Phosphodiesterase 4 inhibitors as novel anti-inflammatory agents

Oocyte Maturation Involves Compartmentalization and Opposing Changes of cAMP Levels in Follicular Somatic and Germ Cells: Studies Using Selective Phosphodiesterase Inhibitors

1996 • 350 citations

Isolation and Characterization of PDE8A, a Novel Human cAMP-Specific Phosphodiesterase

1998 • 224 citations

Isolation and characterization of a mammalian gene encoding a high-affinity cAMP phosphodiesterase.

1989 • 192 citations

Characterization of five different proteins produced by alternatively spliced mRNAs from the human cAMP-specific phosphodiesterase PDE4D gene

1997 • 186 citations

Proposal for Pharmacologically Distinct Conformers of PDE4 Cyclic AMP Phosphodiesterases

1997 • 185 citations

Anti-inflammatory activities of cAMP-elevating agents: enhancement of IL-10 synthesis and concurrent suppression of TNF production

1998 • 185 citations

Chronic Antidepressant Administration Increases the Expression of cAMP-Specific Phosphodiesterase 4A and 4B Isoforms

1999 • 175 citations

cAMP-specific phosphodiesterase HSPDE4D3 mutants which mimic activation and changes in rolipram inhibition triggered by protein kinase A phosphorylation of Ser-54: generation of a molecular model

1998 • 160 citations

1,4-Cyclohexanecarboxylates: Potent and Selective Inhibitors of Phosophodiesterase 4 for the Treatment of Asthma

1998 • 146 citations

In vitro differentiation of human monocytes to macrophages: change of PDE profile and its relationship to suppression of tumour necrosis factor‐α release by PDE inhibitors

1997 • 143 citations

A low-Km, rolipram-sensitive, cAMP-specific phosphodiesterase from human brain. Cloning and expression of cDNA, biochemical characterization of recombinant protein, and tissue distribution of mRNA.

1993 • 130 citations

The effect of a novel orally active selective PDE4 isoenzyme inhibitor (CDP840) on allergen-induced responses in asthmatic subjects

1997 • 121 citations

Characterization of the Rolipram-Sensitive, Cyclic AMP-Specific Phosphodiesterases: Identification and Differential Expression of Immunologically Distinct Forms in the Rat Brain

1998 • 115 citations

Challenge of human Jurkat T-cells with the adenylate cyclase activator forskolin elicits major changes in cAMP phosphodiesterase (PDE) expression by up-regulating PDE3 and inducing PDE4D1 and PDE4D2 splice variants as well as down-regulating a novel PDE4A splice variant

1997 • 115 citations

Characterization of the structure of a low Km, rolipram-sensitive cAMP phosphodiesterase. Mapping of the catalytic domain.

1992 • 113 citations

Evidence that cyclic AMP phosphodiesterase inhibitors suppress TNFα generation from human monocytes by interacting with a ‘low‐affinity’ phosphodiesterase 4 conformer

1996 • 113 citations

Enhancement of motility and acrosome reaction in human spermatozoa: differential activation by type-specific phosphodiesterase inhibitors

1998 • 108 citations

Effects of theophylline and rolipram on leukotriene C₄ (LTC₄) synthesis and chemotaxis of human eosinophils from normal and atopic subjects

1996 • 106 citations

Induction of Phosphodiesterases 3B, 4A4, 4D1, 4D2, and 4D3 in Jurkat T-cells and in Human Peripheral Blood T-lymphocytes by 8-Bromo-cAMP and Gs-coupled Receptor Agonists

1998 • 101 citations

Molecular cloning and transient expression in COS7 cells of a novel human PDE4B cAMP-specific phosphodiesterase, HSPDE4B3

1997 • 101 citations

Emesis induced by inhibitors of type IV cyclic nucleotide phosphodiesterase (PDE IV) in the ferret

1999 • 97 citations

The inhibition of antigen‐induced eosinophilia and bronchoconstriction by CDP840, a novel stereo‐selective inhibitor of phosphodiesterase type 4

1996 • 95 citations

Structure of two rat genes coding for closely related rolipram-sensitive cAMP phosphodiesterases. Multiple mRNA variants originate from alternative splicing and multiple start sites.

1994 • 92 citations

Modulation of cell adhesion molecule expression and function on human lung microvascular endothelial cells by inhibition of phosphodiesterases 3 and 4

1998 • 91 citations

Effects of phosphodiesterase inhibitors on human lung mast cell and basophil function

1997 • 88 citations

SB 207499 (Ariflo), a second generation phosphodiesterase 4 inhibitor, reduces tumor necrosis factor alpha and interleukin-4 production in vivo.

