Reduced DNA synthesis and cell viability in small cell lung carcinoma by treatment with cyclic AMP phosphodiesterase inhibitors

Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures.

1995 • 1,968 citations

Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function

1995 • 1,892 citations

Do all programmed cell deaths occur via apoptosis?

1993 • 545 citations

The pharmacology of intracellular Ca2+-release channels

1994 • 448 citations

Tailoring cAMP-signalling responses through isoform multiplicity

1997 • 437 citations

Different prooxidant levels stimulate growth, trigger apoptosis, or produce necrosis of insulin-secreting RINm5F cells. The role of intracellular polyamines.

1994 • 372 citations

The Shape of Cell Death

1997 • 302 citations

Long-term survival in small-cell lung cancer: posttreatment characteristics in patients surviving 5 to 18+ years--an analysis of 1,714 consecutive patients.

1995 • 267 citations

Expression of a Ryanodine Receptor-Ca ²⁺ Channel that is Regulated by TGF-β

1992 • 247 citations

TGF-beta 1 and cyclic AMP promote apoptosis in resting human B lymphocytes.

1995 • 209 citations

PKA isoforms, neural pathways, and behaviour: making the connection

1997 • 202 citations

Neuronal necrosis and apoptosis: two distinct events induced by exposure to glutamate or oxidative stress.

1997 • 145 citations

cAMP-Mediated Signals as Determinants for Apoptosis in Primary Granulosa Cells

1995 • 145 citations

Calmodulin-regulated adenylyl cyclases and neuromodulation

1997 • 138 citations

Agents That Elevate cAMP Inhibit Human Neutrophil Apoptosis

1995 • 137 citations

Cyclic AMP signalling and cellular proliferation: regulation of CREB and CREM

1997 • 110 citations

PACAP Type I Receptor Activation Promotes Cerebellar Neuron Survival Through the cAMP/PKA Signaling Pathway

1997 • 110 citations

Growth Inhibition and Induction of Apoptosis by Fenretinide in Small-Cell Lung Cancer Cell Lines

1995 • 103 citations

Regulation of E-cadherin-mediated adhesion by muscarinic acetylcholine receptors in small cell lung carcinoma.

1993 • 91 citations

Theophylline synergizes with chlorambucil in inducing apoptosis of B- chronic lymphocytic leukemia cells

1996 • 90 citations

Multiple apoptotic death types triggered through activation of separate pathways by cAMP and inhibitors of protein phosphatases in one (IPC leukemia) cell line

1994 • 84 citations

Cyclic AMP and ethanol interact to control apoptosis and differentiation in hypothalamic beta-endorphin neurons.

1994 • 82 citations

Adenosine A2a receptor activation delays apoptosis in human neutrophils.

1997 • 80 citations

[D-Arg1,D-Trp5,7,9,Leu11]substance P: a novel potent inhibitor of signal transduction and growth in vitro and in vivo in small cell lung cancer cells.

1997 • 78 citations

Cellular signaling in thymocyte apoptosis.

1992 • 75 citations

Fas/APO-1(CD95)-Induced Apoptosis of Primary Hepatocytes Is Inhibited by cAMP

1997 • 63 citations

In vitro toxicity of various classes of test agents using the neutral red assay on a human three-dimensional physiologic skin model

1991 • 63 citations

Involvement of hydrogen peroxide production in erbstatin-induced apoptosis in human small cell lung carcinoma cells.

1996 • 57 citations

Concomitant induction of apoptosis and necrosis in cerebellar granule cells following serum and potassium withdrawal

1997 • 56 citations

8-Chloro-cAMP induces apoptotic cell death in a human mammary carcinoma cell (MCF-7) line

1995 • 49 citations

[D-Arg1, D-Phe5, D-Trp7,9, Leu11] Substance-P Induces Apoptosis in Lung Cancer Cell Lines in Vitro

1994 • 48 citations

Inhibition of neuropeptide-stimulated tyrosine phosphorylation and tyrosine kinase activity stimulates apoptosis in small cell lung cancer cells.

1996 • 45 citations

Multiple pathways are involved in protection of MCF‐7 cells against death due to protein synthesis inhibition

1995 • 39 citations

Activation of muscarinic acetylcholine receptors inhibits cell cycle progression of small cell lung carcinoma.

1991 • 39 citations

Cyclic adenosine monophosphate promotes cell survival and retards apoptosis in a factor-dependent bone marrow-derived cell line.

1993 • 36 citations

The Impact of Chemotherapy on Small Cell Carcinoma of the Bronchus

1986 • 35 citations

Regulation of cadherin-mediated adhesion by the small GTP-binding protein Rho in small cell lung carcinoma cells.

1997 • 35 citations

Cholera toxin triggers apoptosis in human lung cancer cell lines.

1997 • 34 citations

Functional glucocorticoid receptor expression is required for cAMP-mediated apoptosis in a human leukemic T cell line.

1995 • 34 citations

Induction of apoptosis and inhibition of small cell lung cancer growth by the quinoxaline tyrphostins.

1997 • 33 citations

Cholera toxin inhibits signal transduction by several mitogens and the in vitro growth of human small-cell lung cancer.

1990 • 30 citations

Basic science of small cell lung cancer.

1997 • 26 citations

Retreatment of Patients Surviving Cancer-Free 2 or More Years After Initial Treatment of Small Cell Lung Cancer

1996 • 24 citations

Surgical treatment of peripheral small cell lung cancer.

1997 • 21 citations

Surgical Resection in the Management of Small-Cell Carcinoma of the Lung

1993 • 18 citations

Growth inhibition by cholera toxin of human lung carcinoma cell lines: correlation with GM1 ganglioside expression.

1992 • 15 citations

Inhibition of voltage-gated ca2+ channel activity in small cell lung carcinoma by the ca2+/calmodulin-dependent protein kinase inhibitor KN-62 (1-[n,o-bis(5-isoquinolinesulfonyl)-n-methyl-L-tyrosyl]-4-phenylpiperazine)

1995 • 12 citations

Is there a place for surgery in central small cell lung cancer?

1997 • 11 citations

cAMP and ‘death signals’ in a myeloid leukaemia cell: from membrane receptors to nuclear responses: a review

1997 • 9 citations

The impact of chemotherapy on small cell carcinoma of the bronchus

1987 • 9 citations

Alteration of Cell Signalling in Chemical Toxicity

1996 • 8 citations

Cellular signaling in cell death.

1993 • 4 citations

Fetal Development and the Battle of the Sexes

1992 • 2 citations

Deleted Work

1955 • 0 citations