Positive and Negative Regulation of V(D)J Recombination by the E2A Proteins

Somatic generation of antibody diversity

1983 • 3,275 citations

RAG-1-deficient mice have no mature B and T lymphocytes

1992 • 2,859 citations

A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins

1989 • 2,706 citations

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

1992 • 2,618 citations

RAG-1 and RAG-2, Adjacent Genes That Synergistically Activate V(D)J Recombination

1990 • 1,450 citations

The V(D)J recombination activating gene, RAG-1

1989 • 1,164 citations

Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages

1992 • 1,116 citations

A developmental pathway involving four phenotypically and functionally distinct subsets of CD3-CD4-CD8- triple-negative adult mouse thymocytes defined by CD44 and CD25 expression.

1993 • 833 citations

E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements

1994 • 766 citations

Ordered rearrangement of immunoglobulin heavy chain variable region segments.

1984 • 736 citations

Developmentally controlled and tissue-specific expression of unrearranged VH gene segments

1985 • 710 citations

Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps

1995 • 703 citations

The helix-loop-helix gene E2A is required for B cell formation

1994 • 679 citations

Modulation of Epithelial Cell Growth by Intraepithelial γδ T Cells

1994 • 644 citations

The Mechanism of V(D)J Joining: Lessons from Molecular, Immunological, and Comparative Analyses

1994 • 579 citations

Junctional sequences of T cell receptor γδ genes: Implications for γδ T cell lineages and for a novel intermediate of V-(D)-J joining

1989 • 572 citations

Developmentally ordered appearance of thymocytes expressing different T-cell antigen receptors

1988 • 540 citations

Limited diversity of γδ antigen receptor genes of thy-1+ dendritic epidermal cells

1988 • 522 citations

Structure and function of helix-loop-helix proteins

1994 • 496 citations

Two Distinct Transcription Factors that Bind the Immunoglobulin Enhancer μE5/κE2 Motif

1990 • 478 citations

The Structure, Function, and Molecular Genetics of the gamma/delta T Cell Receptor

1989 • 476 citations

V(D)J Recombination: Molecular Biology and Regulation

1992 • 464 citations

Introduced T cell receptor variable region gene segments recombine in pre-B cells: Evidence that B and T cells use a common recombinase

1986 • 452 citations

Development and Selection of T Cells: Facts and Puzzles

1995 • 450 citations

Activation of immunoglobulin kappa gene rearrangement correlates with induction of germline kappa gene transcription

1989 • 432 citations

Ku86-Deficient Mice Exhibit Severe Combined Immunodeficiency and Defective Processing of V(D)J Recombination Intermediates

1996 • 430 citations

Diversity of murine gamma genes and expression in fetal and adult T lymphocytes

1986 • 423 citations

Diversity, rearrangement, and expression of murine T cell gamma genes

1986 • 405 citations

Restoration of T Cell Development in RAG-2-Deficient Mice by Functional TCR Transgenes

1993 • 403 citations

E2A Deficiency Leads to Abnormalities in αβ T-Cell Development and to Rapid Development of T-Cell Lymphomas

1997 • 400 citations

Double-strand signal sequence breaks in V(D)J recombination are blunt, 5'-phosphorylated, RAG-dependent, and cell cycle regulated.

1993 • 381 citations

B-Lymphocyte Development Is Regulated by the Combined Dosage of Three Basic Helix-Loop-Helix Genes, E2A, E2-2, and HEB†

1996 • 339 citations

T-cell receptor δ gene rearrangements in early thymocytes

1987 • 324 citations

The adult T-cell receptor 5-chain is diverse and distinct from that of fetal thymocytes

1988 • 320 citations

Recombination between immunoglobulin variable region gene segments is enhanced by transcription

1986 • 308 citations

Cell Type–Specific Chromatin Structure Determines the Targeting of V(D)J Recombinase Activity In Vitro

1996 • 305 citations

ACCESSIBILITY CONTROL OF ANTIGEN-RECEPTOR VARIABLE-REGION GENE ASSEMBLY: Role ofcis-Acting Elements

1996 • 295 citations

EBF and E47 Collaborate to Induce Expression of the Endogenous Immunoglobulin Surrogate Light Chain Genes

1997 • 282 citations

Inhibition of T Cell and Promotion of Natural Killer Cell Development by the Dominant Negative Helix Loop Helix Factor Id3

1997 • 279 citations

Induction of Early B Cell Factor (EBF) and Multiple B Lineage Genes by the Basic Helix-Loop-Helix Transcription Factor E12

1998 • 268 citations

Constitutive expression of the Id1 gene impairs mouse B cell development

1994 • 266 citations

Helix-loop-helix transcription factor E47 activates germ-line immunoglobulin heavy-chain gene transcription and rearrangement in a pre-T-cell line.