1998 • 87 citations

Subcellular Localization of Rolipram-sensitive, cAMP-specific Phosphodiesterases

1998 • 85 citations

Type 4 Cyclic Adenosine Monophosphate Phosphodiesterase as a Therapeutic Target in Chronic Lymphocytic Leukemia

1998 • 83 citations

The Toxicity of Repeated Exposures to Rolipram, a Type IV Phosphodiesterase Inhibitor, in Rats

1996 • 76 citations

Phosphodiesterase profile of human B lymphocytes from normal and atopic donors and the effects of PDE inhibition on B cell proliferation

1998 • 75 citations

The cDNA of a human lymphocyte cyclic-AMP phosphodiesterase (PDE IV) reveals a multigene family

1993 • 75 citations

The phosphodiesterase inhibitors pentoxifylline and rolipram prevent diabetes in NOD mice.

1998 • 72 citations

Phosphodiesterase profiles of highly purified human peripheral blood leukocyte populations from normal and atopic individuals: A comparative study☆☆☆★★★

1997 • 72 citations

Suppression of Acute Lung Injury in Mice by an Inhibitor of Phosphodiesterase Type 4

1998 • 71 citations

Antiasthmatic activity of the second-generation phosphodiesterase 4 (PDE4) inhibitor SB 207499 (Ariflo) in the guinea pig.

1998 • 69 citations

Type 4 Cyclic Adenosine Monophosphate Phosphodiesterase as a Therapeutic Target in Chronic Lymphocytic Leukemia

1998 • 68 citations

The effects of phosphodiesterase type 4 inhibitors on tumour necrosis factor‐α and leukotriene B₄ in a novel human whole blood assay

1999 • 68 citations

Human Recombinant Phosphodiesterase 4B2B Binds (R)-Rolipram at a Single Site with Two Affinities

1997 • 67 citations

Phosphodiesterase 4B Gene Transcription Is Activated by Lipopolysaccharide and Inhibited by Interleukin-10 in Human Monocytes

1999 • 67 citations

Stimulation of p70S6 kinase via a growth hormone-controlled phosphatidylinositol 3-kinase pathway leads to the activation of a PDE4A cyclic AMP-specific phosphodiesterase in 3T3-F442A preadipocytes

1998 • 67 citations

Effects of rolipram on cyclic AMP levels in alveolar macrophages and lipopolysaccharide‐induced inflammation in mouse lung

1998 • 66 citations

Differential regulation of human antigen-specific Th1 and Th2 lymphocyte responses by isozyme selective cyclic nucleotide phosphodiesterase inhibitors.

1997 • 63 citations

Amelioration of collagen II-induced arthritis in rats by the type IV phosphodiesterase inhibitor Rolipram

1997 • 61 citations

Cyclic AMP‐mediated regulation of vascular smooth muscle cell cyclic AMP phosphodiesterase activity

1997 • 59 citations

Phosphodiesterase inhibition improves agonist-induced relaxation of hypertensive pulmonary arteries.

1997 • 57 citations

Chronic obstructive pulmonary disease: new opportunities for drug development

1998 • 52 citations

The effect of the specific phosphodiesterase-IV-inhibitor rolipram on the ureteral peristalsis of the rabbit in vitro and in vivo.

1998 • 50 citations

Differential efficacy of lymphocyte- and monocyte-selective pretreatment with a type 4 phosphodiesterase inhibitor on antigen-driven proliferation and cytokine gene expression

1997 • 49 citations

Reduced DNA synthesis and cell viability in small cell lung carcinoma by treatment with cyclic AMP phosphodiesterase inhibitors

1998 • 48 citations

Protection against blood–brain barrier disruption in focal cerebral ischemia by the type IV phosphodiesterase inhibitor BBB022: a quantitative study

1998 • 48 citations

Isolation of a cDNA encoding a human rolipram-sensitive cyclic AMP phosphodiesterase (PDE IVD)

1994 • 46 citations

Delayed treatment with rolipram protects against neuronal damage following global ischemia in rats

1997 • 44 citations

Reduction of bone loss by denbufylline, an inhibitor of phosphodiesterase 4

1997 • 43 citations

Novel, Potent, and Selective Phosphodiesterase-4 Inhibitors as Antiasthmatic Agents: Synthesis and Biological Activities of a Series of 1-Pyridylnaphthalene Derivatives

