Phosphodiesterase profiles of highly purified human peripheral blood leukocyte populations from normal and atopic individuals: A comparative study☆☆☆★★★

A distinct array of proinflammatory cytokines is expressed in human colon epithelial cells in response to bacterial invasion.

1995 • 1,205 citations

The novel subset of CD14⁺/CD16⁺ blood monocytes exhibits features of tissue macrophages

1993 • 383 citations

Assay of cyclic nucleotide phosphodiesterase and resolution of multiple molecular forms of the enzyme.

1979 • 244 citations

Elevated leukocyte cyclic AMP—phosphodiesterase in atopic disease: a possible mechanism for cyclic AMP—agonist hyporesponsiveness

1982 • 226 citations

Identification of cyclic AMP phosphodiesterases 3, 4 and 7 in human CD4⁺ and CD8⁺ T‐lymphocytes: role in regulating proliferation and the biosynthesis of interleukin‐2

1996 • 218 citations

Type 4 Phosphodiesterase Inhibitors Have Clinical and In Vitro Anti-inflammatory Effects in Atopic Dermatitis

1996 • 217 citations

The short-term activation of a rolipram-sensitive, cAMP-specific phosphodiesterase by thyroid-stimulating hormone in thyroid FRTL-5 cells is mediated by a cAMP-dependent phosphorylation.

1994 • 183 citations

Hormonal Regulation of Cyclic Nucleotide Phosphodiesterases*

1991 • 153 citations

In vitro differentiation of human monocytes to macrophages: change of PDE profile and its relationship to suppression of tumour necrosis factor‐α release by PDE inhibitors

1997 • 143 citations

Expression and regulation of human and rat phosphodiesterase type IV isogenes

1994 • 139 citations

Altered prostaglandin E2 regulation of cytokine production in atopic dermatitis.

1993 • 133 citations

The ratPDE3/IVd phosphodiesterase gene codes for multiple proteins differentially activated by cAMP-dependent protein kinase

1994 • 132 citations

Multiple high-affinity cAMP-phosphodiesterases in human T-lymphocytes

1991 • 130 citations

Activation and selective inhibition of a cyclic AMP-specific phosphodiesterase, PDE-4D3.

1995 • 127 citations

Stimulation of beta adrenoceptors in a human monocyte cell line (U937) up-regulates cyclic AMP-specific phosphodiesterase activity.

1992 • 124 citations

Regulation of distinct cyclic AMP-specific phosphodiesterase (phosphodiesterase type 4) isozymes in human monocytic cells.

1995 • 118 citations

Effects of theophylline and rolipram on leukotriene C₄ (LTC₄) synthesis and chemotaxis of human eosinophils from normal and atopic subjects

1996 • 106 citations

Differential effects of non‐selective and selective phosphodiesterase inhibitors on human eosinophil functions

1995 • 102 citations

Expression of mdrl, mrp, topoisomerase IIα/β, and cyclin A in primary or relapsed states of acute lymphoblastic leukaemias

1995 • 92 citations

Salbutamol Up-regulates PDE4 Activity and Induces a Heterologous Desensitization of U937 Cells to Prostaglandin E2

1995 • 92 citations

Monocyte Phosphodiesterase Abnormalities and Dysregulation of Lymphocyte Function in Atopic Dermatitis

1995 • 89 citations

An improved assay of cyclic 3?,5?-nucleotide phosphodiesterases with QAE-Sephadex columns

1980 • 88 citations

Increased Interleukin-4 Production by Atopic Mononuclear Leukocytes Correlates with Increased Cyclic Adenosine Monophosphate – Phosphodiesterase Activity and Is Reversible by Phosphodiesterase Inhibition

1993 • 85 citations

Cyclic nucleotide phosphodiesterase isoenzyme activities in human alveolar macrophages

1995 • 85 citations

Prolonged beta adrenoceptor stimulation up-regulates cAMP phosphodiesterase activity in human monocytes by increasing mRNA and protein for phosphodiesterases 4A and 4B.

1996 • 85 citations

Modulation of antigen- and mitogen-induced proliferative responses of peripheral blood mononuclear cells by nonselective and isozyme selective cyclic nucleotide phosphodiesterase inhibitors.

1994 • 82 citations

Immunochemical characterization of the distinct monocyte cyclic AMP-phosphodiesterase from patients with atopic dermatitis

1993 • 82 citations

Cyclic nucleotide phosphodiesterases from purified human CD4⁺ and CD8⁺ T lymphocytes

1995 • 79 citations

The cDNA of a human lymphocyte cyclic-AMP phosphodiesterase (PDE IV) reveals a multigene family

1993 • 75 citations

Molecular cloning and functional expression in yeast of a human cAMP‐specific phosphodiesterase subtype (PDE IV‐C)

1995 • 74 citations

Differential inhibitor effects on cyclic adenosine monophosphate-phosphodiesterase isoforms in atopic and normal leukocytes.

1993 • 71 citations

Phosphodiesterase inhibitors suppress proliferation of peripheral blood mononuclear cells and interleukin-4 and -5 secretion by human T-helper type 2 cells

1996 • 60 citations

Blood monocytes of untreated asthmatics exhibit some features of tissue macrophages

1995 • 52 citations

Monocyte Localization of Elevated cAMP Phosphodiesterase Activity in Atopic Dermatitis

1986 • 48 citations

Prostaglandin E2 control of T cell cytokine production is functionally related to the reduced lymphocyte proliferation in atopic dermatitis

1996 • 44 citations

Differential effect of phosphodiesterase 4 inhibitors on the proliferation of human peripheral blood mononuclear cells from normals and subjects with atopic dermatitis

1995 • 39 citations

Phosphodiesterase type IV inhibitors as antiinflammatory agents

1995 • 36 citations

Lymphocyte Response to Phytohemagglutinin in Atopic Dermatitis

1979 • 34 citations

Depressed lymphocyte transformation and the role of prostaglandins in atopic dermatitis

1990 • 25 citations

Mdr1P-glycoprotein expression in natural killer (NK) cells enriched from peripheral or umbilical cord blood

1993 • 23 citations

Involvement of blood coagulation factor XIII in burn healing in the carbon tetrachloride-induced hepatic injury model in rats

1995 • 22 citations

Advances in Clinical Pharmacology

1996 • 17 citations

Interaction of PDE4 Inhibitors with Enzymes and Cell Functions

1996 • 16 citations