1991 • 240 citations

Initiation of V(D)J recombination in vitro obeying the 12/23 rule

1996 • 232 citations

Separate elements control DJ and VDJ rearrangement in a transgenic recombination substrate.

1990 • 224 citations

Developmental Biology of T Cell Receptors

1989 • 223 citations

Distinct antigen receptor repertoires of two classes of murine epithelium-associated T cells

1989 • 215 citations

Both E12 and E47 Allow Commitment to the B Cell Lineage

1997 • 209 citations

Rearrangement and diversity of T cell receptor β chain genes in thymocytes: A critical role for the β chain in development

1993 • 198 citations

Developmentally regulated and strain-specific expression of murine VH gene families.

1988 • 186 citations

Different gamma delta T-cell receptors are expressed on thymocytes at different stages of development.

1989 • 183 citations

A T-cell-specific transcriptional enhancer element 3' of C alpha in the human T-cell receptor alpha locus.

1989 • 165 citations

Characterization of broken DNA molecules associated with V(D)J recombination.

1993 • 163 citations

A T Cell-Specific Transcriptional Enhancer within the Human T Cell Receptor δ Locus

1990 • 140 citations

α β and γ δ T cells can share a late common precursor

1995 • 139 citations

Helix-loo-helix proteins in the regulation of immunoglobulin gene transcription

1992 • 139 citations

TCR beta and TCR alpha gene enhancers confer tissue- and stage-specificity on V(D)J recombination events.

1993 • 132 citations

VH gene family utilization in colonies derived from B and pre-B cells detected by the RNA colony blot assay.

1986 • 127 citations

V_H‐gene expression in murine lipopolysaccharide blasts distributes over the nine known V_H‐gene groups and may be random

1985 • 122 citations

In-frame TCR δ gene rearrangements play a critical role in the αβ/γδ T cell lineage decision

1995 • 122 citations

Ordered rearrangement of variable region genes of the T cell receptor gamma locus correlates with transcription of the unrearranged genes.

1993 • 111 citations

Commitment to the T cell receptor‐αβ or ‐γδ lineages can occur just prior to the onset of CD4 and CD8 expression among immature thymocytes

1992 • 110 citations

E47 activates the Ig-heavy chain and TdT loci in non-B cells.

1996 • 108 citations

Developmentally regulated fetal thymic and extrathymic T-cell receptor gamma delta gene expression.

1990 • 99 citations

Temporal and lineage-specific control of T cell receptor alpha/delta gene rearrangement by T cell receptor alpha and delta enhancers.

1994 • 94 citations

Control of γδ T‐Cell Development

1991 • 93 citations

Gene rearrangement and B-cell development

1993 • 92 citations

Accessibility and the developmental regulation of V(D)J recombination

1997 • 85 citations

Differential activation of transcription versus recombination of transgenic T cell receptor beta variable region gene segments in B and T lineage cells.

1994 • 85 citations

Regulated expression and structure of T cell receptor gamma/delta transcripts in human thymic ontogeny.

1991 • 82 citations

Frequency of VH81x usage during B cell development: initial decline in usage is independent of Ig heavy chain cell surface expression.

1996 • 80 citations

Functional analysis of the murine T-cell receptor beta enhancer and characteristics of its DNA-binding proteins.

1990 • 75 citations

Enhancer Control of Local Accessibility to V(D)J Recombinase

1997 • 68 citations

Identification of an Essential Site for Transcriptional Activation within the Human T-Cell Receptor δ Enhancer

1991 • 58 citations

The temporal order of appearance of transcripts from unrearranged and rearranged Ig genes in murine fetal liver.

1990 • 58 citations

Developmentally controlled and tissue-specific expression of unrearranged VH gene segments. Cell. 1985. 40: 271-281.

2012 • 55 citations

Induced rearrangement of kappa genes in the BLIN-1 human pre-B cell line correlates with germline J-C kappa and V kappa transcription.

1991 • 51 citations

Regulation of Immunoglobulin Gene Transcription

1992 • 50 citations

Developmental Regulation of VDJ Recombination By the Core Fragment of the T Cell Receptor α Enhancer

1997 • 48 citations

Variable region (V delta) gene segment most frequently utilized in adult thymocytes is 3' of the constant (C delta) region.

1988 • 44 citations

V-D-J rearrangements at the T cell receptor σ locus in mouse thymocytes of the αβ lineage

1995 • 43 citations

In vitro V(D)J recombination: Signal joint formation

1996 • 38 citations

Functional Analysis of the Murine T-Cell Receptor β Enhancer and Characteristics of Its DNA-Binding Proteins

1990 • 28 citations

Functional analysis of the Vϒ3 promoter of the murine ϒδ T-cell receptor

1994 • 15 citations

Functional analysis of the V gamma 3 promoter of the murine gamma delta T-cell receptor.

1994 • 8 citations