1999 • 41 citations

THE EFFECT OF THE SPECIFIC PHOSPHODIESTERASE-IV-INHIBITOR ROLIPRAM ON THE URETHERAL PERISTALSIS OF THE RABBIT IN VITRO AND IN VIVO

1998 • 40 citations

Inhibition of eotaxin‐mediated human eosinophil activation and migration by the selective cyclic nucleotide phosphodiesterase type 4 inhibitor rolipram

1997 • 38 citations

The Type IV Phosphodiesterase Inhibitors, Ro 20-1724 and Rolipram, Block the Initiation of Cocaine Self-Administration

1999 • 36 citations

Stimulation of the hypothalamo‐pituitary‐adrenal axis in the rat by three selective type‐4 phosphodiesterase inhibitors: in vitro and in vivo studies

1997 • 35 citations

Regulation of interleukin-13 by type 4 cyclic nucleotide phosphodiesterase (PDE) inhibitors in allergen-specific human T lymphocyte clones

1997 • 35 citations

Molecular Cloning and Expression of a Human Phosphodiesterase 4C

1997 • 30 citations

The in vivo pharmacology of CP-80, 633, a selective inhibitor of phosphodiesterase 4.

1996 • 29 citations

Expression and regulation of mRNA for distinct isoforms of cAMP-specific PDE-4 in mitogen-stimulated and leukemic human lymphocytes

1998 • 29 citations

Theophylline-induced mesenteric periarteritis in F344/N rats

1998 • 28 citations

Role of Cyclic Adenosine Monophosphate in Reducing Superoxide Anion Generation in Guinea Pig Alveolar Macrophages

1998 • 24 citations

Type 4 phosphodiesterase inhibitors and their potential in the treatment of inflammatory disease

1997 • 24 citations

Effect of Pregnancy on PDE4 cAMP-Specific Phosphodiesterase Messenger Ribonucleic Acid Expression in Human Myometrium

1999 • 23 citations

Cyclic Nucleotide Phosphodiesterase 4 Subtypes Are Differentially Expressed by Primary Keratinocytes and Human Epidermoid Cell Lines

1998 • 22 citations

The phosphodiesterase i.v. inhibitor rolipram in vitro reduces the numbers of MBP-reactive IFN-gamma and TNF-alpha mRNA expressing blood mononuclear cells in patients with multiple sclerosis.

1998 • 21 citations

Anti-inflammatory and bronchodilator properties of KF19514, a phosphodiesterase 4 and 1 inhibitor

1997 • 20 citations

Rolipram, an Antidepressant That Increases the Availability of cAMP, Transiently Enhances Wakefulness in Rats

1998 • 20 citations

Phosphodiesterase type 4 inhibitors, but not glucocorticoids, are more potent in suppression of cytokine secretion by mononuclear cells from atopic than nonatopic donors☆☆☆★

1998 • 20 citations

Phosphodiesterases 4 Inhibitors

1998 • 19 citations

Drug Treatment of Asthma in the 1990s

1999 • 15 citations

Novel phosphodiesterase 4 inhibitor T-440 reverses and prevents human bronchial contraction induced by allergen.

1998 • 15 citations

Differential efficacy of lymphocyte- and monocyte-selective pretreatment with a type 4 phosphodiesterase inhibitor on antigen-driven proliferation and cytokine gene expression

1997 • 14 citations

A selective type 4 phosphodiesterase inhibitor, T-440, modulates intracellular cyclic AMP level and interleukin-2 production of Jurkat cells

1998 • 13 citations

SB-207499

1998 • 12 citations

Effects of a Selective PDE4 Inhibitor, D-22888, on Human Airways and Eosinophils in vitro and Late Phase Allergic Pulmonary Eosinophilia in Guinea Pigs

1998 • 11 citations

Effect of T-440, a Novel Type IV Phosphodiesterase Inhibitor, on Allergen-Induced Immediate and Late Asthmatic Reaction and Leukocyte Infiltration into the Airways of Guinea Pigs

1997 • 9 citations

Anti-inflammatory effects of theophylline and selective phosphodiesterase inhibitors

1996 • 7 citations

Prevention of ozone-induced airway hyperresponsiveness and epithelial injury by phosphodiesterase inhibitors in guinea pigs

1997 • 5 citations

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